Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, June 26, 2021

Inflammation and Stroke Risk: A New Target for Prevention

 Since we are not given a public location where this info is located you are completely reliant on your doctor having access to this, reading it, creating a protocol on it, and prescribing that protocol to you. DO YOU TRUST YOUR DOCTOR TO DO THOSE SIMPLE TASKS?

Inflammation and Stroke Risk: A New Target for Prevention

Originally publishedhttps://doi.org/10.1161/STROKEAHA.121.034388Stroke. ;0:STROKEAHA.121.034388

New therapeutic approaches are required for secondary prevention of residual vascular risk after stroke. Diverse sources of evidence support a causal role for inflammation in the pathogenesis of stroke. Randomized controlled trials of anti-inflammatory agents have reported benefit for secondary prevention in patients with coronary disease. We review the data from observational studies supporting a role for inflammation in pathogenesis of stroke, overview randomized controlled trials of anti-inflammatory therapy in cardiac disease and discuss the potential implications for stroke prevention therapy.

 

Protocol of a randomized controlled trial investigating the effectiveness of Recovery-focused Community support to Avoid readmissions and improve Participation after Stroke (ReCAPS)

I see nothing here that suggests that your doctors have a protocol for their tasks to prevent readmissions. That is totally evading their responsibility to get you 100% recovered.

Protocol of a randomized controlled trial investigating the effectiveness of Recovery-focused Community support to Avoid readmissions and improve Participation after Stroke (ReCAPS) 

First Published June 14, 2021 Product Review Find in PubMed 

To address unmet needs, electronic messages to support person-centered goal attainment and secondary prevention may avoid hospital presentations/readmissions after stroke, but evidence is limited.

Compared to control participants, there will be a 10% lower proportion of intervention participants who represent to hospital (emergency/admission) within 90 days of randomization.

Multicenter, double-blind, randomized controlled trial with intention-to-treat analysis. The intervention group receives 12 weeks of personalized, goal-centered, and administrative electronic messages, while the control group only receive administrative messages. The trial includes a process evaluation, assessment of treatment fidelity, and an economic evaluation. Participants: Confirmed stroke (modified Rankin Score: 0-4), aged ≥18 years with internet/mobile phone access, discharged directly home from hospital. Randomization: 1:1 computer-generated, stratified by age and baseline disability. Outcomes assessments: Collected at 90 days and 12 months following randomization.

Primary outcomes include hospital emergency presentations/admissions within 90 days of randomization. Secondary outcomes include goal attainment, self-efficacy, mood, unmet needs, disability, quality-of-life, recurrent stroke/cardiovascular events/deaths at 90 days and 12 months, and death and cost-effectiveness at 12 months. Sample size: To test our primary hypothesis, we estimated a sample size of 890 participants (445 per group) with 80% power and two-tailed significance threshold of α = 0.05. Given uncertainty for the effect size of this novel intervention, the sample size will be adaptively re-estimated when outcomes for n = 668 are obtained, with maximum sample capped at 1100.

We will provide new evidence on the potential effectiveness, implementation, and cost-effectiveness of a tailored eHealth intervention for survivors of stroke.

 

Risk of Fractures in Stroke Patients Treated With a Selective Serotonin Reuptake Inhibitor

Just in case your doctor did not get the memo that SSRIs originally thought to help rehab do not really help. Good thing I was only on these for a couple of months because I fell a lot on my left hip in order to strengthen it and prevent breaking my hip when I really get old. Don't listen to me, I'm not medically trained.

A while ago SSRIs were considered helpful in recovery.

Common antidepressant can help stroke patients improve movement and coordination Sept. 2015 

 

Antidepressants may help people recover from stroke even if they are not depressed Jan. 2013

  

 Have your doctor explain why  this discrepancy occurred between the upper two and this lower one.

 Then further research disproved that. 

 

Is there a suitable drug for stroke recovery?

The latest here:

Risk of Fractures in Stroke Patients Treated With a Selective Serotonin Reuptake Inhibitor

A Systematic Review and Meta-Analysis
Originally publishedhttps://doi.org/10.1161/STROKEAHA.120.032973Stroke. ;0:STROKEAHA.120.032973

Background and Purpose:

Stroke survivors have an increased risk of depression and bone fractures. Selective serotonin reuptake inhibitors (SSRIs) have been associated with an increased risk of fractures in observational studies. Several randomized controlled trials (RCTs) reporting the effect of SSRIs on the risk of fractures in stroke survivors have been published recently but have not been subject to a meta-analysis. We aimed to determine the risk of fractures associated with the use of SSRIs, and the risk of falls, seizures, and recurrent strokes as possible mediators of fractures, in stroke survivors.

Methods:

We conducted a systematic review and meta-analysis of RCTs of SSRIs in stroke survivors according to a protocol registered in PROSPERO (CRD42020192632). Web of Science, EMBASE, PsycINFO, and Ovid Medline/PubMed bibliographic databases, clinical trial registers, and grey literature sources were searched. RCTs of SSRIs versus placebo or no intervention that report the risk of fractures in adult survivors of hemorrhagic or ischemic stroke were included. Two reviewers independently screened search results and extracted data. Meta-analyses were conducted for each outcome using the Mantel-Haenszel random-effects models.

Results:

The searches yielded 683 records, of which 4 RCTs of 6 months duration with a total of 6549 participants were included in the meta-analysis: 3 studies of fluoxetine and 1 study of citalopram. Treatment with an SSRI for 6 months increased the risk of fractures with a risk ratio of 2.36 (95% CI, 1.64–3.39) compared with placebo. The risk of falls, seizures, and recurrent stroke was not statistically significantly increased. Only studies of fluoxetine and citalopram were available for inclusion in the review, and hence the generalizability of the findings to other SSRIs is uncertain.

Conclusions:

Based on available RCTs of fluoxetine and citalopram, SSRIs used for 6 months doubled the risk of fractures in stroke survivors.(So unless your doctors and therapists have a perfect fall prevention protocol you probably don't want this.)

Registration:

URL: https://www.crd.york.ac.uk/prospero/; Unique identifier: CRD42020192632.

 

Friday, June 25, 2021

A New Definition of Poststroke Spasticity and the Interference of Spasticity With Motor Recovery From Acute to Chronic Stages

Defining spasticity does nothing to get survivors recovered. 100% motor recovery is what survivors want, but you're not going to get under current guidelines.

A New Definition of Poststroke Spasticity and the Interference of Spasticity With Motor Recovery From Acute to Chronic Stages

First Published May 12, 2021 Research Article Find in PubMed 

The relationship of poststroke spasticity and motor recovery can be confusing. “True” motor recovery refers to return of motor behaviors to prestroke state with the same end-effectors and temporo-spatial pattern. This requires neural recovery and repair, and presumably occurs mainly in the acute and subacute stages. However, according to the International Classification of Functioning, Disability and Health, motor recovery after stroke is also defined as “improvement in performance of functional tasks,(Your tyranny of low expectations is baked into the stroke medical world, don't expect it to get better until survivors are in charge.) i.e., functional recovery, which is mainly mediated by compensatory mechanisms. Therefore, stroke survivors can execute motor tasks in spite of disordered motor control and the presence of spasticity. Spasticity interferes with execution of normal motor behaviors (“true” motor recovery), throughout the evolution of stroke from acute to chronic stages. Spasticity reduction does not affect functional recovery in the acute and subacute stages; however, appropriate management of spasticity could lead to improvement of motor function, that is, functional recovery, during the chronic stage of stroke. We assert that spasticity results from upregulation of medial cortico-reticulo-spinal pathways that are disinhibited due to damage of the motor cortex or corticobulbar pathways. Spasticity emerges as a manifestation of maladaptive plasticity in the early stages of recovery and can persist into the chronic stage. It coexists and shares similar pathophysiological processes with related motor impairments, such as abnormal force control, muscle coactivation and motor synergies, and diffuse interlimb muscle activation. Accordingly, we propose a new definition of spasticity to better account for its pathophysiology and the complex nuances of different definitions of motor recovery.

 


Cognitive Recovery After Stroke: A Meta-analysis and Metaregression of Intervention and Cohort Studies

Possible IS NOT GOOD ENOUGH! But I guess you'll just have to accept

your  5 lost years of brain cognition, since your doctor will know nothing concrete to get you recovered.

Or maybe you want to look in here, but you can't, I'm not medically trained.

Cognitive Recovery After Stroke: A Meta-analysis and Metaregression of Intervention and Cohort Studies

First Published May 22, 2021 Review Article Find in PubMed 

Cognition affects poststroke recovery, but meta-analyses of cognition have not yet provided a comparison of observational and intervention evidence.

To describe the trajectory of poststroke cognition and the factors that moderate it across intervention and observational cohorts.

Six databases were searched up to January 2020. Studies describing quantitative changes in cognition in adults poststroke were included. Interventions were classified into pharmacological, therapist-led, nonroutine/alternative, and usual care. Summary estimates were compared via hierarchical mixed-effects models. Age, recovery stage, stroke etiology, cognitive domain targeted in studies, and intervention types were investigated as moderators of cognition. Recovery stage and intervention were further analyzed in a multiplicative metaregression model.

A total of 43 intervention trials and 79 observation cohorts involving 28 222 stroke participants were included. Heterogeneity was significant (τ2 = 0.09; CI = 0.01-0.21, P < .001) with no evidence of publication bias. Cognitive recovery was greater in intervention trials (g = 0.47; CI = 0.37-0.58) than observational cohorts (g = 0.28; CI = 0.20-0.36) across all moderators analyzed. Nonroutine/alternative and pharmacological trials achieved the best overall results (g = 0.57, CI = 0.42-0.73, and g = 0.52, CI = 0.30-0.74, respectively), followed by therapist-led (g = 0.46; CI = 0.17-0.74), and usual care (g = 0.28; CI = 0.11-0.45) interventions. Medium recovery effects (ie, g ≥ 0.5) were observed in examining first-ever stroke, executive function, visuo-perceptual, consciousness, and psychomotor skills, 61 to 180 days poststroke, in participants aged 65 to 70 years.

Cognitive recovery is possible using different controlled interventions in all recovery stages, with smaller benefits ≥2 years poststroke. Longer-term studies are needed to determine the role of nonroutine/alternative therapies and the association between cognitive recovery and performance in everyday activities.

 

Curcumin Can Activate the Nrf2/HO-1 Signaling Pathway and Scavenge Free Radicals in Spinal Cord Injury Treatment

 Will this do the same for stroke? WHOM do we ask to do the followup? Specific names only. With NO LEADERSHIP AND NO STRATEGY NOTHING WILL BE DONE. Nothing on dosage or delivery method so you can't even guess how to accomplish this. Don't do this until 50 years from now when your doctor will have a prescription ready.

Curcumin Can Activate the Nrf2/HO-1 Signaling Pathway and Scavenge Free Radicals in Spinal Cord Injury Treatment

First Published May 13, 2021 Review Article Find in PubMed 

Spinal cord injury (SCI) is a devastating event that often leads to permanent neurological deficits. Evidence from emerging studies has implicated oxygen-derived free radicals and high-energy oxidants as mediators of secondary SCI. Therefore, targeting these mediators using antioxidants could be beneficial for the disease. Several signaling pathways, such as the nuclear factor erythroid-2-related factor 2/heme oxygenase 1 (Nrf2/HO-1), have been associated with the regulation of some pathophysiological features of SCI. Curcumin is a plant medicinal agent whose diverse pharmacological properties have been extensively investigated and reported, notably its ability to curtail inflammatory damage by inhibiting the nuclear factor-κ-light-chain-enhancer of activated B cells. In this review, we analyze the role of curcumin in activating Nrf2/HO-1 and scavenging free radicals to repair SCI. With its minimal side effects, curcumin could be a potential therapy for SCI treatment.

 

The Effect of Split-Belt Treadmill Interventions on Step Length Asymmetry in Individuals Poststroke: A Systematic Review With Meta-Analysis

Why are we doing a review on this when it has been out for years? We need protocols, WILL YOU JUST STARTING WRITING PROTOCOLS, instead of this lazy crapola of reviews. Reviews do nothing for survivors.  

The Effect of Split-Belt Treadmill Interventions on Step Length Asymmetry in Individuals Poststroke: A Systematic Review With Meta-Analysis

First Published May 12, 2021 Review Article Find in PubMed 

Individuals poststroke experience gait asymmetries that result in decreased community ambulation and a lower quality of life. A variety of studies have utilized split-belt treadmill training to investigate its effect on gait asymmetry, but many employ various methodologies that report differing results.

The purpose of this meta-analysis was to determine the effects of split-belt treadmill walking on step length symmetry in individuals poststroke both during and following training.

A comprehensive search of PubMed/MEDLINE, CINAHL, Web of Science, and Scopus was conducted to find peer-reviewed journal articles that included individuals poststroke that participated in a split-belt treadmill walking intervention. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) was used to assess risk of bias. Pooled Hedge’s g with random effects models were used to estimate the effect of split-belt training on step length symmetry.

Twenty-one studies were assessed and included in the systematic review with 11 of them included in the meta-analysis. Included studies had an average STROBE score of 16.2 ± 2.5. The pooled effects for step length asymmetry from baseline to late adaptation were not significant (g = 0.060, P = .701). Large, significant effects were found at posttraining after a single session (g = 1.04, P < .01), posttraining after multiple sessions (g = −0.70, P = .01), and follow-up (g = −0.718, P = .023).

Results indicate split-belt treadmill training with the shorter step length on the fast belt has the potential to improve step length symmetry in individuals poststroke when long-term training is implemented, but randomized controlled trials are needed to confirm the efficacy of split-belt treadmill training.

 

Clinical value of assessing motor performance in postacute stroke patients

 Assessments are totally fucking worthless without stroke protocols behind them to correct disabilities. ARE YOU THAT FUCKING STUPID? I once asked a replacement OT to be able to read a newspaper, you know with both hands holding the paper in front of you. She immediately redefined the goal to what she could accomplish, putting Dycem on a table to hold the paper in place as pages are turned. That is why 'professionals' should not be allowed in goal setting, goals will be dumbed down.

Clinical value of assessing motor performance in postacute stroke patients

 

Abstract

Background

Rehabilitative treatment plans after stroke are based on clinical examinations of functional capacity and patient-reported outcomes. Objective information about daily life performance is usually not available, but it may improve therapy personalization.

Objective

To show that sensor-derived information about daily life performance is clinically valuable for counseling and the planning of rehabilitation programs for individual stroke patients who live at home. Performance information is clinically valuable if it can be used as a decision aid for the therapeutic management or counseling of individual patients.

Methods

This was an observational, cross-sectional case series including 15 ambulatory stroke patients. Motor performance in daily life was assessed with body-worn inertial sensors attached to the wrists, shanks and trunk that estimated basic physical activity and various measures of walking and arm activity in daily life. Stroke severity, motor function and activity, and degree of independence were quantified clinically by standard assessments and patient-reported outcomes. Motor performance was recorded for an average of 5.03 ± 1.1 h on the same day as the clinical assessment. The clinical value of performance information is explored in a narrative style by considering individual patient performance and capacity information.

Results

The patients were aged 59.9 ± 9.8 years (mean ± SD), were 6.5 ± 7.2 years post stroke, and had a National Institutes of Health Stroke Score of 4.0 ± 2.6. Capacity and performance measures showed high variability. There were substantial discrepancies between performance and capacity measures in some patients.

Conclusions

This case series shows that information about motor performance in daily life can be valuable for tailoring rehabilitative therapy plans and counseling according to the needs of individual stroke patients. Although the short recording time (average of 5.03 h) limited the scope of the conclusions, this study highlights the usefulness of objective measures of daily life performance for the planning of rehabilitative therapies. Further research is required to investigate whether information about performance in daily life leads to improved rehabilitative therapy results.

Introduction

When a rehabilitation physician meets with a postacute stroke patient for counseling and rehabilitation program planning, decisions are usually based on two types of information: the results of a clinical examination of functional capacity (i.e., what a person can do in a standardized, controlled environment) and the patient’s subjective report on limitations and problems in daily life. With this information, the rehabilitation professional and the patient set specific goals together(The professional should never be involved in goal setting, they will dumb down the goals to make themselves not look bad.), with the objective of improving functional performance (i.e., what a person does in his daily life)(Oh my God, you are immediately forcing your tyranny of low expectations on your patients.100% recovery  is the only goal in stroke.) [1]. An objective measurement of functional performance was not available for a long time, but with the development of wearable sensors, it is now increasingly used in rehabilitation. Wearable sensor technology allows the collection of data that had previously been missing: the ‘objective measurement of clinically important naturalistic behaviors' [2]. Ideally, information about performance would be available for the planning and monitoring of a rehabilitation program and would include several aspects, such as overall physical activity, walking behavior and upper-limb use.

Studies involving wearable sensors generally report low physical activity levels, low walking performance and little use of the affected arm in daily life in stroke patients at the population level [3, 4]. However, the variability of daily life performance measures among patients was considerable in most studies [5, 6]. Demographic or stroke-related variables did not [7] or only partially [6, 8,9,10] explain the performance variability.

Potential applications of sensor-derived performance measures in rehabilitation programs have been described by many authors [11, 12], but we are not aware of any studies that examined the value of such performance information in individual patients receiving clinical rehabilitation. Additionally, with few exceptions [13, 14], most studies that employed wearable sensors to measure daily life performance in stroke patients focused on either upper or lower limbs. However, the clinical situation of a patient initiating a rehabilitation program would, in most cases, require a comprehensive assessment of upper-limb activity, walking behavior and physical activity.

We hypothesize that comprehensive, sensor-derived performance information is clinically valuable for the planning of rehabilitation programs for individual stroke patients who live at home. Performance data are deemed clinically valuable if they can be used as decision aids for therapeutic management or for counseling in individual patients [15]. We explore the clinical value in a narrative style, with a focus on individual patient performance and capacity data.

Daily life performance was recorded with a series of wearable sensors placed on the upper and lower extremities and the trunk. The wearable sensors were placed on the patient in the clinic by a clinical scientist as suggested by others [16] because the handling and placement of the wearable sensors was judged too complicated to be done independently by the stroke patients. Recordings were initiated during a routine medical consultation in the morning and lasted until late afternoon of the same day. We intended to measure performance under a scenario that is feasible in routine clinical practice. Therefore, repeatedly visiting patients over several days to help with sensor handling (e.g., for undoing/redoing or charging of sensor modules) was not an option, considering the time and cost constraints in most healthcare systems. On these grounds, a longer recording period was not an option.

Thursday, June 24, 2021

Improving Prehospital Stroke Diagnosis Using Natural Language Processing of Paramedic Reports

 Would you compare them to these faster objective diagnosis options.  Get human opinions out of it.

Maybe you want these much faster objective diagnosis options.

Hats off to Helmet of Hope - stroke diagnosis in 30 seconds; February 2017

 

Microwave Imaging for Brain Stroke Detection and Monitoring using High Performance Computing in 94 seconds March 2017

 

New Device Quickly Assesses Brain Bleeding in Head Injuries - 5-10 minutes April 2017

Ski-Mask Design AIR Coil Offers Whole-Brain Imaging Without Claustrophobia

The latest here:

 


Improving Prehospital Stroke Diagnosis Using Natural Language Processing of Paramedic Reports

Originally publishedhttps://doi.org/10.1161/STROKEAHA.120.033580Stroke. ;0:STROKEAHA.120.033580

Background and Purpose:

Accurate prehospital diagnosis of stroke by emergency medical services (EMS) can increase treatments rates, mitigate disability, and reduce stroke deaths. We aimed to develop a model that utilizes natural language processing of EMS reports and machine learning to improve prehospital stroke identification.

Methods:

We conducted a retrospective study of patients transported by the Chicago EMS to 17 regional primary and comprehensive stroke centers. Patients who were suspected of stroke by the EMS or had hospital-diagnosed stroke were included in our cohort. Text within EMS reports were converted to unigram features, which were given as input to a support-vector machine classifier that was trained on 70% of the cohort and tested on the remaining 30%. Outcomes included final diagnosis of stroke versus nonstroke, large vessel occlusion, severe stroke (National Institutes of Health Stroke Scale score >5), and comprehensive stroke center-eligible stroke (large vessel occlusion or hemorrhagic stroke).

Results:

Of 965 patients, 580 (60%) had confirmed acute stroke. In a test set of 289 patients, the text-based model predicted stroke nominally better than models based on the Cincinnati Prehospital Stroke Scale (c-statistic: 0.73 versus 0.67, P=0.165) and was superior to the 3-Item Stroke Scale (c-statistic: 0.73 versus 0.53, P<0.001) scores. Improvements in discrimination were also observed for the other outcomes.

Conclusions:

We derived a model that utilizes clinical text from paramedic reports to identify stroke. Our results require validation but have the potential of improving prehospital routing protocols.

 

Repeated Mechanical Endovascular Thrombectomy for Recurrent Large Vessel Occlusion: A Multicenter Experience

You better hope your doctor has reconciled the two opposite conclusions here and previously. Or don't your doctors even know of these two pieces of research?

Here: Repeat MT seems to be safe and effective for attaining vessel recanalization.(This only seems to consider recanalization, not what is important to survivors.)

 

Previous:

More than one clot retrieval attempt after stroke causes decline in functional outcomes

Repeated attempts to retrieve a clot in patients with acute stroke increased both the rate of emboli to new territory and infarct growth volume, with an impact on functional outcomes even when recanalization was successful.

 

The latest here:

Repeated Mechanical Endovascular Thrombectomy for Recurrent Large Vessel Occlusion: A Multicenter Experience

Originally publishedhttps://doi.org/10.1161/STROKEAHA.120.033393Stroke. 2021;52:1967–1973

Abstract

Background and Purpose:

Mechanical thrombectomy (MT) is now the standard of care for large vessel occlusion (LVO) stroke. However, little is known about the frequency and outcomes of repeat MT (rMT) for patients with recurrent LVO.

Methods:

This is a retrospective multicenter cohort of patients who underwent rMT at 6 tertiary institutions in the United States between March 2016 and March 2020. Procedural, imaging, and outcome data were evaluated. Outcome at discharge was evaluated using the modified Rankin Scale.

Results:

Of 3059 patients treated with MT during the study period, 56 (1.8%) underwent at least 1 rMT. Fifty-four (96%) patients were analyzed; median age was 64 years. The median time interval between index MT and rMT was 2 days; 35 of 54 patients (65%) experienced recurrent LVO during the index hospitalization. The mechanism of stroke was cardioembolism in 30 patients (56%), intracranial atherosclerosis in 4 patients (7%), extracranial atherosclerosis in 2 patients (4%), and other causes in 18 patients (33%). A final TICI recanalization score of 2b or 3 was achieved in all 54 patients during index MT (100%) and in 51 of 54 patients (94%) during rMT. Thirty-two of 54 patients (59%) experienced recurrent LVO of a previously treated artery, mostly the pretreated left MCA (23 patients, 73%). Fifty of the 54 patients (93%) had a documented discharge modified Rankin Scale after rMT: 15 (30%) had minimal or no disability (modified Rankin Scale score ≤2), 25 (50%) had moderate to severe disability (modified Rankin Scale score 3–5), and 10 (20%) died.

Conclusions:

Almost 2% of patients treated with MT experience recurrent LVO, usually of a previously treated artery during the same hospitalization. Repeat MT seems to be safe and effective for attaining vessel recanalization, and good outcome can be expected in 30% of patients.(Is your good outcome

100% recovery? If not, then you didn't get a good outcome.)

 

Trunk Impairment as a Predictor of Activities of Daily Living in Acute Stroke

Predictions are worthless, survivors want to know what protocols there are to get 100% recovered. NOT THIS PREDICTION CRAPOLA.

Trunk Impairment as a Predictor of Activities of Daily Living in Acute Stroke

Masahiro Ishiwatari1,2*, Kaoru Honaga1, Akira Tanuma1, Tomokazu Takakura1, Kozo Hatori1, Akihiro Kurosu1 and Toshiyuki Fujiwara1,3
  • 1Department of Rehabilitation Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
  • 2Department of Rehabilitation, Kiminomori Rehabilitation Hospital, Chiba, Japan
  • 3Department of Physical Therapy, Juntendo University Faculty of Health Science, Tokyo, Japan

Background and purpose: Trunk function plays a key role in performing activities of daily living (ADL) including locomotion and sitting. Sitting and ADL should be performed as early as possible especially during the acute phase of stroke rehabilitation. Therefore, this study aimed to assess trunk function among patients with acute stroke using the Trunk Impairment Scale (TIS) and to predict its functional outcomes.

Methods: Overall, 67 patients with acute stroke (i.e., within 2 days of occurrence of the stroke) were included. The following clinical assessment items were obtained within 48 h after stroke onset and on the day before discharge from the hospital. Trunk function was examined using TIS and Trunk Control Test (TCT). The motor function of the upper and lower extremities was assessed using the stroke impairment assessment set motor (SIAS-M) score, and ADL was assessed using functional independence measure motor (FIM-M) items.

Results: Multiple regression analysis was performed using the stepwise regression method, using the total FIM-M score following discharge as the dependent variable and age, TIS, TCT, SIAS-M, and FIM-M within 48 h after stroke onset as the independent variables. Age, TIS, and FIM-M within 48 h after stroke onset were selected as the input variables and showed a high-adjusted determination coefficient (R2 = 0.79; P < 0.001).

Conclusion: TIS is a reliable method for evaluating trunk control function and is an early predictor of ADL among patients with acute stroke.

Introduction

Trunk function is frequently impaired after stroke, affecting balance, gait, and activities of daily living (ADL) (1, 2). In stroke rehabilitation, trunk control is a fundamental motor skill that is essential for performing many functional tasks (3). In fact, the function of the trunk is not just ensuring the balance when sitting but also providing the ability to stabilize the proximal part of the body, allowing the movement of the distal part and selectively initiating trunk movements (4). There are several studies in the literature that investigated muscle strength in the extremities after stroke (57). There are also studies that have assessed the trunk muscle strength as the ability to control balance, trunk movement, and trunk muscle strength in the sitting and standing positions (1, 812). Verheyden et al. emphasize the importance of trunk performance, particularly that related to the static sitting balance, when predicting functional outcome after stroke (13). In the stroke rehabilitation process, the trunk function is an important predictor of the functional outcome (1, 8, 14). Therefore, the trunk function plays a key role in basic activities, such as sitting, transferring from the supine to the sitting position, and also rolling.

In acute stroke rehabilitation, it is important to prevent the decline of physical activity and to improve ADL. Acquisition of sitting ability and trunk performance are necessary to improve physical activity and ADL (2, 15). Fujiwara et al. developed the seven-item Trunk Impairment Scale (TIS) to assess trunk dysfunction in patients with stroke (3). Validity and reliability have already been examined. The TIS developed by Verheyden et al. was shown to be effective in predicting the functional outcome of subacute stroke (13). According to the Agency for Health Care Policy and Research guidelines, turning, sitting, and other activities should be started within 24–48 h after stroke onset, if medically possible (16). The group that started rehabilitation within 72 h of admission had a shorter length of stay and better walking status at discharge than the group that started rehabilitation >72 h after the admission (2). Although the mortality rate remained the same, the functional outcome tended to be better when patients increased the amount of training in the acute phase by starting sitting and standing rehabilitation within 24 h of the onset of illness (17).

van Nes et al. in their study of balance using individually adjustable chairs placed on a force platform considered 5–6 weeks after the onset as the subacute phase (18). Franchignoni et al. rather focused on patients with subacute stroke, with an average of 46 days between stroke onset and admission for rehabilitation (14). Other studies in the literature have included patients 1–2 weeks after stroke onset (19, 20) and patients who were transferred to a rehabilitation hospital 1–3 months after stroke onset, and these patients were able to maintain a sitting position (4, 9, 13, 18, 21). For the former reasons, we have classified the acute phase as within 2 weeks and the subacute phase as within 1–3 months after stroke onset. In our study, assessing trunk function with TIS within 48 h after stroke onset helped us assess the level of functional impairment in patients with stroke at the bedside in the acute phase, even if the patients were unable to safely maintain a seated position.

The most frequently identified variables predicting ADL after stroke include age and initial severity of motor and functional deficits (22). Trunk performance has also been identified as an important independent predictor of ADL after stroke (3, 9, 13, 22, 23). Fujiwara et al. conducted a multiple regression analysis to predict the Functional Independence Measure (FIM) motor score at discharge and confirmed that adding TIS as one of the predictors improved the explanation of variation in the FIM motor score at discharge from 66 to 75%, which can contribute to the prediction of functional status after stroke (3). Verheyden et al. examined the predictive validity of TIS and its subscales in predicting the Barthel Index score at 6 months after stroke onset in a multicenter study; the best predictors of the Barthel Index score were the TIS total score and the static sitting balance subscale score at admission (13). Collin and Wade (1) developed the Trunk Control Test (TCT) to assess the trunk function in patients with stroke. Franchignoni et al. (14) reported that using the TCT score at admission as one of the predictors better explains the FIM score at discharge than the FIM score at admission alone. The addition of trunk function assessment to ADL at discharge allowed the determination of a strong prognostic value. The clinical tools to assess the trunk performance include TCT (1, 14, 23), the trunk control items of the Postural Assessment Scale for Stroke (PASS) (9), TIS developed by Fujiwara et al. TIS (3), and TIS developed by Verheyden et al. (24). To better understand the recovery of the trunk function after stroke and to develop more effective treatment programs for patients with trunk imbalances, the trunk function needs to be assessed at the level of ability impairment and functional impairment.

A safe and less time-consuming evaluation method is desirable for patients with acute stroke. To the authors' knowledge, no previous study has reported the assessment of the trunk function and its prognosis within 48 h. Therefore, the purpose of this study was to investigate the prognosis prediction of patients with acute stroke using TIS for the assessment of the body trunk function.