Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, March 18, 2026

Safety and neuromodulation effect of transcranial focused ultrasound for motor recovery in patients with subacute stroke

 Didn't your competent? doctor and hospital figure a protocol on ultrasound years ago? NO? So, they were completely fucking incompetent!

The latest here:

Safety and neuromodulation effect of transcranial focused ultrasound for motor recovery in patients with subacute stroke

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Journal of NeuroEngineering and Rehabilitation Aims and scope Submit manuscript
Safety and neuromodulation effect of transcranial focused ultrasound for motor recovery in patients with subacute stroke
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    We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

    Abstract

    Introduction

    Transcranial focused ultrasound (tFUS), a non-invasive brain neuromodulation, can target deeper and more precise brain regions compared to transcranial magnetic stimulation. However, its safety, neuromodulation and therapeutic effects in subacute stroke patients remain unclear. Therefore, the aim of this project is to demonstrate the safety and preliminary efficacy of tFUS for upper limb motor recovery in subacute stroke patients.

    Methods

    In this phase I single-arm study, we recruited 10 patients with subacute (≤ 3 months) unilateral stroke. tFUS was applied to the contralesional M1 by neuronavigation once daily for five sessions, using ISPTA 2.8 W/cm² in free field (estimated in situ < 0.3 W/cm²), MI 0.75, PRF 100 Hz, and duty cycle 30%, with 10-minute exposure per session. The primary outcome was safety over 12 weeks. Secondary outcomes included cortical excitability (evaluated by transcranial magnetic stimulation and functional near-infrared spectroscopy) and functional measures assessed pre-treatment and at 1 day, 1 week, 4 weeks, and 12 weeks.)

    Results

    Ten patients completed the trial, and the safety analysis revealed no severe adverse events (AEs), new imaging abnormalities, or neuropsychological decline; only minor transient AEs occurred in 5 of 10 patients. tFUS showed preliminary therapeutic efficacy, with improvements in hemiplegic upper limb motor recovery and functional performance. Greater FMA improvement was observed in the tFUS group compared with age-, sex-, and baseline FMA-matched patients who received rTMS. Exploratory analyses of cortical excitability measures showed bilateral trends toward facilitation; however, these changes did not reach statistical significance.

    Conclusion

    tFUS was safe and well tolerated in subacute stroke patients, with only minor transient AEs and no evidence of structural or neuropsychological harm. tFUS demonstrated potential to enhance(Survivors want 100%  recovery! What the fuck are you doing to get there? NOTHING? Like good incompetent 'professionals'!) upper limb motor recovery and functional outcomes. Although exploratory analyses suggested trends toward cortical excitability changes, these findings were not statistically significant and require confirmation in larger controlled trials.

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