Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, December 6, 2025

Effects of Serotonergic Psychedelics on Synaptic Function and Neuroplasticity

 Your competent? doctor already has EXACT PROTOCOLS for these already, right! Oh no, nothing exists because your doctor and hospital ARE COMPLETELY FUCKING INCOMPETENT!

In my opinion I expect my doctor, therapists and hospital to be completely up-to-date on all research that gets survivors recovered! That is competence defined properly!

  • DMT (8 posts to November 2020)

  • LSD (5 posts to September 2018)

  • magic mushrooms (10 posts to October 2014) 

Effects of Serotonergic Psychedelics on Synaptic Function and Neuroplasticity

Abstract INTRODUCTION: Serotonergic psychedelics such as LSD, psilocin, and DMT have shown significant potential for the treatment of neuropsychiatric disorders including depression, addiction, and anxiety accompanying life-threatening illnesses. Although the effects of these substances on neuronal activity and neuroplasticity have been demonstrated, a deeper understanding of their mechanisms of action is essential for the development of new treatments. 
OBJECTIVES: The main objective of this study was to determine the effects of the serotonergic psychedelics LSD, psilocin, and DMT on neurotransmitter release and their influence on the activity of neuronal networks. The study also addressed possible mechanisms involved in this modulation. METHODS: To monitor the effects of psychedelics on key presynaptic mechanisms, we used genetically encoded sensors that allow for the monitoring of synaptic vesicle fusion, synaptopHluorin, glutamate release, iGluSnFR, and presynaptic calcium levels, synGCaMP6, expressed in primary rat cortical cultures. A pharmacological approach using agonists and antagonists of these receptors was used to study the effects of individual types of 5-HT receptors. Immunofluorescence staining and western blotting were used to assess the levels and phosphorylation states of several key regulators of presynaptic functions and neuroplasticity. To assess the acute effects...

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