You doctor and researcher needs to inform you if this condition is a problem for you as a bleeder stroke. And what they are doing to correct it.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0051245
Abstract
Background
Endothelial
cell junctions control blood vessel permeability. Altered permeability
can be associated with vascular fragility that leads to vessel weakness
and haemorrhage formation.
In vivo studies on the function of
genes involved in the maintenance of vascular integrity are essential to
better understand the molecular basis of diseases linked to
permeability defects. Ve-ptp (Vascular Endothelial-Protein Tyrosine
Phosphatase) is a transmembrane protein present at endothelial adherens
junctions (AJs).
Methodology/Principal Findings
We
investigated the role of Ve-ptp in AJ maturation/stability and in the
modulation of endothelial permeability using zebrafish (
Danio rerio). Whole-mount
in situ hybridizations revealed z
ve-ptp expression exclusively in the developing vascular system. Generation of altered z
ve-ptp
transcripts, induced separately by two different splicing morpholinos,
resulted in permeability defects closely linked to vascular wall
fragility. The ultrastructural analysis revealed a statistically
significant reduction of junction complexes and the presence of immature
AJs in z
ve-ptp morphants but not in control embryos.
Conclusions/Significance
Here we show the first
in vivo
evidence of a potentially critical role played by Ve-ptp in AJ
maturation, an important event for permeability modulation and for the
development of a functional vascular system.
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