Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, October 30, 2024

Cardiovascular health in middle age strongly associated with brain health in later years

 3 years post stroke at a physical I had a resting heart rate of 54 at age 53, level of an athlete. My doctor asked what exercises I was doing; 'I've done no exercises for the past 3 years'.  

Still had a stroke because my dad's doctor didn't tell him to have his children tested for carotid plaque when he was found to have 80% blockage in his 80's. I'm not going to get either dementia or late life depression, there is too much fun yet to be had.

I'm definitely an optimist, will live to 100 because of these two quotes assuming I'm not too reckless; 

Part of my Hunter S. Thompson journey;

“Life should not be a journey to the grave with the intention of arriving safely in a pretty and well preserved body, but rather to skid in broadside in a cloud of smoke, thoroughly used up, totally worn out, and loudly proclaiming "Wow! What a Ride!”

"Your body is not a temple: It's an amusement park. Enjoy the ride." Anthony Bourdain

The latest here:

Cardiovascular health in middle age strongly associated with brain health in later years

Key takeaways:

  • Lifestyle habits such as diet and exercise were linked to a higher risk for stroke or dementia later in life.
  • More research is needed, including how factors such as race and ethnicity influence the association.

Cardiovascular health of middle-aged adults was significantly associated with the risk of poor brain health later in life, according to a study published in Neurology.

“Brain health is paramount for the optimal well-being of every person, enabling us to function at our highest level and constantly adapt in the world,” Santiago Clocchiatti-Tuozzo, MD, MHS, study author and postdoctoral fellow in geriatric clinical epidemiology and aging-related research in the department of neurology at Yale University, said in a release related to the study.

Heart_Brain_Two_2019_Adobe
The latest research into brain and heart health found that ardiovascular health of middle-aged adults was significantly associated with the risk of poor brain health later in life. Image: Adobe Stock

The American Heart Association’s Life’s Essential 8 (LE8) is a compilation of factors that determine cardiovascular health, although its cumulative effect on metrics related to brain health is unknown. The score encompasses eight modifiable cardiovascular risk factors: blood pressure, glucose, cholesterol, BMI, smoking, physical activity, diet, sleep duration. The factors are organized into 3 subcategories: optimal, intermediate and poor.

Clocchiatti-Tuozzo and colleagues investigated the supposition that worse LE8 profiles in middle-aged adults are associated with higher overall risk of the most relevant clinical factors that contribute to poor brain health.

The researchers engaged in a two-stage prospective study that culled data from the U.K. Biobank (UKB) and All of Us (AoU), the former from the United Kingdom that enrolled more than 500,000 individuals between 2006 and 2010 and the latter an ongoing U.S. cohort study being conducted by the NIH since 2018 with 400,000 people currently enrolled. The discovery stage included 316,127 UKB participants (mean age, 56 years; 52% women), while the replication stage included 68,407 AoU participants (mean age, 56 years; 60% women).

LE8 score was calculated for each individual component, then again for overall score for each participant as an unweighted average of the eight component scores; researchers subsequently divided the overall LE8 scores into three subcategories based on total score (less than 20 meaning poor cardiovascular health; 20 to 80 as intermediate and more than 80 representing optimal cardiovascular health).

The study’s primary outcome was a composite of stroke, dementia or late-life depression, with additional covariate analysis including demographic information collected at each study’s baseline interviews.

According to results, over a mean follow-up time of 4.9 years in the discovery stage, the unadjusted risks for composite outcomes were 0.7% (95% CI 0.61–0.74) for optimal, 1.2% (95% CI 1.11–1.22) for intermediate and 1.8% (95% CI 1.70–1.91) for poor cardiovascular health, respectively.

Data further showed that, over a follow-up of 2.9 years for the replication stage, unadjusted risk of composite outcomes was 2.8% (95% CI 2.49–3.05) for optimal, 6% (95% CI 5.76–6.22) for intermediate and 9.7% (95% CI 9.24–10.24) for poor cardiovascular health.

The association remained in comparative analysis of intermediate vs. optimal cardiovascular health (HR = 1.35; 95% CI, 1.21–1.51) and poor vs. optimal cardiovascular health (HR =1.94; 95% CI, 1.72–2.18).

“Our findings highlight the potential brain health benefits of using these eight cardiovascular and brain health factors to guide healthy lifestyle choices,” Clocchiatti-Tuozzo said in the release. “More research is needed to understand this link between lifestyle habits and brain health, as well as how social factors like race and ethnicity can influence this connection.”

Reference:

Live well, think well: Research shows healthy habits tied to brain health. https://www.aan.com/PressRoom/Home/PressRelease/5208. Published Oct. 24, 2024. Accessed Oct. 28, 2024.

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