Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, November 8, 2022

VR-based rehabilitation of cognitive functions among stroke-survivors

You do realize that if you want to motivate survivors to do their rehab you give  them EXACT REHAB PROTOCOLS LEADING TO 100% RECOVERY?  That alone is enough motivation to get them going. Guidelines are useless for that motivation.

 VR-based rehabilitation of cognitive functions among stroke-survivors


Severin A. Eliassen1, Harald Soleim1, Atle B. Geitung1 and Lars Peder V. Bovim2,3
1Faculty of Engineering, Western Norway University of Applied Sciences
2SimArena Rehabilitation Lab, Department of Health and Functioning, Western Norway University of Applied Sciences,
Bergen, Norway
3The Vitality Centre for Children and Youth, Haukeland University Hospital, Bergen, Norway

Abstract

Stroke is one of the most common causes of long-term disability, with the risk of decreased cognitive
functioning, resulting in a significant need for rehabilitation modalities. For modalities to be effective,
there is an increasing focus on making them motivating and individualized. This study implements and tests two immersive Virtual Reality (VR) based games aimed at cognitive rehabilitation. The Box Painting Game and The Plane Game were developed in iterations with health professionals. The games are customizable for the therapist by using a computer or a tablet application. The usability and usefulness of the proposed solution were evaluated via the system usability scale (SUS) and semi-structured interviews in two iterations. These included four health professionals. Evaluations show that the games’ usability is acceptable and has the potential to increase the engagement and motivation of stroke survivors.
Keywords
Virtual reality, Cognitive functions, Stroke, Rehabilitation, Interventions, Serious games.
1. Introduction
In 2019, stroke was the second most common cause of death and the third most common cause of disability-adjusted life years globally [ 1 , 2 ] and in Norway [2 ]. As healthcare is constantly evolving and new studies have been conducted, death rates have decreased [ 3 ]. This leads to an increasing number of patients who need extensive rehabilitation. The goal of rehabilitation is to give the affected as much independence as possible(WRONG!  The goal is 100% recovery!) and be able to go back to work and enjoy the hobbies they love.Keeping the motivation of the patient high is one of today’s problems during traditional rehabilitation, as the patients can often perceive the exercises as monotone and repetitive [ 4]. Another challenge with stroke is the significant difference in impairments for each patient [ 5, 6]. The project aims to tackle these problems by developing two fully immersive VR games with adjustable difficulty to supplement traditional rehabilitation. However, the work presented is limited to evaluations with physical therapists at this stage. This limitation is to first see the acceptability and usability of the games as a supplement. The therapists are a good starting point in assessing the usefulness. They are also the entry point of taking the games into the rehabilitation process and recruiting patients to a clinical trial. Then, after achieving a satisfying result, patients can be involved to check the motivational and engagement gains and the effectiveness of the proposed games. In a related project by Førde hospital trust [ 7 ], Beat Saber 1 is being used to supplement the rehabilitation of sitting and standing balance among stroke survivors. They observe with Beat Saber that patients have increased motivation and engagement in the treatment, in accordance with [ 9 ]. Technology-assisted rehabilitation is not a new concept but rather an emerging field. Tobler-Ammann et al. [ 10 ] designed nine exergames for rehabilitation of visuospatial neglect after stroke. The games were Virtual Reality (VR) experiences developed for use on a computer monitor and with the Novint Falcon haptic controller. This is a 3D touch controller with force feedback [ 11 ]. They used the technology acceptance model, group interviews with the therapists, and individual interviews with the patients to evaluate the games. The study found that the therapist was more skeptical about using these games than the patients. Patients perceived the games as a motivating and nice change from regular rehabilitation. However, they could become repetitive, and some had trouble seeing their relevance to real life at first or at all. Both groups of users were not convinced to use exergames after the trial period, as the patients preferred to use their time on other activities after being discharged. Faria et al. [ 12] compare traditional paper-pencil cognitive training methods with adaptive training in VR. The article uses Reh@City v2.0 [ 13], a VR game that simulates eight daily life activities. The game is experienced through a computer monitor, where interactions happen through a motion-tracking camera. These activities are spread across eight different locations in a city, including a bank, a store, and a post office. For the evaluation, they recruited 35 outpatients who had an ischemic stroke 2 at least six months prior to the study (18 in the pen-paper group and 17 in VR). Their findings do not show a significant performance difference between the paper-pencil intervention and VR, but VR users experienced more intensive training, leading to more repetitions and challenging tasks. The authors concluded that it could lead to more cognitive improvements, but further research with a larger sample size and other rehabilitation tasks is necessary. Gamito et al. [ 15 ] designed a Virtual Reality cognitive training application. The VR application included a scenario that consisted of several daily life activities for training cognitive functions such as working memory, visuospatial orientation, selective attention, recognition memory, and digit retention. They recruited 20 stroke patients, where 10 used the VR application and 10 were in the control group. Overall their results indicate benefits in memory and attention but no significant results in visual memory. The presented articles are not an exhaustive list of related works. There exists a wide range of projects and studies on rehabilitation using VR, both fully immersive and not, such as [9, 16, 17, 18, 19, 20, 21]. As is evident from the presented related work, gamification of the rehabilitation process is not a new trade, and quite a bit of novel work is done, both in terms of cognitive and physical rehabilitation of stroke survivors. However, the use of fully immersive VR for cognitive stroke rehabilitation is rather understudied, as a lot of the related work is done through screen-based VR [ 10 ], [ 12 ], [ 17 ], and some require specialized tools and controllers [10 ], [ 12 ]. In addition, there is work that uses keyboard and mouse interaction instead of fully utilizing the potential of head-mounted displays (HMD) [20].

Virtual reality and serious game therapy for post-stroke individuals: A preliminary study with humanized rehabilitation approach protocol humanized rehabilitation approach

 If you want to humanize your stroke therapy you'll create 100% recovery protocols.  Since you're not even attempting 100% recovery, you're just wasting time and money.

Virtual reality and serious game therapy for post-stroke individuals: A preliminary study with humanized rehabilitation approach protocol humanized rehabilitation approach


Camille MarquesAlvesafAndressa RastreloRezendeaLuanne CardosoMendesefThiago Sá dePaivaaGabriel FernandesCyrinobJúlia Tannús deSouzabMarco Aurélio MaiaSilvacLuciane Aparecida Pascucci Sande deSouzadEduardo Lázaro MartinsNavesa
https://doi.org/10.1016/j.ctcp.2022.101681Get rights and content

Abstract

Objective

The current study proposed the development and preliminary validation of a humanized training approach for upper limb rehabilitation of chronic post-stroke individuals, using serious game (SG) and virtual reality (VR) technologies.

Materials and methods

Ten individuals with chronic stroke participated in the study. Accompanied by a health professional, 15 sessions of the SG were performed in a laboratory, in a humanized way, lasting between 30 and 45 min each. The assessments were made pre- and post-intervention with the SG, and the following parameters were evaluated (considering the elbow joint): Modified Ashworth Scale (MAS), range of movement (ROM) and tonic stretch reflex threshold (TSRT). Global measures such as quality of life (QOL) were also assessed by the Stroke-Specific Quality of Life Scale (SSQL), Brunnstrom Recovery Scale (BRS) and General Health Questionnaire (GHQ-28). The following tests were applied to verify statistically significant differences: Shapiro-Wilk test, t-test, and Wilcoxon-Mann-Whitney test.

Results

The parameters ROM, TSRT, BRS, and SSQL showed statistically significant differences between pre- and post-intervention (p < 0.01). The ROM increase was about 8%. The objective evaluation of spasticity (provided by the TRST) showed an increase of 28% over the average pre- and post-intervention values. Three participants showed decreased resistance to passive stretching according to the results of the MAS, and seven participants moved to the next stage of the BRS. For QOL, the scores indicated around 20% of post-intervention improvement.

Conclusion

The intervention had no adverse effects, showed a high degree of compliance, provided increased ROM, improved QOL, reduced spasticity and allowed these individuals the opportunity to test a promising technology for upper limb rehabilitation with emphasis in humanized aspects of therapy.

Introduction

Approximately 16 million individuals worldwide are victims to stroke every year, making this condition one of the leading causes of mortality and disability [1]. It is estimated that 80% of people affected by stroke do not regain proper arm function even six months after the event [2,3]. This condition limits or prohibits the performance of several activities of daily living, such as eating, getting dressed, taking care of personal hygiene, among others, negatively impacting the quality of life [4].

Several studies have reported the difficulty of rehabilitating the motor function of the upper limbs (UL), especially for those individuals in chronic phase. For those individuals, spontaneous neuroplasticity has almost disappeared, leading to the necessity of constant rehabilitation activities with adequate intensity and volume of practice, variety, specificity, motivation and biofeedback [5]. Due to the monotony of traditional methods and slow improvement in patients' conditions, some of these individuals end up stopping the rehabilitation process altogether or are discharged from treatment in hospitals and rehabilitation clinics when the therapeutic possibilities are exhausted and the chances of functional recovery are diminished [2,6].

In this context, the implementation of technologies such as serious games (SG) and virtual reality (VR) provide an alternative strategy for the treatment of UL of people with chronic post-stroke conditions. Studies have shown that therapy using such technologies can contribute significantly in maintaining quality of life (QOL) and enable neurological rehabilitation in these individuals. These methods also provide greater engagement and efficiency in rehabilitation treatments [7,8], with proven clinical benefits [9].

In order to propose more efficient ways of interaction with SG and VR, researchers have been trying to underline important characteristics that contribute to the increase of engagement of individuals in therapy, increasing the chances of success of the rehabilitation program [10]. A humanized approach can reduce the barriers to seek help and reduce the suffering of the patient and his family from the first contact with the team [11]. However, the focus of each of those studies is generally restricted to aspects related to the construction and development of the SG such as visuals, music and goals 11. The implementation of technological devices and the automation of healthcare services can bring an aspect of dehumanization to the relationship between the health professional and the patient, making it extremely necessary to propose a humanized approach, in which the health professional is able to make the patient feel truly well and welcome [12].

No studies were found that focused on evaluating whether the presence, support and adoption of a humanized treatment for the health professional towards patients positively influenced the clinical outcomes of a SG and VR therapy. Therefore, this study proposed a preliminary humanized approach protocol of application and interaction with the SG, incorporating actions by which the humanization of care can be understood and applied, aimed at individuals with chronic post-stroke. In addiction, the health professional was not only an adjuvant during the therapy sessions, but rather actively participated in creating a hospitable environment for the participants and provided social support through positive feedback and instructions on how to use the game. Motor aspects and global measures were registered in order to verify the impact of this intervention on the UL, and consequently in the QOL of chronic post-stroke individuals.


AI-driven Stroke Rehabilitation Systems and Assessment: A Systematic Review.

Since only 10% of survivors get to full recovery, there is NO therapy department in the world that is effective. That is how stroke survivors rate effectiveness, they don't use the tyranny of low expectations to declare success. Stroke survivors have only 1 question to answer: Am I 100% recovered? Y/N? If yes, you may have an effective stroke department.

What Is the Evidence for Physical Therapy Poststroke? A Systematic Review and Meta-Analysis

The evidence is appalling that stroke therapy only gets 10% to full recovery. THAT BY ANY DEFINITION IS COMPLETE AND TOTAL FAILURE! Only by using the tyranny of low expectations can  the stroke medical world  claim any modicum of success. I'd fire everyone involved in stroke for not even attempting to get to 100% recovery. All this biomarkers and predicting failure to recover is totally fucking useless to get survivors recovered.

YOU need to get involved, you can't leave this up to stroke medical 'professionals', they came up with the inadequate Helsingborg declarations.


Helsingborg 1996

Helsingborg 2006

What Is the Evidence for Physical Therapy Poststroke? A Systematic Review and Meta-Analysis



 
What Is the Evidence for Physical Therapy Poststroke? ASystematic Review and Meta-Analysis
Janne Marieke Veerbeek
1
, Erwin van Wegen
1
, Roland van Peppen
2
, Philip Jan van der Wees
3
,Erik Hendriks
4
, Marc Rietberg
1
, Gert Kwakkel
1,5
*
1
Department of Rehabilitation Medicine, MOVE Research Institute Amsterdam, VU University Medical Center, Amsterdam, The Netherlands,
 2
Department of Physiotherapy, University of Applied Sciences Utrecht, Utrecht, The Netherlands,
 3
Scientific Institute for Quality of Healthcare (IQ healthcare), Radboud UniversityNijmegen Medical Center, Nijmegen, The Netherlands,
 4
Department of Epidemiology, Maastricht University, Maastricht, The Netherlands,
 5
Department of Neurorehabilitation, Reade Center for Rehabilitation and Rheumatology, Amsterdam, The Netherlands

Abstract

Background:
 
Physical therapy (PT) is one of the key disciplines in interdisciplinary stroke rehabilitation. The aim of thissystematic review was to provide an update of the evidence for stroke rehabilitation interventions in the domain of PT.
Methods and Findings:
 
 Randomized controlled trials (RCTs) regarding PT in stroke rehabilitation were retrieved through asystematic search. Outcomes were classified according to the ICF. RCTs with a low risk of bias were quantitatively analyzed.Differences between phases poststroke were explored in subgroup analyses. A best evidence synthesis was performed forneurological treatment approaches. The search yielded 467 RCTs (N=25373; median PEDro score 6 [IQR 5–7]), identifying 53interventions. No adverse events were reported. Strong evidence was found for significant positive effects of 13interventions related to gait, 11 interventions related to arm-hand activities, 1 intervention for ADL, and 3 interventions forphysical fitness. Summary Effect Sizes (SESs) ranged from 0.17 (95%CI 0.03–0.70; I2=0%) for therapeutic positioning of theparetic arm to 2.47 (95%CI 0.84–4.11; I2=77%) for training of sitting balance. There is strong evidence that a higher dose of practice is better, with SESs ranging from 0.21 (95%CI 0.02–0.39; I2=6%) for motor function of the paretic arm to 0.61(95%CI 0.41–0.82; I2=41%) for muscle strength of the paretic leg. Subgroup analyses yielded significant differences withrespect to timing poststroke for 10 interventions. Neurological treatment approaches to training of body functions andactivities showed equal or unfavorable effects when compared to other training interventions. Main limitations of thepresent review are not using individual patient data for meta-analyses and absence of correction for multiple testing.
Conclusions:
 
There is strong evidence for PT interventions favoring intensive high repetitive task-oriented and task-specific training in all phases post stroke. Effects are mostly restricted to the actually trained functions and activities. Suggestions for prioritizing PT stroke research are given.
Citation:
 Veerbeek JM, van Wegen E, van Peppen R, van der Wees PJ, Hendriks E, et al. (2014) What Is the Evidence for Physical Therapy Poststroke? A SystematicReview and Meta-Analysis. PLoS ONE 9(2): e87987. doi:10.1371/journal.pone.0087987
Editor:
 Terence J. Quinn, University of Glasgow, United Kingdom
Received
 October 29, 2013;
 Accepted
 December 30, 2013;
 Published
 February 4, 2014
Copyright:
 
 2014 Veerbeek et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding:
 This research project was supported by the Royal Dutch Society for Physical Therapy (KNGF grant no. 8091.1; http://www.fysionet.nl/). The funders hadno role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests:
 The authors have declared that no competing interests exist.* E-mail: g.kwakkel@vumc.nl

Introduction

Prospective studies have estimated that about 795.000 people in the USA suffer a first or recurrent stroke each year [1]. The prevalence of chronic stroke in the USA is estimated at about 7million [1], with about 80% of patients with stroke being over the age of 65. The prevalence of stroke is likely to increase in the future due to the aging population. Even though acute stroke care (Quit talking about 'care', just tell us recovery and results.)has improved, for example by large-scale application of recombinant tissue plasminogen activator (rTPA) [1,2] and organized interdisciplinary inpatient stroke care [3], and although mortality rates have been decreasing [1], a large number of patients still remain disabled regardless of the time that has elapsed post stroke.Only 12% of the patients with stroke are independent in basic activities of daily living (ADL) at the end of the first week [4]. In the long term, 25–74% of patients have to rely on human assistance for basic ADLs like feeding, self-care, and mobility [5].Interdisciplinary complex rehabilitation interventions [6,7] are assumed to represent the mainstay of post stroke care [8]. One of the key disciplines in interdisciplinary stroke rehabilitation is physical therapy which is primarily aimed at restoring and maintaining ADLs, usually starting within the first days and often continuing into the chronic phase post stroke [8]. While the interdisciplinary character of stroke rehabilitation is paramount,the availability of specific, up-to-date, and professional evidence-based guidelines for the physical therapy profession is crucial for making adequate evidence-based clinical decisions [9–11]. The recommendations in the first Dutch evidence-based ‘Clinical Practice Guideline for physical therapy in patients with stroke were based on meta-analyses of 123 randomized controlled trials(RCTs) and date back to 2004 [12]. In view of the tremendous growth in the number of RCTs in this field, it is now necessary to re-establish the ‘‘state of the art’’ concerning the evidence for physical therapy interventions in stroke rehabilitation. This aim is in line with the 2006 Helsingborg Declaration on European Stroke Strategies(Which I consider a total failure for not even trying for 100% recovery), which states that stroke rehabilitation should be based on evidence as much as possible [13,14]. The first aim of the present systematic review was to update our previous meta-analyses of complex stroke rehabilitation interventions in the domain of physical therapy, based on RCTs with a low risk of bias (i.e. a moderate to good methodological quality) with no restrictions to the comparator. Primary outcomes, measured post intervention, were defined at the levels of body functions and/or activities and participation of the International Classification of Functioning, disability and health model (ICF) [15]. The second aim was to explore whether the timing of interventions post stroke moderated the main effects.
 
More at link


Miracle Patient Makes Remarkable Recovery Two Years After Stroke, Dances on 73rd Birthday

Miracles should never have to occur in stroke recovery. My god, this is so fucking simple, just execute and deliver these steps.

1. EXACT damage diagnosis.

2. Leading to EXACT stroke recovery protocols.

3. Leading to survivors doing the EXACT rehab and number of reps.

4. Leading to 100% recovery.

5. NO MIRACLE REQUIRED!

Miracle Patient Makes Remarkable Recovery Two Years After Stroke, Dances on 73rd Birthday

Susan Klein is a 73-year-old miracle patient who is making amazing progress in rehab two years after her stroke. Thanks to the compassionate therapists at Atrium Health Musculoskeletal Institute and Atrium Health Carolinas Rehabilitation, and a strong support system at home, she's looking forward to walking again soon.

Most stroke patients don’t see much progress in their recovery after six months. By the one-year mark, they usually start to accept their health status as their “new normal.” 

Susan Klein, a 73-year-old grandmother and resident of Denver, North Carolina, has defied the odds by continuing to achieve goals in physical therapy over two years after her stroke. 

Susan had a stroke in July 2020. After completing some initial rehabilitation in spring 2021, she hit a plateau and wasn’t making progress. She continued to work on her mobility at home without much success. 

Sixteen months after her stroke, she was spending most of her days in her wheelchair, and she was unable to walk. Her husband, Russ Klein, and her full-time caregiver, Sharlene Burke, were concerned about her safety and that she was gradually losing more of her independence. They encouraged her to give physical therapy another try.

In November 2021, Susan started working with Heather Harrison, a physical therapist with Atrium Health Lincoln Rehabilitation Denver. This was the turning point when extraordinary changes began to happen.   

Within five to six weeks of the program, Susan was already making progress. As she started to achieve small milestones, her goals began to change. “Our initial goal was to get her up and out of her wheelchair without falling,” said Harrison. “But then we got her to walk longer distances and go up and down stairs – things I never thought would be possible.”

Now, more than two years after her stroke, Susan is still benefiting from therapy at Atrium Health Carolinas Rehabilitation. With a long history of treating neurological diagnoses, these physical therapy experts offer a stroke rehabilitation program that’s more specialized than what many other centers offer. In fact, Atrium HealthCarolinas Medical Center, Atrium Health Pineville,Atrium Health Cabarrus and Atrium Health Unionhave been recognized as the top 10% for nationwide stroke care by U.S. News & World Report.

Strategies that worked

To help Susan improve her mobility, Harrison and her physical therapy team used the following methods:

Find the right motivation. From the beginning, it was vital for Harrison to identify the type of feedback Susan responded to and what made her feel comfortable to try new activities. “We spent time getting to know Susan in order to figure out her goals and motivations,” said Harrison. “We tried giving lots of positive reinforcement and started noticing small achievements.  We then tried to relate how those small accomplishments were going to allow Susan to achieve her larger goals.” 

For example, Susan was having trouble standing in the shower. When Heather realized that Susan responds well to music, they worked on practicing standing for long periods of time in the clinic while listening to music in order to improve her standing balance and endurance. At home, Sharlene plays music while she’s in the shower, which has made it much easier for Susan to stand. 

Manage anxiety and fear. Susan was coping with severe depression and anxiety after her stroke. She had given up the hope of achieving what she perceived as a normal life. She had some spasticity (muscle stiffness) in one of her legs. She also didn’t have good motor control in her legs for walking. This made her very anxious to try new activities, since she was afraid of falling.

“It was important for us to remain positive but also acknowledge that trying new things is scary,” said Harrison. “We assured her that we would do our best to keep her safe, and this gradually built up her trust and confidence to push a little farther when trying stairs and walking longer distances.”

Sharlene appreciated how the therapists listened to Susan’s concerns if she was timid about trying something new. She explained, “They allowed her to gather her thoughts before doing any activities. And, of course, they helped her to the finish line.”

Set small, achievable goals.(NO, NO, NO! Do not let your therapist or doctor set your goals for you using the tyranny of low expectations! DEMAND THEY GET YOU 100% RECOVERED! I'd suggest suing them, that might get them to actually get them to do their jobs correctly.) As Harrison and Susan set small goals, they built on the success of any small achievements during physical therapy. For example, if Susan walked 30 feet during her session, Harrison would encourage her to take a couple more steps at the following session.  She was able to walk into the clinic from the parking lot on her very last day of therapy with her cane for the first time (approximately 200 feet).

“My nurses showed the utmost respect to the pace I needed to help manage my aches and pains,” said Susan. “The therapists explained everything to me prior to each exercise. Sometimes it took visual presentation, but they made sure I understood the task prior to execution.”

Relate functional skills to personal goals. As Susan began building her functional skills, Heather helped relate those skills to her personal goals. Once Susan could see how small activities were helping to achieve her goals at home, she became more motivated to keep trying new activities.

Try photo and video feedback. Sharlene took videos and pictures during Susan’s physical therapy sessions and replayed them at home. This allowed Susan to share her progress with her husband and continue to improve. “After a stroke, it’s important to learn how your new body moves with the neurological issue on one side,” said Harrison. “Susan is a very visual person, so it helped her to see herself as she moved and internalize that feedback.”

Make therapy fun. Heather used music and dancing to encourage Susan’s movements. This helped her have fun while she practiced balancing and shifting during physical therapy.

Goals achieved

An important goal for Susan was to dance on her 73rd birthday, which she achieved this past April. Heather played her favorite music during therapy to help her practice her dance moves. On her birthday, she was able to walk from the car to the restaurant and sit in a regular chair – something she hadn’t been able to do since her stroke.

Susan also achieved the goal of returning to sleeping in her own bed. She had been sleeping in a hospital bed since her stroke and was eager to return to a normal routine. Using a table at the clinic that could simulate the height of her bed, Susan practiced getting in and out of bed safely. 

Susan made a recent trip to a retail store and tried on clothes for the first time since her stroke. While trying them on, she was able to put into practice a side-stepping technique that Harrison taught her during therapy. “She was elated because she could see the functional application of her physical therapy, and it helped her reach another goal, Harrison noted.

Over the summer, Susan successfully walked down her back steps at home and got into her pool to swim. She achieved these goals with little assistance from her support team.

Susan chose Atrium Health’s physical therapy team because of their outstanding care and closeness to home. “The level of care throughout the entire process has been exceptional,” she explained. “I had caring, compassionate therapists who were sensitive to my needs. This brought about a fast healing process in a friendly environment.” 

Continued progress

Susan is happy to continue gaining new skills. “I welcome the fact that I’m that much closer to walking again,” she said. “Just recently, I was able to get up out of the recliner without assistance.” Her future goals include taking a boat ride with her family. 

Aside from physical therapy, Harrison attributes Susan’s continued progress to her dedication to achieving her goals and her ongoing support from Russ and Sharlene. 

“Watching Susan’s progress reminds me of why I chose this profession: to help people,” explained Harrison. “To see someone go from spending most of their time in a wheelchair to moving and enjoying life with their grandkids is so rewarding. Those are the small things we take for granted.”

What has made the biggest difference for Susan? “Confidence is key,” she said. “That and the experience of the therapists will make walking again possible. I recommend Atrium Health to anyone needing help like I did.”

Outpatient physical therapy works in partnership with Atrium Health Musculoskeletal Institute, providing expert rehabilitation care. 
 

Elevation of cardiac biomarkers in stroke is associated with pathological findings on cardiac MRI—results of the HEart and BRain interfaces in Acute Stroke study

Do you really think your doctor and hospital are going to see this and create a protocol to ENSURE such testing takes place?  And why wouldn't they be creating a protocol?

Laziness? Incompetence? Or just don't care? No leadership? No strategy? Not my job?

Elevation of cardiac biomarkers in stroke is associated with pathological findings on cardiac MRI—results of the HEart and BRain interfaces in Acute Stroke study

Abstract

Introduction:

Cardiac biomarkers, such as high-sensitivity cardiac troponin T (hs-cTnT), are frequently elevated in ischemic stroke patients but the mechanisms underlying this elevation are insufficiently understood. We determined the presence of cardiac damage, assessed using cardiac magnetic resonance imaging (CMR), in stroke patients with elevated hs-cTnT and brain natriuretic peptide (BNP).

Methods:

This is a post hoc analysis of the prospective, investigator-initiated, cross-sectional HEart and BRain interfaces in Acute Stroke (HEBRAS) study. All patients underwent the measurement of hs-cTnT and BNP as well as gadolinium-enhanced CMR in the acute phase of ischemic stroke. We performed unadjusted and adjusted logistic regression models to assess the association between hs-cTnT and BNP elevation and the presence of pathological CMR findings.

Results:

Two hundred and thirty-three stroke patients (median age 67 years, 33% female) were included, of whom 43 (21%) had elevated hs-cTnT and 109 (47%) had elevated BNP. Hundred of the 233 (43%) patients had pathological findings on CMR had focal fibrosis as detected by late-gadolinium enhancement (LGE) in 51 (23%), left-ventricular hypertrophy (LVH) in 38 (16%), reduced LVEF in 32 (14%), and left-atrial dilatation in 34 (15%). After adjustment for potential confounders, both hs-cTnT (adjOR 5.0 (95%CI 2.1–11.7), p < 0.001) and BNP (adjOR 4.1 (95%CI 2.3–7.3), p < 0.001) were significantly associated with pathological findings on CMR. Hs-cTnT was associated with LGE, LVEF, and LVH, whereas BNP was associated with left-atrial dilatation and LVEF, LVH.

Conclusion:

Elevated cardiac biomarkers in acute stroke including CMR are strongly associated with pathological findings on CMR. In acute stroke patients, the elevation of cardiac biomarkers may identify patients who require a more thorough cardiology work-up.

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Does implementation of a standardized pathway of stroke care affect functional outcome after stroke?

 WRONG GOAL!  survivors want a pathway to recovery, NOT 'CARE' Do you not understand what stroke survivors want?

Does implementation of a standardized pathway of stroke care affect functional outcome after stroke?

Abstract

Background:

A stroke care pathway (SCP) was introduced in Norway in 2018. The goal of the pathway was to avoid delay in treatment and diagnostics of acute stroke and to secure treatment according to national guidelines. In this study, we aimed to evaluate how the implementation of the SCP affects outcome after stroke.

Methods:

We performed a register-based study using data from the Norwegian Stroke Register that covers 87% of acute stroke patients in Norway. Patients included 1 year before and 1 year after the introduction of the care pathway were compared (2017 vs 2019). Change in functional outcome, the proportion of independent patients 90 days post-stroke, discharge destination, proportions admitted to stroke units and 90 days mortality were compared. Functional outcome was measured using modified Rankin Scale (mRS) and functional independence was defined as mRS 0–2.

Results:

In total, 11,009 patients with 90 days follow-up data were analyzed. Comparing the cohorts from 2017 and 2019, there was no change in demographics or stroke characteristics. No statistically significant differences in mRS, admission to thrombolysis time, or 90 days mortality were found. However, the proportion of patients discharged directly home and treated in a stroke unit increased from 2017 to 2019.

Conclusion:

The implementation of a standardized pathway of stroke care in Norway did not lead to improvement in functional outcome or a reduction in 90 days mortality. (Because you didn't set it up to deliver results! Just 'care'.)However, the proportion of patients discharged directly home increased, and more patients were treated in stroke units in 2019 compared with 2017.

Introduction

Clinical care pathways have been introduced in different healthcare settings for many years to organize and standardize care processes. They are primarily implemented to improve the quality and efficiency of evidence-based treatment and to improve patient safety and satisfaction. Their effect is hard to evaluate due to widely different settings, clinical heterogeneity, and the use of different outcome measures.14
The use of clinical care pathways in stroke treatment was initiated in the 1990s. More efficient and improved quality of stroke care and reduced variations in stroke treatment are listed as reasons for their implementation. Previous studies, including a Cochrane review from 2005 and a cluster randomized controlled trial study from Italy, show that the evidence of their effect on patient outcome is highly inconclusive.3,5,6
In 2017, the Norwegian health authorities decided to establish a national standardized pathway of stroke care based on national guidelines for stroke treatment and diagnostics.7,8 The aim of the stroke care pathway (SCP) was to ensure that patients with acute stroke would receive well organized and predictable care without non-medical delay in assessment, diagnostics, or treatment. In addition, the SCP intended to reduce variations in stroke care throughout the country. Previous reports from the Norwegian Stroke Register (NSR) and studies from other countries show differences in care based on geography, urban-rural localization, and demographics. The SCP was implemented in 2018.911
In the present study, we evaluate the period from suspicion of acute stroke to the patient is ready to be discharged from hospital. The pathway is organized in phases, and each phase has a recommended target time. The goal is to ensure compliance with the target times and to avoid delay in treatment of acute stroke. The SCP is centered on procedures with significant effect on stroke outcome such as reperfusion therapy and treatment in a stroke unit. As reperfusion therapy is highly time dependent and surgery of symptomatic carotid stenosis is recommended as early as possible and preferably within 2 weeks target times regarding these treatments are highlighted (see supplementary Table 1).1214
The aim of our study was to evaluate if the introduction of this SCP had an impact on functional outcomes and 90 days mortality after stroke. In addition, we aimed at comparing the proportion of patients admitted to a dedicated stroke unit and proportions discharged directly home in 2019 versus 2017.
Our primary hypothesis was that patients admitted to hospital with the diagnosis of acute stroke the year after the introduction of the pathway (2019) would have significantly better function compared with those admitted the year prior to the introduction (2017).
More at link.

Statin therapy ‘vastly superior’ to common dietary supplements for cholesterol lowering

Go ask your doctor what supplements you should be taking and where do you get pure forms.

Statin therapy ‘vastly superior’ to common dietary supplements for cholesterol lowering

CHICAGO — Daily rosuvastatin lowered LDL, total cholesterol and serum triglycerides significantly more than placebo and six common over-the-counter dietary supplements, with no supplement lowering LDL more than placebo, researchers reported.

“Many of us cardiologists and primary care physicians see our patients’ medication lists littered with a variety of over-the-counter dietary supplements,” Luke J. Laffin, MD, co-director of the Center for Blood Pressure Disorders at Cleveland Clinic, told Healio. “When we look at the data, three-quarters of Americans take some form of dietary supplement and, unfortunately, almost 20% of those are doing so for so-called ‘heart health’ or ‘cholesterol health.’ In that vein, we know there are not any peer-reviewed data to support claims made about these supplements.”

Statins_AdobeStock
Daily rosuvastatin lowered LDL, total cholesterol and serum triglycerides significantly more than placebo and six common over-the-counter dietary supplements, with no supplement lowering LDL more than placebo.
Source: Adobe Stock

For the SPORT study, presented at the American Heart Association Scientific Sessions, researchers randomly assigned participants 5 mg daily of rosuvastatin, placebo or one of six dietary supplements: fish oil (Nature Made), cinnamon (Nutriflair), garlic (Garlique), turmeric (Bioschwartz), plant sterols (Nature Made CholestOff Plus) or red yeast rice (Arazo Nutrition).

Comparing supplements vs. statin

The eight-arm, randomized, double-blind, investigator-initiated study included 190 adults aged 40 to 75 years who had LDL between 70 and 189 mg/dL, no history of atherosclerotic CVD and an increased 10-year risk of ASCVD (mean age, 64 years; 59% women; 89% white). Mean baseline LDL was 128.2 mg/dL, median high-sensitivity C-reactive protein was 1.4 mg/L, mean total cholesterol was 206.5 mg/dL and median serum triglycerides were 87.5 mg/dL.

Luke J. Laffin

“We chose those [inclusion] criteria because, in line with the current lipid guidelines, those people should at least have a discussion about a statin,” Laffin told Healio.

After randomization, the researchers measured fasting lipids, conducted a complete metabolic panel and assessed high-sensitivity C-reactive protein at baseline and day 28; adherence was measured using pill counts from returned bottles.

The primary endpoint was percent change in LDL from baseline for rosuvastatin compared in a hierarchical order with placebo and each supplement after 28 days.

The percent LDL reduction with rosuvastatin was greater than all supplements and placebo (P < .001). Mean percent decrease in LDL for rosuvastatin was –37.9% (95% CI –42.1 to –33.6). The difference in LDL reduction with rosuvastatin compared with placebo was –35.2% (95% CI, –41.3 to –29.1; P < .001). None of the dietary supplements demonstrated a significant decrease in LDL compared with placebo; however, garlic showed a significant increase in LDL of 7.8% (95% CI 1.7 to 13.8; P = .01), according to the results.

Patients randomized to the low-dose statin group had a 24.4% reduction in total cholesterol from baseline (95% CI, –27.6 to –21.3) compared with placebo and all supplements (P < .001 for all comparisons). The statin group also experienced significant serum triglyceride lowering from baseline (–19.3%, 95% CI –27.6 to –9.9), which was greater than all comparators (P < .001 for all comparisons), according to the results.

Adverse event rates were similar across study groups; there were no reports of musculoskeletal or neurological adverse events in the statin arm.

Supplement data ‘sobering’

“What we saw was not necessarily surprising,” Laffin told Healio. “Rosuvastatin lowered LDL by almost 38% and was vastly superior to any of the supplements and placebo. Additionally, supplements did not lower LDL cholesterol, inflammatory markers, total cholesterol or triglycerides any more than placebo. One of the surprising features was garlic actually increased cholesterol. This was sobering and I’m glad we have this data for the public.”

Laffin noted that SPORT was not a CV outcomes trial; the lack of an impact on inflammatory biomarkers with rosuvastatin was likely due to the small sample size. Additionally, the short study duration may not fully capture the impact of supplements on lipid and inflammatory biomarkers, he said.

“Just because a supplement may be marketed as ‘natural’ does not mean it is safe,” Laffin told Healio. “With these supplements, we do have to worry about drug-drug interactions. The way these are metabolized, they can interact with certain prescription drugs. We know that fish oil does not improve CV outcomes, but it may increase risk for atrial fibrillation. These supplements still come in pill form; they are not coming from a garden.”

References:

Perspective

Back to Top Martha Gulati, MD, MS, FACC, FAHA, FASPC, FESC)

Martha Gulati, MD, MS, FACC, FAHA, FASPC

As we all know, sometimes our patients have more trust in supplements vs. prescription medications. It is important to be able to communicate with our patients when supplements are advertised on their label as protecting the heart or lowering cholesterol. This study found a very small dose of rosuvastatin lowered LDL and total cholesterol effectively, whereas none of the other supplements did. Sometimes people think physicians have been somehow “bought” by pharmaceutical companies. Statins are generic drugs; there is nothing to gain by prescribing them. People need to understand that prescription medications are well studied. What has not been well studied to date is supplements. Supplements are not safe just because they are sold over the counter; they are not regulated. If I can say an alternative is available that can do something, I will guide a patient appropriately. We want to know if something our patients are taking is safe and effective. The reality is these kinds of trials are not that common, so this is a very practical trial. It is a good start.

Martha Gulati, MD, MS, FACC, FAHA, FASPC
Professor of Medicine
Smidt Heart Institute at Cedars-Sinai
Director of CVD Prevention and Associate Director
Barbra Streisand Women's Heart Center
President, American Society of Preventive Cardiology
Disclosures: Gulati reports no relevant financial disclosures.

Perspective

Back to Top Amit Khera, MD, MSc, FACC, FAHA, FASPC)

Amit Khera, MD, MSc, FACC, FAHA, FASPC

It is one thing if a person chooses to take a supplement on their own; it is another if they are taking these supplements in lieu of a treatment that works. By replacing a statin when you need one with a supplement, you are actually causing harm to that individual. This information is really important for consumers, for patients and for providers.

Amit Khera, MD, MSc, FACC, FAHA, FASPC
Professor of Medicine, Director of Preventive Cardiology
Dallas Heart Ball Chair in Hypertension and Heart Disease
UT Southwestern Medical Center
Immediate Past President, American Society of Preventive Cardiology
Disclosures: Khera reports no relevant financial disclosures.