STIMULATION of wound healing using bioinspired hydrogels with basic fibroblast growth factor bFGF

Earlier research suggests that bFGF is useful for stroke, only 19 fucking years ago. What the fuck will your doctor do with this new information to help your recovery?  Or will s/he continue to sit on their asses doing nothing with new or old research? Call the hospital president if such incompetency is displayed. Oops, once again telling Drs. and PhDs what needs to be done, thinking that my stroke-addled brain knows more about this stuff than they do.

Potential Usefulness of Basic Fibroblast Growth Factor as a Treatment for Stroke

written in 1999

STIMULATION of wound healing using bioinspired hydrogels with basic fibroblast growth factor bFGF 

Authors

Zhang X, Kang X, Jin L, Bai J, Liu W, Wang Z

22 March 2018

Accepted for publication

10 May 2018

Published

4 July 2018 Volume 2018:13 Pages 3897—3906

DOI

https://doi.org/10.2147/IJN.S168998

Checked for plagiarism

Yes

Single-blind

Peer reviewers approved by

Dr Thiruganesh Ramasamy

Peer reviewer comments

3

Editor who approved publication:

Dr Linlin Sun

Xiaoyu Zhang,¹ Xiaoning Kang,² Lijun Jin,¹ Jie Bai,¹ Wei Liu,¹ Zunyi Wang<sup>1

1</sup>Third Ward of Tumor Surgery Department, Cangzhou Central Hospital, Cangzhou, Hebei Province, People’s Republic of China; ²Third Ward of Ultrasound Department, Cangzhou Central Hospital, Cangzhou, Hebei Province, People’s Republic of China

Introduction: The objective of this study is to stimulate wound healing using bioinspired hydrogels with basic fibroblast growth factor (bFGF).
Materials and methods: Inspired by the crosslinking mechanism in algae-based adhesives, hydrogels were fabricated with gum arabic, pectin, and Ca²⁺. The physical properties of the bioinspired hydrogels were characterized, and the in vitro release of bFGF was investigated. Then, the in vitro scratch assay for wound healing and in vivo wound healing experiment in a full-thickness excision wound model were performed for the bioinspired hydrogels with bFGF. Finally, histological examinations and organ toxicity tests were conducted to investigate the wound healing applications of the bioinspired hydrogels with bFGF.
Results: The in vitro and in vivo results showed that the bioinspired hydrogels with bFGF could significantly enhance cell proliferation, wound re-epithelialization, collagen deposition, and contraction without any noticeable toxicity and inflammation compared with the hydrogels without bFGF and commercial wound healing products.
Conclusion: These results suggest the potential application of bioinspired hydrogels with bFGF for wound healing.

Keywords: bioinspired hydrogels, basic fibroblast growth factor, gum arabic, pectin, wound healing

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