Deans' stroke musings: NLR–FAR Index as a superior predictor of 30-day functional outcome after endovascular thrombectomy in acute ischemic stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, May 12, 2026

NLR–FAR Index as a superior predictor of 30-day functional outcome after endovascular thrombectomy in acute ischemic stroke

Really? You don't know that predictions are totally fucking useless in guaranteeing recovery!

NLR–FAR Index as a superior predictor of 30-day functional outcome after endovascular thrombectomy in acute ischemic stroke

Xuchen Meng ^1,^†, Weijie Zhong ^1,^†, Dingzhong Tang ^2,^†, Zixian Mei ¹, Tanjun Deng ¹, Xin Lv ¹, Jiexi Xiao ¹, Yueqi Zhu ^3,^*, Yi Li ^1,^*

PMCID: PMC12975429 PMID: 41821631

Abstract

Objective

To determine whether the neutrophil-to-lymphocyte ratio–fibrinogen-to-albumin ratio (NLR–FAR) Index predicts long-term prognosis in acute ischemic stroke patients undergoing endovascular thrombectomy (EVT).

Introduction

Systemic inflammatory imbalance contributes to ischemic brain injury, but the combined effect of NLR and FAR on EVT outcomes has remained unclear.

Methods

We retrospectively analyzed patients treated with EVT. A composite inflammatory-coagulation index, designated as the NLR–FAR Index, was defined as the product of NLR and FAR. The primary endpoint was 30-day functional outcome defined by the modified Rankin Scale (mRS), with poor outcome as mRS ≥3. Logistic regression and restricted cubic spline analyses were used to assess associations.

Results

Of 254 patients, 121 (47.6%) had poor outcomes. Higher NLR, FAR, and especially NLR–FAR Index were significantly associated with poor prognosis. The NLR–FAR Index showed the strongest predictive effect (adjusted OR = 1.910, 95% CI: 1.079–3.384). Restrictive cubic spline analysis shows that when the NLR-FAR index exceeds the threshold of 0.62, the risk of adverse outcomes at 30 days begins to significantly increase.

Conclusion

The NLR–FAR Index independently predicts functional outcomes after EVT and outperforms NLR or FAR alone. This accessible biomarker may aid early risk stratification and individualized management in acute ischemic stroke.