Didn't your competent? doctor show you this video on how plaque forms and why cholesterol is not the problem?; INFLAMMATION IS! NO! So you DON'T have a functioning stroke doctor, do you? Why hasn't s/he been fired yet?
4 min. 36 seconds of explanation. This is what happened to my right carotid artery. My doctor should have explained this but no, he didn't say anything.
The accent is a bit hard to understand and needs to be rerecorded to a laypersons understanding.
New research explores the earliest stages of coronary plaque inflammation
A Cedars-Sinai Health Sciences University-led study has identified molecular changes that appear to trigger atherosclerosis years before inflammation, sharing their findings in European Heart Journal.[1]
The group believes this could a key discovery in the development of next-generation early prevention therapies.
The study's authors found previously unrecognized molecular pathways and a possible master regulator protein called MLXIPL that could become future targets for clinicians working to stop plaque from ever developing.
“We analyzed proteins and gene activity in coronary artery tissue from young adults who died of trauma and had no known coronary artery disease, and we found that more than half already had preclinical atherosclerosis,” first author Sarah Parker, PhD, an associate professor of cardiology and biomedical sciences and co-director of the proteomics and metabolomics core at Cedars-Sinai Health Sciences University, said in a statement. “This suggests that changes in cellular metabolism and communication begin before the inflammation long considered a hallmark of the disease.”
Parker said this research provides a direct picture of what is happening inside the artery wall and may explain why some people are more vulnerable to heart disease than others.There have been studies showing very early atheroma lesions appearing in the first decade of life. Even with that in mind, however, questions have remained.
"What we haven’t understood is what causes those early changes to progress into dangerous plaques that lead to heart attacks," Parker explained. "In studying coronary artery tissue before people ever developed symptoms, we were able to capture some of the earliest molecular changes that appear to set the disease in motion."
She said a big surprise from this research is that there are cellular metabolism and communication changes before the development of the classic inflammatory signals usually associated with atherosclerosis. There has been a lot of research focused on addressing inflammation to prevent heart disease, but this takes things even further and may offer help identify new preventive therapies.
"What our study suggests is that important molecular changes begin much earlier," Parker said. "If we want to prevent plaque from forming, we need to understand those earliest changes—not just what happens after inflammation has already taken hold."
She explained that proteins can tell researchers how the body’s cells are responding to risk factors like cholesterol, blood pressure or smoking. The differences in protiens found in people's cells can help explain why people with identical cholesterol levels will result in one never having coronary disease, while the other develops plaques.
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