Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, March 10, 2026

Detecting major neurological disorders via saliva

With your risk of Parkinsons and epilepsy post stroke, your competent? doctor will immediately implement these tests so appropriate prevention protocols can be initiated, right? Oh NO, you DON'T have a functioning stroke doctor, do you? Doesn't read or implement research! And your incompetent? board of directors can't identify incompetence to be able to fire them!

 Detecting major neurological disorders via saliva

A team of Korean researchers has, for the first time in the world, developed a technology capable of enabling early diagnosis of major neurological disorders, including epilepsy, Parkinson's disease, and schizophrenia, using only a small amount of saliva.

This study was conducted jointly by a research team led by Dr. Sung-Gyu Park of the Advanced Bio and Healthcare Materials Research Division at the Korea Institute of Materials Science (KIMS), together with Prof. Ho Sang Jung's team at Korea University and researchers from the College of Medicine at The Catholic University of Korea. The research has recently been published in Advanced Materials, one of the world's leading journals in the field of materials science, drawing significant international attention.

The joint research team developed a Galvanic Molecular Entrapment (GME)–SERS platform that directly detects structural changes in proteins using saliva, replacing conventional diagnostic methods based on blood or cerebrospinal fluid that are costly and invasive. This technology leverages plasmonic "hotspots" that form naturally as proteins are captured on nanostructures composed of copper oxide and gold (Au–CuO).


A key feature of the platform is its ability to amplify the extremely weak Raman signals of biomolecules by more than a billion times. Using this approach, the system can sensitively distinguish protein fibrillation states (monomers versus fibrils), which have been difficult to measure with conventional diagnostic techniques.

The joint research team analyzed saliva samples from a total of 44 patients with epilepsy, schizophrenia, and Parkinson's disease, as well as 23 healthy controls, in collaboration with St. Vincent's Hospital. The results confirmed that the technology can classify these disorders with high accuracy, exceeding 90%, reaching up to 98%.

In particular, the ability to distinguish neurological disorders based on fundamental pathological indicators-namely, structural changes in proteins rather than total protein concentration-is regarded as a rare and significant achievement on a global scale.

An era has begun in which brain disease conditions can be assessed through simple saliva analysis without the need for costly PET imaging or cerebrospinal fluid testing."

Dr. Sung-Gyu Park, Study Principal Researcher, Korean Institute of Materials Science 

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As the work has been published in a top-tier international journal, the originality and innovation of the technology have now been formally recognized worldwide. Prof. Ho Sang Jung of Korea University added, "Given its non-invasive and low-cost nature, the technology holds significant potential for expansion beyond hospital outpatient settings to include home-based diagnostic devices."

The research team plans to pursue commercialization by developing portable Raman sensor–based point-of-care diagnostic devices and by promoting technology transfer to medical and life-science companies.

Source:

National Research Council of Science & Technology

Journal reference:

Al Ja'farawy, M. S., et al. (2026). Label-Free SERS Fingerprinting of Neuroprotein Conformational Dynamics in Human Saliva. Advanced Materials. DOI: 10.1002/adma.202513500. https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202513500.

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