But do you want to be slightly overweight because of this for your next stroke?
Obesity was associated with a longer survival time post stroke than normal
weight, while underweight was associated with a shorter survival time. Currently I fluctuate between 26.4 and 27.3 but then I'm no longer young.
Study suggests linear increase in risk of severe COVID-19 at BMI of more than 23, especially in younger adults
A study of more than 20,000 patients with coronavirus disease 2019 (COVID-19) who were hospitalised or died during the first wave found that the risk of worse outcomes from COVID-19 start increasing in people with a body mass index (BMI) >23 kg/m2, which is considered to be in the healthy range.
The findings are published in The Lancet Diabetes & Endocrinology.
For the study, researchers analysed records from QResearch database of general practices in England between January 24 and April 30, 2020 for outcomes linked to severe COVID-19 disease. They found that during the study period, 13,503 patients were admitted to hospital with COVID-19, 1,602 patients required treatment in the intensive care unit (ICU), and 5,479 patients died.
The study found non-linear associations between BMI and hospital admission and death due to COVID-19, and a linear association between BMI and ICU admission due to COVID-19. The risks of hospitalisation were 5% higher for each 1-unit increase in BMI (hazard ratio [HR] 1.05 [95% confidence interval {CI} 1.05–1.05]), while the risks of intensive care unit (ICU) admission and death were 10% higher (HR 1.10 [1.09–1.10]) and 4% higher (HR 1.04 [1.04–1.05]), respectively, for each unit increase in BMI in the fully adjusted model. On the other hand, spline models showed an increased HR for hospital admission and death due to COVID-19 among people with a BMI of less than 23 kg/m², although the association with ICU admission remained linear across the entire BMI range.
Additionally, the researchers observed a significant interaction between BMI and age (P < 0.0001 for all outcomes), whereby the effect of excess weight on the risk of severe COVID-19 was greatest in young people aged 20 to 39 years of age and decreased after age 60, with increasing BMI having very little impact on the risk of severe COVID-19 in people aged older than 80 years.
Among people aged 20–39 years, each BMI unit increase above 23 kg/m² was associated with an increased risk of hospital admission with an HR of 1.09 (95% CI 1.08–1.10), compared with HRs of 1.08 (1.07–1.09) among those aged 40-59, 1.04 (1.03–1.05) among those aged 60-79 and 1.01 (1.00–1.02) in those ≥80 years. Similarly, the risks of ICU admission (HR 1.13 [1.11–1.16]) and death (HR 1.17 [1.11–1.23]) were highest per 1-unit increase in BMI in those aged 20-39 years, compared with those aged 40-59 (ICU admission: HR 1.11 [1.10–1.13]; death 1.13 [1.11–1.15]), those aged 60-79 (ICU admission: HR 1.05 [1.04–1.07]; death: HR 1.03 [1.02–1.04]) and those aged ≥80 years (ICU admission: HR 1.06 [1.02–1.10]; death: HR 1.00 [0.99–1.01]).
Further, the researchers found that these outcomes were largely independent of other health conditions, including type 2 diabetes.
Meanwhile, a significant interaction between BMI and self-reported ethnicity (P <0.0001) was observed for hospital admission and death due to COVID-19, with Black people having a higher risk than White people for hospital admission due to COVID-19 (HR 1.07 [95% CI 1.06–1.08] vs 1.04 [1.04–1.05]) and for death due to COVID-19 (1.08 [1.06–1.10] vs 1.04 [1.03–1.04]). No difference was noted between other ethnic groups and those with self-reported White ethnicity for these outcomes.
“Our findings from this large population-based cohort emphasise that excess weight is associated with substantially increased risks of severe COVID-19 outcomes, and one of the most important modifiable risk factors identified to date,” wrote Min Gao, University of Oxford, Oxford, United Kingdom, and colleagues. “Even a small increase in BMI above 23 kg/m² is a risk factor for adverse outcomes after infection with severe acute respiratory syndrome coronavirus 2. People with excess weight, even without other comorbidities, are at substantially increased risk of admission to hospital and ICU and death due to COVID-19, especially for younger adults and Black people.”
“Although as yet unproven, interventions that reduce weight might reduce the risk of severe COVID-19 outcomes in individuals,” the authors added.
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