Deans' stroke musings: Clinical study of repetitive transcranial magnetic stimulation in the rehabilitation of post-stroke depression: A Quantitative Insomnia Sleep Inventory monitoring evaluation

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, March 1, 2026

Clinical study of repetitive transcranial magnetic stimulation in the rehabilitation of post-stroke depression: A Quantitative Insomnia Sleep Inventory monitoring evaluation

You're that stupid that preventing depression by having 100% recovery protocols is not even in your thought process? My god, you're all fired for incompetency!

Clinical study of repetitive transcranial magnetic stimulation in the rehabilitation of post-stroke depression: A Quantitative Insomnia Sleep Inventory monitoring evaluation

Ai-Ming Gu,

Chao Liu,

Jian-Hong Chen,

Ru-Ya Guo,

Chao Liang,

Xing-Shi Chen

Ai-Ming Gu, Department of Neurology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing 314000, Zhejiang Province,

China Chao Liu, Department of Psychiatry, The First Hospital of Jiaxing, Jiaxing 314000, Zhejiang Province, China

Jian-Hong Chen, Department of Medical, Jinhua City Durg Rehabilitation Isolation Center, Jinhua 321000, Zhejiang Province, China

Ru-Ya Guo, Department of Endocrinology, The First Hospital of Jiaxing, Jiaxing 314000, Zhejiang Province, China

Chao Liang, Department of General Practice, The First Hospital of Jiaxing, Jiaxing 314000, Zhejiang Province, China

Xing-Shi Chen, Department of Electrophysiology, Shanghai Mental Health Center, Shanghai 200030, China ORCID number: Ai-Ming Gu (0009-0006-5409-9052); Chao Liu (0009-0002-3804-7245); Jian-Hong Chen (0009-0004-2333-0632); Ru-Ya Guo (0009-0002-8282-5315); Chao Liang (0009-0006-0072-6153); Xing-Shi Chen (0009-0005-0237-6196). Co-first authors: Ai-Ming Gu and Chao Liu. Co-corresponding authors: Jian-Hong Chen and Ru-Ya Guo. Author contributions: Gu AM and Chen JH designed the study; Gu AM, Guo RY, and Chen XS conducted the research; Chen JH and Chen XS provided experimental instruments; Liu C, Chen JH, and Liang C analyzed the data and drafted the manuscript; Gu AM and Liu C contributed equally to this manuscript and are co-first authors; Chen JH and Guo RY contributed equally to this manuscript and are co-corresponding authors. All authors have read and approved the final manuscript.

Supported by National Natural Science Foundation of China, No. 81471357; and the Project of Jinhua Municipal Bureau of Science and Technology, No. 2024-07 and No. 2024-08. Institutional review board statement: This study was reviewed and approved by the Medical Ethics Committee of Shanghai Mental Health Center (Approval No. 2019009). Informed consent statement: All participants in the study signed the informed consent form before commencement of the study. Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items. Data sharing statement: No additional data are available. Corresponding author: Jian-Hong Chen, Department of Medical, Jinhua City Durg Rehabilitation Isolation Center, No. 1 Fangjingtou Community, Fangjingtou Village, Wucheng District, Jinhua 321000, Zhejiang Province, China. 18713190@qq.com Received: November 7, 2025 Revised: December 8, 2025 Accepted: February 5, 2026 Published online: March 19, 2026 Processing time: 111 Days and 23 Hours

Abstract

BACKGROUND Jiaxing Hospital of Traditional Chinese Medicine introduced transcranial magnetic stimulation (TMS) technology in 2019. In practical application, it was found that different types of equipment and technical parameters could lead to differences in therapeutic effects. Therefore, our hospital selected a Danish-made TMS device, which ranked second in the Chinese market, and conducted tests on patients with post-stroke depression (PSD) from March 2019 to September 2023. Before the test, a plan was formulated based on the quality status before and after the inspection. Two evaluators independently controlled the quality of the plan. The repetitive TMS (rTMS) and Quantitative Insomnia Sleep Inventory (QUISI) data were separately stored and verified independently by the two evaluators. AIM To investigate the effect of rTMS and QUISI on the sleep and rehabilitation of patients with PSD.

METHODS

From March 2019 to December 2023, subjects who were admitted to the Department of Rehabilitation of the Jiaxing Hospital of Traditional Chinese Medicine, Shanghai Mental Health Center, and National Medical Centre for Psychiatric Disorders were enrolled. A total of 108 patients with PSD were enrolled: 54 patients in the observation group and 54 in the control group. Sixty-eight normal volunteers were also included. Both the observation group and the control group received venlafaxine 150 mg/day sustained-release therapy. The observation group was given venlafaxine combined with rTMS. The control group was treated with venlafaxine combined with rTMS pseudo stimulation. The two groups underwent 42 treatment sessions over 14 weeks. The Hamilton Depression Rating Scale-17 scores were compared between the two groups before and after treatment, and the changes in QUISI were compared with healthy volunteers.

RESULTS

The Hamilton Depression Rating Scale-17 scores in the two groups were significantly reduced after treatment, and the improvement was more significant in the observation group (P < 0.05). Before treatment, the sleep latency in the two groups of patients by QUISI was delayed compared to normal volunteers, and the sleep efficiency and maintenance rate were lower than those in normal volunteers, with statistical significance (P < 0.05-0.01). After 14 weeks of treatment, the sleep latency period in the observation group QUISI shifted forward, indicating an increase in sleep efficiency and maintenance rate. The differences between the observation group and the control group were statistically significant (P < 0.01). After a 3-month rehabilitation evaluation, the total effective rate of patients in the observation group was significantly higher than that in the control group (P < 0.05).

CONCLUSION

rTMS treatment has a positive effect on PSD in clinical practice. QUISI monitoring can be used for rehabilitation assessment.

Gu AM, Liu C, Chen JH, Guo RY, Liang C, Chen XS. Clinical study of repetitive transcranial magnetic stimulation in the rehabilitation of post-stroke depression: A Quantitative Insomnia Sleep Inventory monitoring evaluation. World J Psychiatry 2026; 16(3): 116094 [DOI: 10.5498/wjp.v16.i3.116094]