Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 33,134 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain!trillions and trillions of neuronsthatDIEeach day because there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Tuesday, May 19, 2026
Untargeted Plasma Metabolomics Reveals Metabolic Signatures of High- and Low-Polyphenol Cocoa Intake Potentially Linked to Adult Hippocampal Neurogenesis
Are your doctor and hospital competent? enough to ensure human
testing occurs with specific cocoa% figures? If you don't get it started now your grandchildren won't
get the benefits on their stroke recovery.
Do you prefer your doctor, hospital and board of director's incompetence NOT KNOWING? OR NOT DOING? Your choice; let them be incompetent or demand action! You do know incompetent doctors and hospitals can be fired!
High-phenolic cocoa consumption significantly enhances adult hippocampal neurogenesis in mice.
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Untargeted metabolomics identified 52 plasma metabolites linked to cocoa intake.
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Itaconic acid was identified as a key marker of high-phenolic cocoa consumption.
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High-phenolic cocoa intake selectively modulates biotin, caffeine, and butanoate pathways.
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Phenylalanine and 2-octenedioic acid reveal sex-specific metabolic responses.
ABSTRACT
Cocoa consumption is widely recognized for its health benefits, mainly due to the antioxidant and anti-inflammatory properties of its polyphenols, particularly flavanols. Emerging evidence suggests that cocoa may support brain function by reducing neuroinflammation and promoting adult hippocampal neurogenesis (AHN). However, the systemic metabolic pathways underlying these outcomes remain unclear. This study employed untargeted metabolomics to investigate systemic responses to natural cocoa intake in a cohort of adult C57BL/6JRj mice of both sexes. Animals received for 50 days either a control diet (CTR) or diets enriched with 10% of high-phenolic (HPC) or low-phenolic cocoa (LPC). The experimental design included a battery of behavioral tests and immunohistochemical assessment of AHN. Plasma metabolomic profiling was performed using HPLC-ESI-QTOF-MS/MS, followed by multivariate and univariate statistical analyses, metabolite annotation, and pathway enrichment. While the HPC diet significantly enhanced neuronal proliferation, differentiation and survival, supervised OPLS-DA modeling identified 52 discriminant metabolites differentiating cocoa-fed from control mice (HPC vs. CTR: Q2 = 0.826; LPC vs. CTR: Q2 = 0.848; p < 0.001). Among annotated metabolites, only itaconic acid significantly increased exclusively in the HPC group (p = 0.022). Pathway enrichment revealed alterations in biotin, caffeine, and butanoate metabolism solely in the HPC group, suggesting that high-phenolic cocoa intake selectively modulates biochemical pathways with potential relevance to AHN. Sex-dependent interactions were observed in phenylalanine and 2-octenedioic acid. These findings together underscore the utility of metabolomics for elucidating the molecular impact of dietary interventions and support the role of natural cocoa as a functional food with neuroprotective potential.
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