Deans' stroke musings: Inflammatory Oriented Nanospheres-Reconstructed Extracellular Matrix in Ischemic Stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, June 11, 2025

Inflammatory Oriented Nanospheres-Reconstructed Extracellular Matrix in Ischemic Stroke

Ask your competent? doctor if this was actually tested in humans and the recovery results.

Inflammatory Oriented Nanospheres-Reconstructed Extracellular Matrix in Ischemic Stroke

Zehua Gao
Xuanlin Wang
Wenchao Zhang
Jing Wang*
Changsheng Liu*

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Abstract

The prevention and treatment of postoperative complications of ischemic stroke remain significant challenges. These complications primarily result from the destruction of the extracellular matrix (ECM) and neurovascular units. In the subacute phase, chronic inflammation further aggravates brain tissue damage. To address these challenges, we propose a strategy to prevent secondary brain injury and complications by modulating immunity and ECM remodeling. To specifically target the inflammatory microenvironment within the ischemic core, we designed sulfonated chitosan liposome microspheres embedded with neutrophil membranes (MLS). These MLS inhibitors inhibited glial scar formation and promoted collagen IV expression. By effectively regulating ECM reconstruction, we aimed to create a favorable microenvironment for the remodeling of neurovascular units and neurofilaments, thereby reducing the number of secondary injuries. Additionally, the high expression of α5β1 in brain endothelial cells (bEnd.3) facilitated the formation of a mature vascular network. This finding represents a therapy for preventing and treating postoperative complications of ischemic stroke. Through modulation of immunity and ECM remodeling, this approach provides a targeted and effective solution to minimize secondary injuries and improve overall rehabilitation outcomes.