Sounds like a great idea to do some followup research on humans. But with NO LEADERSHIP ANYWHERE IN STROKE, nothing will occur.
Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage
Abstract
Perihematomal
edema (PHE) occurs within hours after intracerebral hemorrhage (ICH),
leading to secondary injury manifested by impaired blood-brain-barrier
(BBB) integrity and adjacent tissue destruction. To dissect mechanisms
underlying PHE formation, we profiled human and mouse perihematomal
tissues and identified natural killer (NK) cells as a predominant immune
cell subset that outnumbers other infiltrating immune cell types during
early stage of ICH. Unbiased clustering of single cell transcriptional
profiles revealed two major NK cell subsets in the brain following ICH
that possess either high cytotoxicity or robust chemokine production
features, which distinguish them from NK cells in the periphery. NK
cells exacerbate BBB disruption and brain edema after ICH via
cytotoxicity toward cerebral endothelial cells and recruitment of
neutrophils that augment focal inflammation. Thus, brain-bounding NK
cells acquire specific features that contribute to PHE formation and
neurological deterioration following ICH.(How do we stop this?)
- Copyright © 2020 by The American Association of Immunologists, Inc.
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