3D-printed biomimetic scaffolds integrated with exosomes from injury-preconditioned hUCMSCs promote brain tissue repair via neuroprotection and neurogenesis

 

Do you really think anyone in stroke is competent enough to get stroke testing going? I don't, everything in stroke IS A COMPLETE FUCKING FAILURE! Prove me wrong; failure is defined as not getting to 100% recovery! Don't try your tyranny of low expectations on me. Here; oc1dean@gmail.com, I'll print it verbatim with my reply. Have at it, or are you afraid to engage with a stroke-addled survivor?

Of course your competent? doctor can inform these researchers of earlier protocols they already created on these.

• scaffolds (28 posts to December 2011)
• exosomes (67 posts to March 2011)

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The latest here:

3D-printed biomimetic scaffolds integrated with exosomes from injury-preconditioned hUCMSCs promote brain tissue repair via neuroprotection and neurogenesis

An Zhu;

Xiao-Yin Liu;

Siyi Li;

Yun Hao;

Pan Wei;

jingjing wang;

Xiaoyu Wang

Publisher: The Royal Society of Chemistry

Received: 21 May 2026

Accepted: 06 August 2026

First published: 07 August 2026

Online ISSN: 2050-7518

Print ISSN: 2050-750X

© 2026 The Author(s). Published by the Royal Society of Chemistry

The combined function of 3D-printed collagen/silk fibroin (3D-CS) scaffolds with injury-preconditioned exosomes obtained from human umbilical cord mesenchymal stem cells (hUCMSCs) in traumatic brain injury repair remains unclear. Here, we demonstrate that exosomes produced from hUCMSCs preconditioned with brain trauma extracts have a neuroprotective effect on a craniocerebral trauma model in beagles. Notably, injury-preconditioned exosomes generated by hUCMSCs combined with 3D-CS scaffolds markedly promoted neuroregeneration and angiogenesis after TBI. Injury-preconditioned exosomes combined with 3D-CS scaffolds also alleviated both the proinflammatory factor-induced apoptosis and nerve apoptosis induced by injury in vivo. We further showed that the joint action of injury-preconditioned exosomes combined with 3D-C/S scaffold-induced neurorepair ultimately promoted the recovery of neurological dysfunction after traumatic brain injury. In summary, this study reveals the cofunction of injury-preconditioned exosomes and 3D-CS scaffolds in response to traumatic brain injury and suggests a potential therapeutic strategy.

Visual Abstract

The combined function of 3D-printed collagen/silk fibroin (3D-CS) scaffolds with injury-preconditioned exosomes obtained from human umbilical cord mesenchymal stem cells (hUCMSCs) in traumatic brain injury repair remains unclear. Here, we...

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