TNF is the target of etanercept and Dr. Edward Tobinicks methods. So if Dr. Tobinick is right there should have been some presentation here on use of etanercept for stroke. Dr. Tobinick is not one of the speakers or committee members. If fixing TNF really helps stroke survivors someone at this conference would know. A great stroke association would find out the answer. But we have jackshit instead and no one will do the work to find out the answer. Because we have NO f*cking strategy on how to solve any of the problems in stroke.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=153778&CultureCode=en
On May 20-23, 2015 the “15th International TNF Conference” was
organized with great enthusiasm at the Handelsbeurs venue by Prof. Dr.
Peter Vandenabeele (Inflammation Research Center, VIB and Ghent
University) and Prof. Henning Walczak (UCL Cancer Institute London).
More than 230 persons from over 25 countries actively vividly
participated in the presentations and discussions. The congress
consisted of 53 talks by internationally selected speakers and two
highly attended poster sessions with 100 communications.
Among the speakers renowned persons like Prof. Dr. David Baltimore
(Californian Institute of Technology, in 1975 one of the youngest Nobel
prize winners ever and discoverer of the reverse transcriptase), Prof.
Dr. Shigekazu Nagata (Osaka University, president of the Japanese
Biochemical Society, who discovered several fundamental biochemical
mechanisms of apoptosis and phagocytosis of apoptotic cells) and Dr.
Vishva Dixit (Vice-president Genentech, San Francisco, world expert in
molecular mechanisms of inflammation) were present during the whole
meeting.
The conference started with a tribute and thanksgiving
to Prof. Em. Dr. Walter Fiers from Ghent University by short speeches
nicely decorated with pieces of Mozart, Schubert and Verdi performed by
the Morandi Quartet. Prof. Em. Dr. Walter Fiers performed leading
research on the domain of cloning and recombinant expression of
cytokines among which Tumor Necrosis Factor (TNF), a protein that is
produced in our body during infection, cancer and cellular stress. TNF
also plays a crucial role during inflammatory diseases and is therefore
therapeutically blocked by administration of neutralizing antibodies
during Crohn’s disease, rheumatoid arthritis and heavy cases of
psoriasis.
One of the important subjects of the conference were the insights in
the molecular mechanisms how TNF and TNF family members elicit a wide
diversity of cellular processes such cell survival, inflammation,
differentiation and cell death (apoptosis or necroptosis), and these
various “decisions” are taken. The last years the research on the
identification of these molecular decision points has revealed that the
activity of RIP kinases is crucial in these. Several pharmaceutical
companies are now running discovery programs to develop new drugs that
block these important class of kinases.
The conference was closed by a nocturne in the Museum of Fine Arts
where in a speech on the restauration of the Ghent Altarpiece science
and arts were marvelously unified. The scientific quality, the venue
location, the fairy-like atmosphere of the historical center of Ghent,
and last but not least, the organizational skills of Veronique
Vandevoorde before and during the meeting were highly appreciated.
http://www.tnf2015.org/
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