We've known of this migraine to stroke link for years. The research needed is; 'What treatment of migraines will prevent stroke?' Why hasn't your incompetent? doctor DONE ANYTHING in the past decade to solve this?
Laziness? Incompetence? Or just don't care? NO leadership? NO strategy? Not my job? Not my Problem!
- Migraine with aura
(13 posts to March 2016)
DAMN IT ALL, SOLVE THE PROPER QUESTION!
Migraine with aura linked to greater risk for ischemic stroke in older adults
Key takeaways:
- Men aged younger than 72 years with migraine also saw an increased risk for this outcome.
- Targeted stroke screening may be recommended for this group if the findings are confirmed, researchers said.
Migraine with aura was associated with an increased risk for incident ischemic stroke in middle-aged adults, with no difference among Black and white patients, according to a study published in Neurology Open Access.
Lead study author Adam S. Sprouse Blum, MD, PhD, clinical instructor at the Larner College of Medicine at the University of Vermont, and colleagues further found that any migraine with or without aura was linked to a greater risk for ischemic stroke in men aged younger than 72 years, which was not found in women or older men. The study authors called this finding “contrary to expectations.”
Risks for ischemic stroke increased by 73% for adults with migraine with aura. Image: Adobe Stock
“Previous research has shown that migraine with aura is linked to an increased risk of stroke in younger people but less is known about people 45 years old and older,” Sprouse Blum said in a press release related to the study. “Our study found that similar to younger people, migraine with aura was associated with an increased risk of ischemic stroke in middle-aged and older adults.”
Sprouse Blum and colleagues culled data from the REasons for Geographic and Racial Differences in Stroke cohort to include 11,381 adults aged at least 45 years (mean age, 72.1 years; 55.2% women; 34.8% Black) in their study. At baseline, participants had not yet had a stroke and were asked about migraine incidence.
During a mean follow-up of 6.4 years, 44 of the 1,130 participants (3.9%) who experienced migraine also experienced ischemic stroke; of the 10,251 participants without migraine, 351 (3.4%) experienced the same. Further, of the 491 adults who reported migraine with aura, 23 (4.7%) reported ischemic stroke. Fewer individuals with migraine without aura (21 of 639; 3.3%) reported the same.
The authors reported the incidence of stroke, calculated per 1,000 person-years, to be 6 in those with migraine — including 7.2 for migraine with aura and 5.1 for migraine without aura — and 5.4 in those without migraine.
The overall risk for ischemic stroke in adults with migraine was not significant in fully adjusted models (HR = 1.35; 95% CI, 0.98-1.87), Sprouse Blum and colleagues wrote. While no association for ischemic stroke was found for those with migraine without aura, the study showed a 73% increased risk among adults who experienced migraine with aura (HR = 1.73; 95% CI, 1.12-2.65).
After stratifying by sex and age, the researchers discovered men aged younger than 72 years with migraine had a 3.5 times increased risk for ischemic stroke (HR = 3.67; 95% CI, 1.96-6.88), regardless of whether they had aura. This finding was not seen in women or in men aged 72 years and older.
The study did not uncover any migraine-by-race interaction.
“Our result that middle-aged and older male participants under age 72 had a much higher risk of stroke was unexpected since previous research in young people has shown that stroke disproportionately affects female individuals,” Sprouse Blum said in the press release.
Future studies are needed to further understand and confirm these findings, he added.
“Should the findings be confirmed, it may be necessary to provide targeted stroke prevention counseling for individuals in this age group,” Sprouse Blum said.
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