Ayn type of recovery prediction for stroke is absolutely useless to survivors. DELIVER 100% RECOVERY PROTOCOLS! Which is what survivors want! WHY THE FUCK AREN'T YOU DOING THAT?

Laziness? Incompetence? Or just don't care? NO leadership? NO strategy? Not my job? Not my Problem?

Predictive value of lymphocyte-associated inflammation index in post-stroke cognitive impairment: a systematic review and meta-analysis

Fengle Mao ^1* XIa He ^2* Xia-lian Huang ^2* Yue-Ming Cheng ¹ Fu-Li Qin ^1* Yan-Qiu Wang ^1*

• ¹ School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China
• ² Sichuan Bayi Rehabilitation Centre (Sichuan Rehabilitation Hospital), Chengdu, China, Chengdu, China

The final, formatted version of the article will be published soon.

Background: 

The predictive role of the lymphocyte-associated inflammation index in post-stroke cognitive impairment (PSCI) remains controversial. Therefore, we performed an updated meta-analysis to update the evidence. Methods: This meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Six databases were systematically searched from their inception to May 5, 2024. Two investigators independently conducted literature screening and data extraction for the included studies. Two investigators independently assessed the quality of the included studies using the Newcastle-Ottawa Scale (NOS). Combined effect sizes were calculated using weighted mean difference (WMD) or standardized mean difference (SMD) with 95% confidence intervals (CIs). Heterogeneity was tested using the chi-square (χ2) test (Cochran's Q) and index of inconsistency (I2), Publication bias was assessed using funnel plots and Egger's regression test. Results: This systematic review included a total of 16 studies, encompassing 3406 patients. Meta-analysis revealed that neutrophil-to-lymphocyte ratio (NLR) levels were significantly higher in the PSCI group compared to the non-PSCI group (WMD: 1.12; 95% CI: 0.85, 1.40; p<0.00001). Similarly, the platelet-to-lymphocyte ratio (PLR) levels were significantly higher in the PSCI group compared to the non-PSCI group (WMD: 16.80; 95% CI: 4.30, 29.29; p=0.008). However, there was no statistically significant difference between the two groups concerning hemoglobin, albumin, lymphocyte, and platelet (HALP) scores (WMD: -12.78; 95% CI: -25.95, 0.38; p=0.06) and lymphocyte count (WMD: -0.13; 95% CI: -0.34, 0.07; p=0.20). 

 Conclusion: 

Increased levels of PLR and NLR are strongly associated with the PSCI, which may serve as an effective tool for predicting PSCI. However, there is insufficient evidence to support a direct relationship between HALP scores, lymphocyte count, and PSCI.

Keywords: post-stroke cognitive impairment1, lymphocyte2, inflammation index3, Systematic review4, Meta-analysis5

Received: 23 Jul 2024; Accepted: 23 Dec 2024.

Copyright: © 2024 Mao, He, Huang, Cheng, Qin and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.