Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, September 5, 2021

The Strength of the Corticospinal Tract Not the Reticulospinal Tract Determines Upper-Limb Impairment Level and Capacity for Skill-Acquisition in the Sub-Acute Post-Stroke Period

 But still useless, NOTHING on how to create strong ipsilesional CST connectivity.

Now write this up as a protocol and distribute this to all 10 million yearly stroke survivors  now and into the future. Just writing this article does nothing for survivors until you get it directly in their hands, not the therapists or doctors.

Your responsibility since we have fucking failures of stroke associations that can't even mange to do this simple thing for survivors. But then most stroke associations are not for survivors, they are to remove money from them and supposedly train doctors.

 

The Strength of the Corticospinal Tract Not the Reticulospinal Tract Determines Upper-Limb Impairment Level and Capacity for Skill-Acquisition in the Sub-Acute Post-Stroke Period

First Published July 4, 2021 Research Article Find in PubMed 

Background

Upper-limb impairment in patients with chronic stroke appears to be partly attributable to an upregulated reticulospinal tract (RST). Here, we assessed whether the impact of corticospinal (CST) and RST connectivity on motor impairment and skill-acquisition differs in sub-acute stroke, using transcranial magnetic stimulation (TMS)–based proxy measures. 

Methods

Thirty-eight stroke survivors were randomized to either reach training 3-6 weeks post-stroke (plus usual care) or usual care only. At 3, 6 and 12 weeks post-stroke, we measured ipsilesional and contralesional cortical connectivity (surrogates for CST and RST connectivity, respectively) to weak pre-activated triceps and deltoid muscles with single pulse TMS, accuracy of planar reaching movements, muscle strength (Motricity Index) and synergies (Fugl-Meyer upper-limb score).  

Results. Strength and presence of synergies were associated with ipsilesional (CST) connectivity to the paretic upper-limb at 3 and 12 weeks. Training led to planar reaching skill beyond that expected from spontaneous recovery and occurred for both weak and strong ipsilesional tract integrity. Reaching ability, presence of synergies, skill-acquisition and strength were not affected by either the presence or absence of contralesional (RST) connectivity.  

Conclusion. The degree of ipsilesional CST connectivity is the main determinant of proximal dexterity, upper-limb strength and synergy expression in sub-acute stroke. In contrast, there is no evidence for enhanced contralesional RST connectivity contributing to any of these components of impairment. In the sub-acute post-stroke period, the balance of activity between CST and RST may matter more for the paretic phenotype than RST upregulation per se.

Motor impairment after stroke is closely associated with ipsilesional corticospinal tract (CST) damage.1-4 In addition, recent data suggest that arm flexor synergies, finger enslaving on the paretic side and mirror movements on the non-paretic hand after stroke are all attributable to an increased influence of the reticulospinal tract (RST) after damage to the CST.5-11 Studies in primates have shown that 6 months after a lesion in the pyramidal tract,12 there is upregulation of the RST. In patients with chronic stroke, the incidence of contralesional connectivity to the ipsilateral paretic limb is increased, particularly in patients with moderate to severe paresis,13,14 suggesting a similar upregulation of RST activity during recovery.15 An unanswered question is the impact of this RST upregulation after the initial plegic stage3; does it contribute to, or impede recovery, or is it an epiphenomenon of recovery, neither good nor bad.7 Furthermore, it is unclear whether unwanted muscle synergies result from actual upregulation of pre-existing cortico-reticulospinal descending pathways or can be attributed instead to a relative imbalance between them (in the absence of upregulation) and the CST.6

Using transcranial magnetic stimulation (TMS), we sought to determine the degree of ipsilesional and contralesional cortical connectivity to paretic arm muscles in a group of patients with moderate to severe stroke in the early sub-acute period. TMS of the human motor cortex in one hemisphere can evoke responses in ipsilateral muscles with characteristics compatible with activation of oligosynaptic cortico-bulbospinal pathways,16 most likely representing cortico-reticulo-spinal connection.13,14,17-19 This provides an indirect method of assessing the excitability of the RST in stroke survivors.11,20-22 We further investigated the effect of these two forms of connectivity on strength, synergies, planar reaching accuracy and capacity for skill-acquisition. We examined inputs to proximal muscles involved in planar reaching movements since these are thought to receive greater reticulospinal inputs than distal arm muscles.16,23

 

Compensatory Effects of Sequential 4-Channel Neuromuscular Electrical Stimulation for the Treatment of Acute, Subacute, and Chronic Dysphagia in a Prospective, Double-Blinded Randomized Clinical Trial

So write this up as a protocol and deliver is to all 10 million yearly stroke survivors

  now and into the future.

That would normally be the responsibility of stroke associations but we have fucking failures of stroke associations  instead, so the responsibility falls on your researchers.

 

Compensatory Effects of Sequential 4-Channel Neuromuscular Electrical Stimulation for the Treatment of Acute, Subacute, and Chronic Dysphagia in a Prospective, Double-Blinded Randomized Clinical Trial

First Published July 4, 2021 Research Article Find in PubMed 

Background. 

The precise mechanism of 2-channel neuromuscular electrical stimulation (NMES) treatment is unknown, and controversy remains over its efficacy. The sequential 4-channel NMES was newly developed based on normal contractile sequences of swallowing-related muscles.  

Objective. 

To assess the clinical efficacy of sequential 4-channel NMES during swallowing.  

Methods. 

In this prospective RCT, 52 inpatients with dysphagia (acute, subacute, and chronic state) after stroke, brain tumor, or encephalitis were enrolled. Participants who underwent a videofluoroscopic swallowing study (VFSS) and clinical evaluation were enrolled and were randomly assigned to the 4-channel NMES or sham group. The 4-channel NMES and sham groups swallowed thin and honey-like fluids under NMES (sequential stimulation on suprahyoid and infrahyoid) and sham stimulation, respectively. The procedures were evaluated with the VFSS. Pre- and post-treatment evaluations were performed with the videofluoroscopic dysphagia scale (VDS), penetration–aspiration scale (PAS), Likert scale, and kinematic analysis.  

Results. 

The 4-channel NMES group showed significantly greater improvements than the sham group with respect to oral VDS, pharyngeal VDS, total VDS, and PAS (P < .05). Furthermore, the Likert scale for satisfaction, easiness, and discomfort for swallowing showed favorable results for the 4-channel NMES group (P < .05). In the kinematic analysis, the peak speed point, distance, and velocity of hyoid movement were significantly greater in the 4-channel NMES group (P < .05). 

Conclusions. 

Sequential 4-channel NMES activating the suprahyoid, thyrohyoid, and other infrahyoid muscles during swallowing showed significant clinical improvement with respect to VDS, PAS, and kinematic analysis. Therefore, sequential 4-channel NMES is a potential new functional electrical stimulation system for the treatment of dysphagia.

 

Effect of Transcutaneous Electrical Stimulation in Chronic Poststroke Patients with Oropharyngeal Dysphagia: 1-Year Results of a Randomized Controlled Trial

 

Is this enough to get written in a protocol and distributed to all stroke hospitals? Or will it fall by the wayside since we have fucking failures of stroke associations  doing nothing to get research into the real world? And once again waste time and money?

Effect of Transcutaneous Electrical Stimulation in Chronic Poststroke Patients with Oropharyngeal Dysphagia: 1-Year Results of a Randomized Controlled Trial

First Published June 17, 2021 Research Article Find in PubMed 

Background

Chronic poststroke oropharyngeal dysphagia (CPSOD) is associated with impaired oropharyngeal sensory/motor function. We aimed to assess effect of sensory (SES) and motor (NMES) transcutaneous electrical stimulation (TES) on safety of swallow and clinical outcomes in patients with CPSOD in a one-year follow-up randomized controlled trial.  

Methods

Ninety patients (74.1 ± 11.5 y, modified Rankin score 2.6 ± 1.7) with CPSOD and impaired safety of swallow were randomized to (a) compensatory treatment (CT), (b) CT + SES, and (c) CT + NMES. Patients were treated with up to two cycles (6 months apart) of 15 × 1 hour TES sessions over two weeks and followed up with 4-5 clinical and videofluoroscopic assessments during one year.  

Key results

Baseline penetration–aspiration scale (PAS) was 4.61 ± 1.75, delayed time to laryngeal vestibule closure (LVC) 396.4 ± 108.7 ms, and impaired efficacy signs 94.25%. Swallowing parameters significantly improved between baseline and 1-year follow-up in SES and NMES groups for prevalence of patients with a safe swallow (P < .001), mean PAS (P < .001), time to LVC (P < .01), and need for thickening agents (P < .001). Patients in the CT presented a less intense improvement of signs of impaired safety of swallow without significant changes in time to LVC. No differences between groups were observed for 1-year mortality (6.1%), respiratory infections (9.6%), nutritional and functional status, QoL, and hospital readmission rates (27.6%). No significant adverse events related to TES were observed.  

Conclusions and inferences

Transcutaneous electrical stimulation is a safe and effective therapy for older patients with CPSOD. After 1-year follow-up, TES greatly improved the safety of swallow and reduced the need for fluid thickening in these patients.

 

Saturday, September 4, 2021

Slow Breathing Is the Fastest Way To Calm Your Brain and Body for anxiety by Debbie Hampton

But fast breathing creates nitric oxide,  the Kundalini Breath of Fire from 5 years ago which produces nitric oxide thus dilating your blood vessels?

Which is more important? Your doctor should know the answer.

 Slow Breathing Is the Fastest Way To Calm Your Brain and Body for anxiety by Debbie Hampton

Implicit and explicit motor learning interventions have similar effects on walking speed in people after stroke: A randomized controlled trial.

 So write this up as a protocol and deliver is to all 10 million yearly stroke survivors

now and into the future.

That would normally be the responsibility of stroke associations but we have fucking failures of stroke associations  instead, so the responsibility falls on your researchers.

 Implicit and explicit motor learning interventions have similar effects on walking speed in people after stroke: A randomized controlled trial.

Physical Therapy , Volume 101(5)

NARIC Accession Number: J86611.  What's this?
ISSN: 0031-9023.
Author(s): Jie, Li-Juan; Kleynen, Melanie Meijer, Kenneth; Beurskens, Anna ; Braun, Susy.
Publication Year: 2021.
Number of Pages: 10.

Abstract: 

Study assessed whether an implicit motor learning walking intervention is more effective compared with an explicit motor learning walking intervention delivered at home regarding walking speed in people after stroke in the chronic phase of recovery. Explicit motor learning can be referred to as a more conscious form of learning characterized by the generation of verbal knowledge and involvement of cognitive resources. In contrast, implicit motor learning is assumed to take place without much knowledge of the underlying facts and rules of motor skills. In a randomized, controlled, single-blind trial, 79 participants, who were more than 6 months post stroke, were randomly assigned to an implicit or explicit group. Analogy learning was used as the implicit motor learning walking intervention, whereas the explicit motor learning walking intervention consisted of detailed verbal instructions. Both groups received 9 training sessions (30 minutes each), for a period of 3 weeks, targeted at improving quality of walking. The primary outcome was walking speed measured by the 10-MeterWalk Test at a comfortable walking pace. Outcomes were assessed at baseline, immediately after intervention, and 1 month post intervention. No statistically or clinically relevant differences between groups were obtained postintervention (between-group difference was estimated at 0.02 meters per second (m/s) and at follow-up (between-group difference estimated at −0.02 m/s). Implicit motor learning was not superior to explicit motor learning to improve walking speed in people after stroke in the chronic phase of recovery. Results indicate that physical therapists can use implicit and explicit motor learning strategies to improve walking speed in people after stroke who are in the chronic phase of recovery.
Descriptor Terms: AMBULATION, INTERVENTION, LEARNING, MOBILITY TRAINING, MOTOR SKILLS, PHYSICAL THERAPY, STROKE.


Can this document be ordered through NARIC's document delivery service*?: Y.

Citation: Jie, Li-Juan, Kleynen, Melanie Meijer, Kenneth, Beurskens, Anna , Braun, Susy. (2021). Implicit and explicit motor learning interventions have similar effects on walking speed in people after stroke: A randomized controlled trial.  Physical Therapy , 101(5) Retrieved 8/26/2021, from REHABDATA database.

White matter integrity is a stronger predictor of motor function than BOLD response in patients with stroke

Recovery prediction like this is useless since there are no protocols given that will create white matter integrity.  All you are doing is predicting failure to recover and there is not a single stroke survivor in the world that wants to hear that.

White matter integrity is a stronger predictor of motor function than BOLD response in patients with stroke

 
First Published February 25, 2011 Research Article Find in PubMed 

Objective

 Neuroimaging techniques, such as diffusion tensor imaging (DTI) and blood oxygenation level–dependent (BOLD) functional magnetic resonance imaging (fMRI), provide insights into the functional reorganization of the cortical motor system after stroke. This study explores the relationship between upper extremity motor function, white matter integrity, and BOLD response of cortical motor areas.  

Methods

Seventeen patients met study inclusion criteria; of these 12 completed DTI assessment of white matter integrity and 9 completed fMRI assessment of motor-related activation. Primary clinical outcome measures were the Wolf Motor Function Test (WMFT) and the upper limb portion of the Fugl-Meyer (FM) motor assessment. Structural integrity of the posterior limb of the internal capsule was assessed by examining the fractional anisotropy (FA) asymmetry in the PLIC. Laterality index of motor cortical areas was measured as the BOLD response in each patient during a finger pinch task. Linear regression analyses were performed to determine whether clinical outcome was associated with structural or functional MRI measures. 

Results

There were strong relationships between clinical outcome measures and FA asymmetry (eg, FM score [R2 = .655, P = .001] and WMFT asymmetry score [R2 = .651, P < .002]) but relationships with fMRI measures were weaker.  

Conclusion

Clinical motor function is more closely related to the white matter integrity of the internal capsule than to BOLD response of motor areas in patients 3 to 9 months after stroke. Thus, use of DTI to assess white matter integrity in the internal capsule may provide more useful information than fMRI to interpret motor deficits following supratentorial brain injury.

Central mechanisms underlying upper limb motor recovery following stroke remain poorly understood. Clinical observations suggest that the initial levels of motor deficit and the course of recovery depend on corticofugal projection fiber integrity.1-5 Diffusion tensor imaging (DTI) can appraise the integrity of white matter tracts by recording the fractional anisotropy (FA), which is derived from the eigenvalues of the diffusion tensor, to localize changes in white matter integrity due to local tissue damage or Wallerian degeneration after stroke.6 Furthermore, comparing the FA value of a well-defined pathway on one side of the neuraxis with the homologous pathway on the opposite side for signs of asymmetry provides insight toward the integrity and general health of a potentially injured or structurally declining white matter pathway. For instance, studies examining stroke patients with small homogeneous subcortical infarcts have found that larger asymmetries in FA are associated with poor motor recovery of the limb subserved by the injured pathway.7 Indeed, recent observations suggest that the potential for motor function recovery declines with increasing corticospinal tract disruption in stroke patients,8,9 with no clinically meaningful gains appearing if DTI-derived FA asymmetry values exceed 0.25.10

Functional magnetic resonance imaging (fMRI) has provided important insights into the reorganization of the motor cortices after stroke.11-13 The reported fMRI-derived patterns of motor system activation following stroke are variable and their interpretation regarding the recovery process is controversial.14-17 Some studies suggest that positive motor recovery correlates with activation of the ipsilesional lateral premotor and supplementary motor areas when performing movements of the affected limb following stroke, particularly when the primary motor cortex (M1) is involved in the damage.14,15 However, other reports suggest that bilateral patterns of cortical activity are associated with more favorable levels of motor recovery than ipsilesional activation alone, implicating a role for the contralesional motor areas in the recovery process.17,18 Patients with good upper limb recovery after stroke have a significantly lower laterality index (LI) during finger tapping19 (ie, higher contralesional activity) than able-bodied volunteers, indicating relatively greater activation and potential contribution of the unaffected primary sensorimotor cortex (SM1). Conversely, poorly recovered chronic stroke patients exhibit low LI values.20 However, these differences in LI values may subtend proportional differences in recovery stage since those in the Cramer et al19 study were 11 days to 15 months poststroke (combined acute and chronic phases or recovery), whereas Carey et al20 enrolled patients who were 10 months to 21 years poststroke (all in chronic phase of recovery).

Although these studies have provided insight into recovery mechanisms after stroke, the specific neural substrates mediating recovery of hand motor function are not completely understood. Recent data suggest that pyramidal tract integrity is a strong predictor for focusing activation within affected primary sensorimotor cortex.21 The question remains as to the relative importance of the contribution of the cortical motor areas and their corticofugal projection systems to upper limb recovery following stroke. Furthermore, the relationship between motor system activation and white matter integrity remains poorly understood.13 The aim of the present study was to test the hypothesis that FA asymmetry in the posterior limb of the internal capsule (PLIC) and LI of the cortical motor areas are associated with upper limb motor functional outcomes in hemiparetic patients following stroke. Indeed, it is well known that the corticofugal projection from the frontal motor cortices to cervical spinal cord levels reside within the PLIC1,22 and PLIC damage in humans results in upper extremity functional deficits.1,4,5 We hypothesized that the degree of affected upper limb motor function will be correlated with FA asymmetry of PLIC and laterality of activated voxels in primary motor cortex in hemiplegic patients with moderate motor impairment 3 to 9 months poststroke. Specifically, superior motor function with the hemiplegic hand will be associated with lower FA asymmetry (ie, better integrity of PLIC) and higher LI (ie, higher ipsilesional activity).

 

Extracellular Vesicles in Regeneration and Rehabilitation Recovery after Stroke

 Have your doctor analyze this and see how this will get you 100% recovered. It is your responsibility to make sure your doctor understands that the only goal in stroke is 100% recovery. And you expect her/him to have EXACT STROKE PROTOCOLS TO GET THERE!

Extracellular Vesicles in Regeneration and Rehabilitation Recovery after Stroke

Alice Gualerzi *, Silvia Picciolini , Francesca Rodà and Marzia Bedoni


Citation: Gualerzi, A.; Picciolini, S.;
Rodà, F.; Bedoni, M. Extracellular
Vesicles in Regeneration and
Rehabilitation Recovery after Stroke.
Biology 2021, 10, 843.
https://doi.org/
10.3390/biology10090843
Academic Editors: Simona Bernardi
and Carolina Balbi
Received: 20 July 2021
Accepted: 25 August 2021
Published: 30 August 2021
Publisher’s Note: MDPI stays neutral
with regard to jurisdictional claims in
published maps and institutional affiliations.
Copyright: © 2021 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/).
IRCCS Fondazione Don Carlo Gnocchi Onlus, 20148 Milan, Italy; spicciolini@dongnocchi.it (S.P.);
froda@dongnocchi.it (F.R.); mbedoni@dongnocchi.it (M.B.)
* Correspondence: agualerzi@dongnocchi.it; Tel.: +39-02-4030-8533
Simple Summary: Patients that survive after a stroke event may present disabilities that can persist
for a long time or permanently after it. Clinical intervention with pharmacological and rehabilitation
therapies must follow the correct timing and dosing to guarantee optimal recovery of the patients.
Extracellular vesicles are nanometric cell products that can be detected in body fluids such as blood
and urine; their use as biomarkers for the personalization of stroke therapy and rehabilitation
(rehabilomics) might help clinicians and patients to reach the optimal recovery and ameliorate patient
quality of life. Moreover, extracellular vesicles released by cells such as stem cells or other human
cells are under investigation for their possible regenerative role that could be coupled to standard
therapies to stimulate brain remodeling and ameliorate the recovery after stroke. In this review
we describe some of the most recent advancements in the field and discuss the potentialities of
extracellular vesicles in brain regeneration and rehabilitation after stroke.

Abstract:

Patients that survive after a stroke event may present disabilities that can persist for a long
time or permanently after it. If stroke prevention fails, the prompt and combinatorial intervention
with pharmacological and rehabilitation therapy is pivotal for the optimal recovery of patients and
the reduction of disabilities. In the present review, we summarize some key features of the complex
events that occur in the brain during and after the stroke event, with a special focus on extracellular
vesicles (EVs) and their role as both carriers of biomarkers and potential therapeutics. EVs have
already demonstrated their ability to be used for diagnostic purposes for multiple brain disorders
and could represent valuable tools to track the regenerative and inflammatory processes occurring in
the injured brain after stroke. Last, but not least, the use of artificial or stem cell-derived EVs were
proved to be effective in stimulating brain remodeling and ameliorating recovery after stroke. Still,
effective biomarkers of recovery are needed to design robust trials for the validation of innovative
therapeutic strategies, such as regenerative rehabilitation approaches.

Number of people with dementia expected to rise 40% within decade, WHO says

 With the extra risk created by your stroke you need your stroke hospital to initiate research that can prevent dementia.

Your risk of dementia, has your doctor told you of this?

1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.

2. Then this study came out and seems to have a range from 17-66%. December 2013.`    

3. A 20% chance in this research.   July 2013.

4. Dementia Risk Doubled in Patients Following Stroke September 2018

The latest here:

Number of people with dementia expected to rise 40% within decade, WHO says

The number of people worldwide suffering from dementia is expecting to rise to 78 million by 2030, according to a report published Thursday by the World Health Organization.

That’s a 40% increase from the estimated number of people worldwide currently suffering from the neurological disorder. As populations age, the number of people with dementia is expected to rise to a whopping 139 million by 2050, the WHO said.

Dementia can be caused by a variety of diseases or injuries that affect the brain like a stroke, brain injury or Alzheimer’s disease. It is currently the seventh leading cause of death among all diseases and a major cause of disability and dependency among older people.


While there is no treatment, developing dementia is not an inevitable consequence of aging, the WHO said. Numerous studies have shown the risk of acquiring it can be reduced by staying physically active, not smoking, drinking moderately, and maintaining a healthy diet.

The expected rising numbers of people with dementia will have significant social and economic consequences. In 2019, the estimated total global societal cost of dementia was $1.3 trillion. Those costs are expected to be nearly $3 trillion by 2030 as the number of people living with dementia and care costs increase.

 

Early Intensive Multi-faceted Rehabilitation in Stroke Patients: What is the Best Effective Rehabilitation Time?

 

Still NO PROTOCOLS on stroke rehab. Your doctors and therapists are just guessing about what to do. With their tyranny of low expectations they can justify failure to 100% recover.


Early Intensive Multi-faceted Rehabilitation in Stroke Patients: What is the Best Effective Rehabilitation Time?

  • Source: Journal of Physical Medicine & Rehabilitation Sciences / Fiziksel Tup ve Rehabilitasyon Bilimleri Dergisi . 2021, Vol. 24 Issue 3, p267-276. 10p.
  • Author(s): SERÇE, Azize; UMAY, Ebru KARACA; ÇAKÇI, Fatma Aytül
  • Abstract: 
          Objective: 
We aimed to evaluate the effects of the intensive and multi-faceted rehabilitation program in patients during the first 3 weeks after stroke, and to determine the most effective time to initiate treatment. Material and Methods: Forty two patients who were treated in our clinic were included in the study. The demographic characteristics of the patients, the level of stroke severity assessed by the National Stroke Institute Severity Scale (NIHSS), the functional stages assessed by the Brunstrom and Chedocke McMaster Stroke Assesment (CMSA) Scale and the disability levels assessed by the Functional Independence Measure scale were recorded. All patients received a multi-faceted and intensive rehabilitation program 20 sessions in total. The patients were divided into 3 groups according to the times of initiation of rehabilitation i.e during the first 9 days (Group 1), between days 10 and 14 (Group 2) and between days 15 and 21 (Group 3). The evaluation parameters assessed before the treatment, 4th weeks and 3th months were compared within and between the groups. 
Results: 
According to the treatment start times; the change in CMMS hand, arm, legand postural control scores, Brunstroom upper, lower limbs and hand levels and the NIHSS score was found to be higher in the first 9 days compared to the other 2 groups in the beginning of treatment. 
Conclusion: 
Early intensive and multifaceted rehabilitation program is effective for motor and functional recovery in ischemic stroke patients. Moreover, the start of treatment within the first 9 days provides the most improvement.
  • Copyright of Journal of Physical Medicine & Rehabilitation Sciences / Fiziksel Tup ve Rehabilitasyon Bilimleri Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.

For access to this entire article and additional high quality information, please check with your college/university library, local public library, or affiliated institution.

 

Molecular, cellular and functional events in axonal sprouting after stroke

 You need axonal sprouting so go ask your doctor for protocols that deliver it.

Molecular, cellular and functional events in axonal sprouting after stroke

BalachandarKathirveluCatherine A.SchweppeEsther H.Nie

Highlights

Stroke induces the formation of new connections in brain and spinal cord.

These mediate some aspects of motor recovery.

A unique molecular program, a regenerative transcriptome, underlies post-stroke axonal sprouting.

Axonal sprouting occurs in three different patterns: reactive, reparative and unbounded.

Each pattern of post-stroke axonal sprouting has unique relationships to behavioral activity and molecular control points.

Abstract

Stroke is the leading cause of adult disability. Yet there is a limited degree of recovery in this disease. One of the mechanisms of recovery is the formation of new connections in the brain and spinal cord after stroke: post-stroke axonal sprouting. Studies indicate that post-stroke axonal sprouting occurs in mice, rats, primates and humans. Inducing post-stroke axonal sprouting in specific connections enhances recovery; blocking axonal sprouting impairs recovery. Behavioral activity patterns after stroke modify the axonal sprouting response. A unique regenerative molecular program mediates this aspect of tissue repair in the CNS. The types of connections that are formed after stroke indicate three patterns of axonal sprouting after stroke: reactive, reparative and unbounded axonal sprouting. These differ in mechanism, location, relationship to behavioral recovery and, importantly, in their prospect for therapeutic manipulation to enhance tissue repair.


Sexual Satisfaction and Associated Biopsychosocial Factors in Stroke Patients Admitted to Specialized Cognitive Rehabilitation

 The real problem you are not addressing is getting back to 100% recovery then you wouldn't have to address this secondary problem. Will you please focus on the correct and only goal in stroke? 100% recovery.

Sexual Satisfaction and Associated Biopsychosocial Factors in Stroke Patients Admitted to Specialized Cognitive Rehabilitation

Under a Creative Commons license
open access

ABSTRACT

Introduction

The consequences of stroke on sexual life in stroke patients in need of specialized cognitive rehabilitation have been limited explored. A biopsychosocial perspective in post-stroke sexuality studies is warranted to capture the complex picture of stroke consequences and sexual life after stroke and sexual satisfaction is an important outcome measure when exploring such multifactorial associations.

Aim

To explore sexual satisfaction and associated biopsychosocial factors in stroke patients admitted to specialized cognitive rehabilitation.

Methods

A cross-sectional study was performed including 91 consecutive stroke patients admitted to specialized cognitive rehabilitation. Data were collected from medical records and by face-to-face interviews using a structured interview guide and questionnaires. Descriptive and inferential statistics were applied.

Main outcome measures

A wide range of biopsychosocial variables including medical and sociodemographic characteristics, social support, sexual complaints, aspects of sexual life, psychological distress and life satisfaction were analyzed in relation to the main outcome “Satisfaction with sexual life.”

Results

Only 33 % were satisfied with sexual life. Prevalence of sexual complaints was high, more frequent in women (84%) than in men (64%). Three-quarters were less sexually active than before stroke. Multivariable analyses showed that anxiety, sleep problems, manifested sexual complaint, decrease in sexual activity and fear of partner rejection were significantly associated with low odds of sexual satisfaction, while affectionate support and partnership satisfaction were significant for sexual satisfaction. When combined in a biopsychosocial multivariable model only fear of partner rejection (OR 0.07; 95 % CI: 0.01–0.42) and decrease in sexual activity (OR 0.11; 95 % CI: 0.02–0.58) showed significant contribution to sexual satisfaction.

Conclusion

The variety of predictors for sexual satisfaction indicates that therapeutic actions need to be individualized and points towards a broad assessment and interventional approach to meet the sexual rehabilitation needs of stroke patients with cognitive impairments in need of specialized rehabilitation.

Vikan JK, Snekkevik H, Nilsson MI, et al. Sexual Satisfaction and Associated Biopsychosocial Factors in Stroke Patients Admitted to Specialized Cognitive Rehabilitation. Sex Med 2021;XX:XXXXXX.

 

The Rehabilitative Effects of Guided Motor Imagery on Gait and Balance in Older Adults

 This doesn't refer to any protocol that will prevent falls so go ask your doctor for one. It better exist or your doctor is not worth it.

The Rehabilitative Effects of Guided Motor Imagery on Gait and Balance in Older Adults

  INTRODUCTION

Falls are a leading cause of injury, disability, nursing home admission, and death among older adults (Bohl, Gill, Shumway-Cook, Tinetti). Each year about one-third of community-dwelling adults, 65 years of age or older, fall at least once. Among those aged 80 years or older, the percentage is 50% (Inouye). As a result, identifying cost-effective interventions to reduce the risk of falls among older adults continues to be a focus of intense inquiry (Bruce, Matchar)Strengthening exercises, balance training, and gait training are evidence-based interventions used by physical therapists to reduce fall-risk (Matchar). However, the efficacy of motor imagery (MI) has been investigated as another means of improving functional performance.MI is the cognitive practice of a physical skill in the absence of gross motor movement(Fansler, Nakano). Positive results have been reported for more than two decades on the use of MI to improve several aspects of motor performance in athletes (Driediger, MacIntyre, Taktek) and non-athlete adults to improve motor performance (Dickstein, Nakano). Few studies have focused on the use of MI in the following conditions: independent of physical practice, in the treatment of gait or balance dysfunctions in older adults without a primary neuromuscular condition (such as stroke or PD) (Deutsch), or in the treatment of gait and balance dysfunctions concurrently.

 Motor Imagery:

Learning or improving motor skills relies upon neuroplasticity(Warner). Motor imagery techniques involve imagining oneself correctly performing a particular motor skill while simultaneously focusing on the physical demands of the skill’s performance. This imagined movement recruits a subcortical network similar to that recruited for movement execution (Hardwick). Such recruitment manifests action potentials and minute muscular contractions, which facilitates movement (Debarnot, Ehrsson, Warner). MI allows patients to mentally rehearse movements, begin the healing process, and potentially reduce total recovery time (Warner). Vividly imagined motor ability is theorized to affect a person’s perceptions of actual ability, including belief in their ability to perform the activity, in a way similar to that of actually having demonstrated the performance(Debarnot, Ehrsson). Researchers suggest that much motor success is predicated upon perceptions, attitudes, and expectations, all of which can bealtered with the proper mental imagery and guidance (Benz, Berdik, Evans, Warner). Neuroimaging studies have found white matter to increase and the following motor areas of the brain to be active during motor imagery interventions: the SMA, left primary motor cortex, the left prefrontal cortex, the right thalamus and the cerebellum, all of which are highly correlated with successful gait performance (Debarnot, Nakano).

METHODS

Participants:
Men and women aged 65 years or older with self-reported difficulties with gait and balance were recruited from the independent and assisted-living residents of a local retirement center in North Carolina. Participants were excluded if they had cognitive or vestibular impairments(such as advanced dementia or vertigo), if they had had physical therapy (PT) for balance or gait within 3 months prior to the study, or if they were completely unable to stand or walk.The use of an assistive gait device did not exclude participants from this study.Eleven participants were accepted into the study. One participant dropped out of the study due to scheduling difficulties, and one after developing pneumonia; leaving 9 participants ranging in age from 73 to 95 years old.
Study Design:
Participants were randomly assigned to one of two groups: MI or PT. The MI group comprised 4 females and 1 male, with an average age of 85 years old. The PT group consisted of 3 females and 1 male, with an average age of 90 years old.Participants were asked to take part in 3 treatment sessions over a one-week period and return 1 week later for retention testing.
 Treatment Interventions:
The PT group was treated by a licensed physical therapist and APTA certified Geriatric Clinical Specialist who employed active gait and balance therapeutic activities within a 20-minute treatment session, 3 days during 1 week. The interventions were chosen to represent conventional gait and balance interventions: single leg stance, standing on a foam pad with eyes open and eyes closed, lower extremity strengthening, braiding, and gait with obstacles. Although activities were similar across participants, the level of difficulty was individualized to create a challenging intervention for each participant.Participants in the MI group were treated by listening to an MI script that guided participants through the mental practice of functional balance and gait. Participants were instructed to sit upright in a chair with feet flat on the floor and to keep their eyes closed during the script reading. They were informed that no physical movement was required during the intervention. The script was read by one of the experimenters to the participants on 3 days during 1 week.Each treatment for the MI group lasted about 15 minutes.No home regimen was prescribed for either group.
Assessments:
The subjects were each assessed with performance outcome measures preintervention for baseline, postintervention to determine effectiveness,and 1 week following intervention completion to assess retention.These assessments were chosen specifically for gait and balance to determine the subjects’ fall risk and assess confidence in independently performing such tasks(Middleton, Wallace). The assessments used were the Activities Specific Balance Confidence (ABC) Scale for self reported confidence and fear of falling, the Timed Up and Go (TUG) test as a widely accepted outcome measure for fall-risk and mobility, and the Short-Form Berg Balance as one of the most commonly used outcome measures for functional balance. The data were analyzed using one-way ANOVA, MCDs, and visual assessment for trends between groups.