Deans' stroke musings: Japan Team Finds Substance to Help Keep Post-Stroke Recovery

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, May 15, 2026

Japan Team Finds Substance to Help Keep Post-Stroke Recovery

Your fuckingly incompetent? doctor DID NOTHING WITH ALL THIS EARLIER RESEARCH! And you still see them?

IGF-1 (20 posts to March 2014)

Japan Team Finds Substance to Help Keep Post-Stroke Recovery

Tokyo, May 14 (Jiji Press)--A team including Takashi Shichita, a professor at the Institute of Science Tokyo's Medical Research Laboratory, has developed a drug candidate to suppress a type of protein that causes the rehabilitation-induced partial recovery of motor functions lost from a stroke to end after only about two months.

People who lost the abilities to move their hands or feet, or to speak due to the deaths of some nerve cells in their brains from the cerebral infarction can regain the functions to a certain extent through rehabilitation. The recovery normally lasts for about two months.

The recovery is possible because surviving nerve cells repair the neuron networks, with microglia, or cells in charge of brain immunity, helping the restoration process by secreting a protein called insulin-like growth factor 1, or IGF1.

In a genetic manipulation experiment using mice, Shichita and other members of the team discovered that microglia stopped secreting IGF1 after a while following a stroke due to the function of another protein, ZFP384. The same mechanism was confirmed in the brains of dead stroke patients.

The team developed the drug candidate to block the production of ZFP384. After injecting the drug into mice, the team found that microglia continued to secrete IGF1 and helped maintain the recovery of brain functions.