Hyperbaric oxygen therapy combined with computerized cognitive training improves global cognition and functional independence post-stroke: a randomized controlled trial

Why do HBOT when there are vastly simpler, cheaper and less risky ways to increase oxygen uptake?

 I can't see any use for HBOT unless it's delivered in the first week and there are vastly easier options for delivering oxygen than that.

Google this for risks: hyperbaric oxygen therapy deaths. 

Here are 43 posts on HBOT for your edification

• Metformin (19 posts to July 2012)

Well, since this has been around for years why the hell doesn't someone actually do human testing and create protocols on stroke recovery?

Earlier research has this line:The drug, which is cheaply available for just $0.16 a day, works by boosting the number of oxygen molecules released into a cell, which in turn seems to benefit the robustness and longevity of the body’s basic building blocks. (This would seem to be much easier and faster than HBOT. I'm requesting this at my next stroke, my doctor won't know what hit her when I tell her how to treat me.)

If your doctor doesn't know about this s/he IS COMPLETELY FUCKING INCOMPETENT? And not creating protocols is even worse, allowing millions to billions of neurons to die because of lack of oxygen during the neuronal cascade of death!

 What other protocols is your doctor using to significantly improve oxygen delivery immediately post stroke? The first hours and days? NOTHING? Then you DON'T have a functioning stroke doctor, do you?

Maybe these, why isn't your incompetent doctor already delivering these to you?

cerebral blood flow (29 posts to July 2016)

Cerebral blood flow autoregulation (1 post to July 2021)

Cerebral Blood Flow Velocity (1 post to Febraury 2020)

cortical oxygenation (1 post to November 2020)

oxygen delivery (20 posts to January 2020)

oxygen uptake (5 posts to August 2013)

• Super Saturated Oxygen Therapy (1 post to May 2021)

Normobaric oxygen (10 posts to January 2020)

brain blood flow (3 posts to April 2019)

 Oh, your incompetent doctor doesn't have any and doesn't fucking care about learning better ways to get you recovered! Well, fire them! PREDICTING DAMAGE DOES NOTHING!

The latest here:

Hyperbaric oxygen therapy combined with computerized cognitive training improves global cognition and functional independence post-stroke: a randomized controlled trial

• Jing Liu,
• Tao Han,
• Cuihua Yan,
• Qingping Ma,
• Lingling Yuan,
• Shulong Ge,
• Xiaolei Xu &
• Xuewu Liu 

• 1 Access

• Explore all metrics

We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

Abstract

Background

Post-stroke cognitive impairment (PSCI) is prevalent following stroke. Both hyperbaric oxygen therapy (HBOT) and cognitive training have demonstrated efficacy in the treatment of PSCI; however, it remains unclear whether combining HBOT with cognitive training has a synergistic effect on global cognition and functional independence in PSCI.

Objective

We aimed to investigate the effects of HBOT combined with computerized cognitive training (CCT) on global cognition and functional independence in patients with PSCI, and to explore associated neural correlates.

Methods

In this single-center, randomized controlled clinical trial, 116 patients with PSCI (39 ischemic, 77 hemorrhagic) were randomly assigned to four groups who received HBOT+standard treatment, CCT+standard treatment, combined HBOT + CCT+standard treatment, or standard treatment alone. All groups received 20 treatment sessions over 4 weeks (five sessions/week). Global cognition was assessed before and after treatment using the Mini-Mental State Examination (MMSE). Functional independence in basic activities of daily living (ADLs) was assessed using the Barthel Index (BI). Resting-state functional connectivity (FC) was assessed using functional near-infrared spectroscopy.

Results

Patients in the HBOT + CCT group showed significantly greater improvements in MMSE total scores, several MMSE subscores, including orientation, registration, attention, recall, and visuospatial, and BI scores, than the other groups (all ts(112) ≥ 2.74, all Bonferroni-corrected ps ≤ 0.043). Resting-state FC between the left dorsolateral prefrontal cortex and left pars triangularis of Broca’s area was significantly higher in the HBOT + CCT group than in the control group (t(111) = 2.93; Bonferroni-corrected p = 0.025). The change in FC was also significantly correlated with MMSE improvement (r(113) = 0.552, p < 0.001).

Conclusion

Combined HBOT and CCT may represent a beneficial intervention for patients with PSCI and could be associated with changes in global cognition, functional independence in basic ADLs, and prefrontal functional connectivity.

Trial registration The study has been listed in the Chinese Clinical Trial Registry (ChiCTR2400080685).