A review of remote ischemic conditioning as a potential strategy for neural repair poststroke

And all this earlier research was not enough to realize that the next step was to create protocols on this rather than repeat research? So we had to waste more time and money better spent solving stroke problems?

• leg compressions (16 posts to September 2015)

  Remote ischemic conditioning (11 posts to July 2018)

   

• leg wraps (7 posts to May 2013)

 

 A review of remote ischemic conditioning as a potential strategy for neural repair poststroke

Wantong Yu1| Changhong Ren1,2| Xunming Ji1,2This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.© 2022 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.Abbreviations: AIS, Acute ischemic stroke; Ang, Angiotensin; BDNF, brain-derived neurotrophic factor; CNS, central nervous system; eNOS, endothelial nitric oxide synthase; EPO, erythropoietin; GAP-43, growth-associated protein 43; HIF-1, Hypoxia inducible factor-1; iNOS, inducible nitric oxide synthase; LTD, long-term depression; LTP, long-term potentiation; mTOR, mammalian target of rapamycin; Ngb, neuroglobin; NO, nitric oxide; OPC, oligodendrocyte precursor cell; PSD95, Postsynaptic density protein-95; p- STAT3, signal transducer and activator of transcription 3 phosphorylation; RIC, Remote ischemic condition; STAT3, signal transducer and activator of transcription 3; SYN, Synaptophysin; Treg, regulatory T cell; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor 2.1Department of Neurology and Beijing Key Laboratory of Hypoxia Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China2Center of Stroke, Beijing Institute for Brain Disorder, Capital Medical University, Beijing, ChinaCorrespondenceXunming Ji, Center of Stroke, Beijing Institute for Brain Disorder, Capital Medical University, Beijing 100069, China.Email: jixm@ccmu.edu.cnFunding informationNational Natural Science Foundation of China, Grant/Award Number: 81971114 and 81801313 

Abstract

Ischemic stroke is one of the major disabling health-care problem and multiple different approaches are needed to enhance rehabilitation, in which neural repair is the structural basement. Remote ischemic conditioning (RIC) is a strategy to trigger endogenous protect. RIC has been reported to play neuroprotective role in acute stage of stroke, but the effect of RIC on repair process remaining unclear. Several studies have discovered some overlapped mechanisms RIC and neural repair performs. This review provides a hypothesis that RIC is a potential therapeutic strategy on stroke rehabilitation by evaluating the existing evidence and puts forward some remaining questions to clarify and future researches to be performed in the fiel