You are already under high risk of getting dementia. What the fuck is your doctor EXACTLY doing to prevent that? This prevention is your doctor's responsibility, don't let them weasel out of it. You should get EXACT PROTOCOLS ON PREVENTION. Don't settle for crapola guidelines like the Mediterranean diet, that barely helps because there is no specificity to it.
Your chances of getting dementia.
2. Then this study came out and seems to have a range from 17-66%. December 2013.
Proton pump inhibitors (PPIs) are a class of drugs used to treat GERD, peptic ulcers, and H. pylori.
The currently available PPIs include:
omeprazole (Prilosec, Prilosec OTC, Zegerid)
lansoprazole (Prevacid)
pantoprazole (Protonix)
rabeprazole (Aciphex)
esomeprazole (Nexium)
dexlansoprazole (Dexilant)
First published: 08 May 2020
Abstract
Introduction
Several pharmacoepidemiological studies indicate that
proton pump inhibitors (PPIs) significantly increase the risk of
dementia. Yet, the underlying mechanism is not known. Here, we report
the discovery of an unprecedented mode of action of PPIs that explains
how PPIs may increase the risk of dementia.
Methods
Advanced in silico docking analyses and
detailed enzymological assessments were performed on PPIs against the
core‐cholinergic enzyme, choline‐acetyltransferase (ChAT), responsible
for biosynthesis of acetylcholine (ACh).
Results
This report shows compelling evidence that PPIs act as
inhibitors of ChAT, with high selectivity and unprecedented potencies
that lie far below their in vivo plasma and brain concentrations.
Discussion
Given that accumulating evidence points at cholinergic
dysfunction as a driving force of major dementia disorders, our
findings mechanistically explain how prolonged use of PPIs may increase
incidence of dementia. This call for restrictions for prolonged use of
PPIs in elderly, and in patients with dementia or amyotrophic lateral
sclerosis.
1 INTRODUCTION
The cholinergic system is one of the oldest and the most
widely spread neuronal and non‐neuronal signaling systems in the body,
and in an evolutionary perspective has acquired regulatory functions in
diverse biological processes and organs. The cholinergic neurons and
their projections are identified by intracellular presence of the
acetylcholine (ACh) bio‐synthesizing enzyme, choline‐acetyltransferase
(ChAT). All other downstream neurons and non‐excitable cells which
express ACh‐receptors are cholinoceptive cells. The central cholinergic
system consists of four “ChAT‐containing” neuronal nuclei (Ch1–Ch4)
located in the basal forebrain.
1
Ch1 and Ch2 innervate the hippocampal complex, Ch3 the olfactory bulb.
Ch4‐neurons are located in the nucleus basalis of Meynert (nbM), which
innervate the rest of cerebral cortex and amygdala.
1
These cholinergic nuclei and their widespread projections throughout
the brain have recently been mapped in detail as a 3D whole‐brain atlas
together with the morphology and the connectivity of individual neurons
from the basal forebrain.
2
In addition, extensive cholinergic neuronal projections, originated
from 13 cranial nerves (CN0 and I‐XII, constituting the parasympathetic
system
3), reach throughout the body, thereby controlling autonomic function of diverse organs, muscles, and glands.
4,
5
Another major neuronal system with extensive cholinergic circuitry is
the enteric nervous system (ENS), in which about 64% of the neurons are
cholinergic.
6
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