Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, August 14, 2026

Intensive blood pressure-lowering cut recurrent stroke risk by around 38% after brain haemorrhage

 

Your doctor obviously hasn't though through blood pressure at all. Lowering too much means the penumbra will die quicker because of lack of oxygenated blood. Can your competent? doctor think at all about how to get you recovered?

Intensive blood pressure-lowering cut recurrent stroke risk by around 38% after brain haemorrhage

Intensive, long-term blood pressure-lowering treatment reduced the risk of recurrent stroke by 38%, without increasing serious adverse events(Is not recovering a serious adverse event because you allowed vastly more neurons to die, due to lack of blood and oxygen?), in people who have survived an intracerebral haemorrhage (ICH). The findings of the major meta-analysis were published today in The Lancet Neurology.

Researchers analysed data from four randomised controlled trials involving 2,944 adults with ICH. Two studies investigated fixed-dose antihypertensive therapies and two evaluated treatment strategies based on defined blood pressure targets.

During a follow-up period of up to six years, recurrent stroke of any type occurred in 6.5% of patients receiving intensive blood pressure-lowering compared with 10.4% of those receiving less intensive treatment or standard care (the control arm). This translated to a 38% reduction in recurrent stroke risk, with consistent benefits observed across all studies.

Professor Craig Anderson, senior author and Senior Professorial Fellow at The George Institute said the findings provide compelling evidence for more intensive blood pressure management after ICH.

“Intracerebral haemorrhage is one of the deadliest forms of stroke, with limited treatment options and a high risk of recurrence among survivors. Our analysis shows that intensive blood pressure treatment can prevent 16 recurrent strokes for every 1,000 patients treated within the first year alone. These findings reinforce the central role of blood pressure control in secondary stroke prevention.”

During follow-up, average systolic blood pressure (SBP) was 127 mm Hg in the intensive treatment group and 138 mm Hg in the control group, representing a mean difference of 11.2 mm Hg.

The reduction in recurrent stroke was mainly driven by an approximately 61% lower risk of ICH among patients receiving intensive treatment. Importantly, there was no observed increase in serious adverse events, which occurred in approximately 29% of patients in the intensive treatment group and 33% of patients receiving standard care.

The findings have important global implications. More than three million people experience ICH each year and there’s an estimated 17 million survivors.2 Among these survivors, approximately one quarter will later die from recurrent stroke or cardiovascular disease.3

The ICH burden falls disproportionately on low- and middle-income countries, where high blood pressure is often inadequately controlled.4 Rates of ICH are almost twice as high in these countries compared with high-income nations.4

Subgroup analysis showed that the benefits of intensive blood pressure lowering were consistent regardless of how much time had passed since the initial ICH event.

Effects were consistent across different baseline blood pressure levels. Notably, patients whose baseline blood pressure was already at conventional target remained at considerable risk and benefitted from blood pressure lowering. For example, among those with systolic blood pressure ≤130 mm Hg at baseline, recurrent stroke occurred in 13.9% of control patients compared with 6.2% of patients receiving intensive treatment.

Professor Anderson added that the findings challenge assumptions made by current guidelines.

“Generally, guidelines recommend treatment to a target of less than 130/80 mm Hg, but our study showed that patients at or below this threshold can still face a significant risk of recurrent stroke.”

“Preventing stroke recurrence requires us to address the persistent barriers to blood pressure control, such as poor treatment adherence and therapeutic inertia. To achieve reliable control, we need to continue pursuing approaches that have shown promise, including fixed-dose combination therapies and structured treatment titration protocols.”

The TRIDENT study, led by The George Institute for Global Health, was the only trial in this analysis that exclusively enrolled patients with spontaneous ICH. The remaining trials included people with either ischaemic stroke or ICH at baseline.

No comments:

Post a Comment