Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, May 18, 2021

The Effects of Aerobic Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in Stroke: A Systematic Review

This should have been totally uneccessary if we have a database of all stroke research and protocols that was updated every time new research comes in. But no, let's waste more time on these reviews rather than thinking and doing it correctly the first time.

The Effects of Aerobic Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in Stroke: A Systematic Review

ABSTRACT

Objective

To provide a novel overview of the literature and to summarise the evidence for the effects of aerobic exercise (AE) on serum biomarkers neuroplasticity and brain repair in stroke survivors.

Data Source

We conducted a systematic review and searched MEDLINE, EMBASE and Cochrane CENTRAL using terms related to AE, neuroplasticity, brain repair, and stroke.

Study Selection

Titles, abstracts, and selected full texts were screened by two independent reviewers against the following inclusion criteria: studies including adult stroke survivors, completing an AE intervention working within the AE capacity, with at least one blood biomarker outcome of interest measured.

Data Extraction

Two independent reviewers extracted data and assessed risk of bias using Risk of Bias In Non-randomised Studies – of Interventions (ROBINS-I) and Cochrane's Risk of Bias 2 (RoB 2) tools.

Data Synthesis

Nine studies (n=215 participants) were included, reporting on the following outcomes: brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), cortisol, interleukin-6 (IL-6) and myeloperoxidase (MPO). A single bout of high-intensity interval training significantly increased BDNF, IGF-1 and VEGF levels, and a 40-45-minute, 24-session, continuous eight-week AE training program significantly increased BDNF levels. No significant difference in response to any other AE intervention was found in other serum biomarkers.

Conclusion

AE can significantly increase BDNF, IGF-1 and VEGF across different AE protocols in stroke survivors. However, more research is needed to determine the optimal exercise intensity and modalities, specifically in acute and subacute stroke survivors, and how this may relate to functional outcomes.

 
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