Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, September 12, 2018

Roles of Nicotine in the Development of Intracranial Aneurysm Rupture

You'll have to ask your doctor if the problem is the nicotine or the many thousands of unknown sustances in cigarettes.  Because I'm going to get nicotine patches for my next stroke. Don't follow me, I'm not medically trained in stroke. Is your doctor? What proof does your doctor show you of the results they provide on recovering from stroke? Just listening to my doctor talk about my stroke it was incredibly obvious he knew absolutely nothing about stroke recovery.

34 posts on nicotine which your doctor will know zilch about. Time for you to train your doctor again. I'm going to do the nicotine patches for my next stroke even though I have no clue on dosage.

Roles of Nicotine in the Development of Intracranial Aneurysm Rupture

Originally published10 Sep 2018Stroke. 2018;0:STROKEAHA.118.021706

Abstract

Background and Purpose—

Tobacco cigarette smoking is considered to be a strong risk factor for intracranial aneurysmal rupture. Nicotine is a major biologically active constituent of tobacco products. Nicotine’s interactions with vascular cell nicotinic acetylcholine receptors containing α7 subunits (α7*-nAChR) are thought to promote local inflammation and sustained angiogenesis. In this study, using a mouse intracranial aneurysm model, we assessed potential contributions of nicotine exposure and activation of α7*-nAChR to the development of aneurysmal rupture.

Methods—

Intracranial aneurysms were induced by a combination of deoxycorticosterone-salt induced hypertension and a single-dose elastase injection into cerebrospinal fluid in mice.

Results—

Exposure to nicotine or an α7*-nAChR–selective agonist significantly increased aneurysm rupture rate. Coexposure to an α7*-nAChR antagonist abolished nicotine’s deleterious effect. In addition, nicotine’s promotion of aneurysm rupture was absent in smooth muscle cell–specific α7*-nAChR subunit knockout mice but not in mice lacking α7*-nAChR on endothelial cells or macrophages. Nicotine treatment increased the mRNA levels of vascular endothelial growth factor, platelet-derived growth factor-B, and inflammatory cytokines. α7*-nAChR antagonist reversed nicotine-induced upregulation of these growth factors and cytokines.

Conclusions—

Our findings indicate that nicotine exposure promotes aneurysmal rupture through actions on vascular smooth muscle cell α7*-nAChR.
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