Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, April 21, 2026

Gut-brain axis targeting postbiotics for treatment of psychological and neurodegenerative disorders

 

There is massive amounts of research on this already! What's needed IS EXACT PROTOCOLS TO GET SURVIVORS RECOVERED! And you are too blitheringly stupid to see what needs to be done!

Gut-brain axis targeting postbiotics for treatment of psychological and neurodegenerative disorders


https://doi.org/10.1016/j.fbio.2026.108950Get rights and content
Under a Creative Commons license
Open access

Highlights

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    Postbiotics offer a therapeutic option as an adjuvant or alternative therapy.
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    Stringent manufacturing, handling and storage requirements plaguing probiotics are circumvented by postbiotics.
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    Postbiotics can alter neurogenetics and trigger meaningful changes to psychological and neurodegenerative pathways.
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    Stress hormonal responses are altered by postbiotics, mitigating pathogenesis of anxiety and depression.

Abstract

Current pharmacological treatments for psychological and neurodegenerative disorders largely ignore the vital role of the gut microbiome in cognition. Antipsychotics and antidepressants often disturb the gut environment, impacting mood stabilisation, neurotransmitter signalling, and cognitive functions mediated by the gut-brain axis. This ultimately undermines treatment efficacy while triggering cascading metabolic side effects, including weight gain and hyperglycaemia. Coupled with the rising global burden of these disorders, there is a need for innovative therapies that effectively target the gut microbiome to pharmacologically mediate the gut-brain axis. Postbiotics, comprising inert microorganisms or their components, are one such microbiome-targeted therapy that has recently shown the capacity to treat an array of psychological and neurodegenerative disorders, including depression, anxiety, Alzheimer's, and Parkinson's disease, while mitigating common manufacturing, storage, and efficacy limitations of conventional probiotics. However, clinical trials validating postbiotic treatment efficacy in neurological diseases are lacking, indicating the need for further investigation. This review therefore aims to examine the therapeutic potential of postbiotics and bridge the gap between preclinical research and clinical practice.
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