Deans' stroke musings: Prospective analysis of long-term trajectories of functional scores before and after a diagnosis of stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, June 22, 2026

Prospective analysis of long-term trajectories of functional scores before and after a diagnosis of stroke

Nothing here gets survivors recovered; SO COMPLETELY FUCKING USELESS!

Prospective analysis of long-term trajectories of functional scores before and after a diagnosis of stroke

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We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

Abstract

Background

Limited data exist on long-term trajectories of functional scores before and after stroke diagnosis.

Methods

We analyzed 1325, 754, 3907, and 2902 incident strokes from China Health and Retirement Longitudinal Study (CHARLS), English Longitudinal Study of Ageing (ELSA), Health and Retirement Study (HRS), and Survey of Health, Ageing and Retirement in Europe (SHARE), respectively. Two non-stroke participants were matched to each stroke case by age and gender. Linear mixed models estimated trajectories of functional scores over time in individuals with and without stroke.

Results

Here we show that individuals with stroke have fewer memory but more depressive symptoms than those without stroke in most years from stroke onset with the largest difference several years after stroke onset. A steeper decline in memory is found among stroke patients for several years before and after stroke onset (adjusted β (95% CI) for annual change in CHARLS: −0.062 (−0.074, −0.049), ELSA: −0.024 (−0.03, −0.018), HRS: −0.026 (−0.03, −0.023)). Stroke participants have greater limitations in activities of daily living (ADL) than non-stroke participants, starting several years before stroke onset, with the difference increasing for five years after stroke onset. After that, the difference remains stable or decreases. Similar results are seen in instrumental ADL and the frailty index. Women have greater increases in CESD, mobility limitations, and frailty index compared with men.

Conclusions

Our analysis of data from multiple countries identifies the period when related functional scores show the greatest change, highlighting a critical window for stroke prevention and management.