Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, September 30, 2021

Patients who develop cognitive impairment had changes in the brain before their stroke

This changes nothing; it is still your doctor's responsibility to bring your cognition back to normal.

My doctor told me I had a bunch of white matter hyperintensities but never showed me them on any scan, so I don't know the size, location or any intervention needed, because my doctor knew nothing and did nothing. I have zero cognitive impairment.

Patients who develop cognitive impairment had changes in the brain before their stroke

Figure 1. Examples of stroke lesion segmentation. Examples of voxel-based segmentation of stroke lesions in MNI space, as shown in the coronal, sagittal, and horizontal plane. Color map depicts a larger number of voxels and thus also a larger stroke increasing from red to yellow. Credit: DOI: 10.3389/fnagi.2021.705889

Stroke is caused by disturbances in the blood circulation of the brain due to blood clots or cerebral hemorrhage. This causes damage to parts of the brain, and the patient experiences a sudden loss of particular body functions. Individuals affected by stroke need urgent, life-saving treatment followed by rehabilitation. In Norway, stroke affects approximately 12,000 people each year.

"It appears that about 50 percent of get some form of cognitive impairment after the stroke," says Till Schellhorn, who has written his doctoral thesis at the Institute of Clinical Medicine based on the Nor-COAST study.

Cognitive impairment means that an individual's ability to think and to perform intellectual and mental processes has been reduced.

Identifying at-risk patients using MRI images

The researchers examined the brains of patients who developed cognitive impairment after stroke using MRI images. MRI stands for magnetic resonance imaging, and is a method used to take pictures of the body's internal organs.

"Using MRI images of the , we can identify risk patients for the development of cognitive impairment after stroke with good certainty," says the researcher.

The MRI images showed that patients who develop cognitive impairment after stroke already had brain changes prior to the stroke that may be associated with the development of cognitive impairment.

"It was mainly the case for patients with small vessel disease, who have a reduced circulation in the small blood vessels in the brain. This can lead to many small cerebral infarctions, and was associated with the development of cognitive impairment after stroke," Schellhorn explains.

Furthermore, the results showed that the size of the stroke was associated with increased risk of developing cognitive impairment. The larger the stroke, the higher the risk of developing cognitive impairment afterwards.

There was also an association between loss of substance in the temporal lobe, which is a part of the brain associated with memory, and the development of cognitive impairment.

"But this association was less pronounced than we had expected," he points out.

Has put cognitive impairment after stroke on the agenda—The Nor-COAST study has put cognitive impairment after stroke on the agenda. In the past, the focus has mostly been on paralysis and other physical ailments, and therefore cognitive impairment has received little attention, Schellhorn explains, and adds:

"But cognitive function means a great deal for the quality of life, both of the patient and their families."

The researchers have set themselves the goals of contributing to more knowledge about the causes of cognitive impairment and developing methods for identifying at-.

"You have to know whom, and why the individual patient develops cognitive impairment in order to be able to start a treatment," he points out.

Aim for better preventive measures and treatment: "We hope that our research can lead to better treatment of cognitive impairment after stroke in the future. We hope that we can prevent and alleviate cognitive impairment," Schellhorn says.

The researchers are now testing potential preventive measures and novel forms of treatment.

"This could entail preventive treatment among stroke patients with a high risk of developing cognitive impairment, or treatment of the causes, such as cardiovascular disease," the researcher says.

Schellhorn further states that increased physical or social activity as part of rehabilitation after a stroke might slow down the development of cognitive impairment.

A model for clinical use

Eight hundred and fifteen stroke patients were included in the study. The researchers took MRI images of the brain of 410 of them.

The researchers examined these images thoroughly. On the MRI images, which were taken after the stroke, they could see which patients had changes in the brain that had been present already prior to the stroke. To do this, they used different types of MRI images, some that show that brain changes are acute and some that show brain changes of older date.

"It is a combination of specific MRI technique and interpretation that helps us say something about the age of the brain changes," Schellhorn points out.

The researchers believe that some of these changes in the brain were related to the development of cognitive impairment after stroke.

"We investigated the association between the image findings and cognitive impairment. We created a model for predicting the risk of based on the findings on the images," Schellhorn explains.

So far, the model has only be

en tested within the scope of the Nor-COAST study, but the researchers already have plans to test it on more patients. However, there are also a number of practical challenges that must be solved before the model can be used in a clinical context, i.e. for use in connection with the treatment of patients.

"Before using new computer programs at the hospital, the models must go through a routine security check. Such things typically take some time. But I hope that we can use our models in the clinic at the hospital over the next two to three years."


Explore further

Cognitive impairment reported after COVID-19 infection

More information: Eva Birgitte Aamodt et al, Predicting the Emergence of Major Neurocognitive Disorder Within Three Months After a Stroke, Frontiers in Aging Neuroscience (2021). DOI: 10.3389/fnagi.2021.705889
Provided by University of Oslo
 

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