Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation June 2004
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Cardioprotective Effects of Pomegranate (Punica granatum) Juice in Patients with Ischemic Heart Disease
Abstract
Ischemic
heart disease is the leading cause of mortality worldwide. The purpose
of this study was to evaluate the cardioprotective effects of
pomegranate juice in patients with ischemic heart disease. One hundred
patients, diagnosed with unstable angina or myocardial infarction, were
randomly assigned to the test and the control groups (n = 50, each).
During 5 days of hospitalization, in addition to the conventional
medical therapies, the test groups received 220 mL pomegranate juice,
daily. During the hospitalization period, the blood pressure, heart
rate, as well as the intensity, occurrence, and duration of the angina
were evaluated on a regular basis. At the end of the hospitalization
period, the serum levels of malondialdehyde, interleukin-6, and tumor
necrosis factor alpha were measured in all patients. The levels of serum
troponin and high-sensitive C-reactive protein levels were also assayed
in patients diagnosed with myocardial infarction. Pomegranate juice
caused significant reductions in the intensity, occurrence, and duration
of angina pectoris in patients with unstable angina. Consistently, the
test patients had significantly lower levels of serum troponin and
malondialdehyde. Other studied parameters did not change significantly.
The results of this study suggest protective effects of pomegranate
juice against myocardial ischemia and reperfusion injury. Copyright ©
2017 John Wiley & Sons, Ltd.
Copyright © 2017 John Wiley & Sons, Ltd.
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