Objective: 

The central-to-peripheral voluntary motor effort (VME) in physical practice of the paretic limb is a dominant force for driving functional neuroplasticity on motor restoration post-stroke. However, current rehabilitation robots isolated the central and peripheral involvements in the control design, resulting in limited rehabilitation effectiveness. The purpose of this study was to design a corticomuscular coherence (CMC) and electromyography (EMG)-driven (CMC-EMG-driven) system with central-and-peripheral integrated representation of VME for wrist-hand rehabilitation after stroke. 

Approach: 

The CMC-EMG-driven control was developed in a neuromuscular electrical stimulation (NMES)-robot system, i.e., CMC-EMG-driven NMES-robot system, to instruct and assist the wrist-hand extension and flexion in persons after stroke. A pilot single-group trial of 20 training sessions was conducted with the developed system to assess the feasibility for wrist-hand practice on the chronic strokes (n=16). The rehabilitation effectiveness was evaluated through clinical assessments, CMC, and EMG activation levels. 

Main results: 

The trigger success rate and laterality index (LI) of CMC were significantly increased in wrist-hand extension across training sessions (p<0.05). After the training, significant improvements in the target wrist-hand joints and suppressed compensation from the proximal shoulder-elbow joints were observed through the clinical scores and EMG activation levels (p<0.05). The central-to-peripheral VME distribution across upper extremity (UE) muscles was also significantly improved, as revealed by the CMC values (p<0.05). 

Significance: 

Precise wrist-hand rehabilitation was achieved by the developed system, presenting suppressed cortical and muscular compensation from the contralesional hemisphere and the proximal UE, and improved distribution of the central-and-peripheral VME on UE muscles.