Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 33,532 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke. DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain!trillions and trillions of neuronsthatDIEeach day because there areNOeffective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
Saturday, July 11, 2026
Blood–brain barrier permeating dendrimers for alleviation of cerebral ischemia–reperfusion injury
We've known of blood brain barrier problems post stroke a long time ago! Where ARE THE EXACT PROTOCOLS TO PREVENT THAT?
Why is no one solving the problems identified? I know we have fucking failures of stroke associations doing nothing but there must be some leadership out there.
Controlled synthesis yields monodisperse dendrimers with tailored MW and size.
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RONS-triggered deshielding and oxidation enable targeted brain delivery.
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PEG deshielding facilitates BBB penetration into cerebral I/R injury lesions.
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G4-PB-PEG dendrimer reduces infarct volume and improves neurological outcomes.
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Biodegradable components of G4-PB-PEG dendrimer ensure high biocompatibility.
Abstract
Ischemia–reperfusion injury (IRI) is a major contributor to incomplete neurological recovery after ischemic stroke, particularly after reperfusion therapies such as thrombolysis or mechanical thrombectomy. Reperfusion can trigger excessive generation of reactive oxygen and nitrogen species (RONS) and amplify inflammatory cell recruitment, thereby driving secondary brain injury. Although numerous neuroprotective and immunomodulatory agents have been explored for mitigating IRI, their brain penetration capacity and therapeutic efficacy are limited in part by the blood–brain barrier (BBB), which restricts drug accumulation within the brain parenchyma. To overcome this challenge, we developed a RONS-scavenging dendrimer, G4-PB-PEG, with prolonged systemic circulation and a RONS-responsive PEG shell. In the ischemic microenvironment with excessive RONS, stimulus-responsive PEG deshielding facilitates BBB penetration and lesion-selective accumulation, thereby enabling efficient scavenging of pathological RONS. In a mouse model of transient middle cerebral artery occlusion, intravenously administered G4-PB-PEG exhibited preferential accumulation at the cerebral lesion. By effectively scavenging RONS and attenuating neuroinflammatory responses, G4-PB-PEG significantly decreased infarct volume and the levels of neuroinflammation markers. Neurological outcomes also improved markedly, as quantified using the modified neurological severity score. These results indicate that G4-PB-PEG effectively alleviates cerebral IRI by facilitating BBB penetration and lesion-selective accumulation, with potent neuroprotective effects. Therefore, G4-PB-PEG warrants further evaluation for clinical translation.
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