Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, January 16, 2026

Nitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures

Your competent? doctor has an EXACT PROTOCOL ON THIS and knows about the Nobel prize awarded for the work finding this? NO? 

 Nitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures 

Caetana M.Carvalho,1 and Inês M.Araújo2,3 Coimbra, Portugal Center for Neuroscience and Cell Biology, Neuroendocrinology and Neurogenesis Group, University of Coimbra,- Regenerative Medicine Program, Department of Biomedical Sciences and Medicine, University of Algarve, Center for Biomedical Research (CBMR), University of Algarve, Correspondence should be addressed to Inˆes M. Ara´ujo; imaraujo@ualg.pt Received April ; Accepted Academic Editor: Renata Santos Copyright © May Bruno P. Carreira et al.-- Faro, Portugal Faro, Portugal is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 

Hippocampal neurogenesis is changed by brain injury. When neuroin ammation accompanies injury, activation of resident microglial cells promotes the release of in ammatory cytokines and reactive oxygen/nitrogen species like nitric oxide (NO). In these conditions, NO promotes proliferation of neural stem cells (NSC) in the hippocampus. However, little is known about the role of NO in the survival and di erentiation of newborn cells in the injured dentate gyrus. Here we investigated the role of NO following seizures in the regulation of proliferation, migration, di erentiation, and survival of NSC in the hippocampus using the kainic acid (KA)inducedseizuremousemodel.WeshowthatNOincreasedtheproliferationofNSCandthenumberofneuroblasts following seizures but was detrimental to the survival of newborn neurons. NO was also required for the maintenance of long-term neuroin ammation. Taken together, our data show that NO positively contributes to the initial stages of neurogenesis following seizures but compromises survival of newborn neurons
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