http://www.jultrasoundmed.org/content/32/7/1117.abstract
Abstract
New therapeutic strategies under
development aim to improve recanalization rates and clinical outcomes
after ischemic stroke.
One such approach is ultrasound (US)-enhanced
thrombolysis, or sonothrombolysis, which can improve thrombolytic drug
actions
and even intrinsic fibrinolysis. Although the
mechanisms are not fully understood, it is postulated that thrombolysis
enhancement
is related to nonthermal mechanical effects of US.
Recent results indicate that US with or without microbubbles may be
effective
in clot lysis of ischemic stroke even without
additional thrombolytic drugs. Sonothrombolysis is a promising tool for
treating
acute ischemic stroke, but its efficacy, safety,
and technical details have not been elucidated and proved yet in stroke
treatment.
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