Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, November 30, 2025

The requirements, the relationships, and the rules: experiences and perceptions of how time is spent supporting recovery on a stroke rehabilitation unit for stroke survivors with aphasia

Daily rehabilitation is appallingly little.

Since only 13% of time is spent in stroke rehab (6 posts), we need to know EXACTLY how much rehab we should be doing on a daily basis. There should be zero downtime, no active rehab; then action observation, mirror therapy, lucid dreaming, cognitive training.

 The requirements, the relationships, and the rules: experiences and perceptions of how time is spent supporting recovery on a stroke rehabilitation unit for stroke survivors with aphasia


Received 04 Jun 2025Accepted 16 Nov 2025Published online: 23 Nov 2025

Effectiveness Of Arm Ability Training With Biofeedback Techniques To Improve Neuroplasticity, Dexterity And Quality Of Life Among Subacute Stroke Survivors

 For those like me with dead brain this wouldn't help at all. Where are my EXACT DEAD BRAIN REHAB PROTOCOLS?

Effectiveness Of Arm Ability Training With Biofeedback Techniques To Improve Neuroplasticity, Dexterity And Quality Of Life Among Subacute Stroke Survivors

  • Mythili D, Narayanasamy K, Kalpana S, Balchandar V, Kotteeswaran K

DOI: 

https://doi.org/10.70082/93m0zp76

Keywords: 

mS-NHPT, FMA-UE, SS-QOL-12, and WMFT

Abstract

OBJECTIVES: One of the main causes of physical disability is stroke, and 80% of stroke survivors suffer upper extremity dysfunction characterized by reduced muscle strength and functional limitation in muscle control and life quality. Arm ability training with biofeedback techniques is reported to enhance the functional recovery of the upper limb by improving the dexterity of the upper limb and life quality.

METHODS: An experimental study to find out the effects of Arm Ability Training with Biofeedback techniques on upper limb dexterity, functional ability, and quality of life in sub-acute stroke survivors. Sixty participants were chosen and randomly allocated to two groups. Group A received Arm ability training with biofeedback techniques, and Group B received conventional therapy for 60 minutes, 5 days/week for 3-4 weeks. The outcome measures were Modified standardized nine-hole peg test (mS-NHPT), Fugl-Meyer Assessment Upper Extremity, 12-item stroke-specific quality of life scale, and Wolf Motor Function Test.

RESULTS: The mean completion time for the m-S NHPT decreased (from 113.78 ± 3.14 to 88.36 ± 2.49), and the FMA-UL increased (from 79.08 ± 2.54 to 90.52 ± 2.92). SS-QOL-12 (19.76 ± 0.99 to 40.12 ± 1.24), WMFT (Functional Ability) (from 46.76 ± 1.47 to 56.92 ± 2.03), and the time score improved (from 478.64 ± 2.9 to 435.16 ± 2.22). The variables indicates a statistical significance (p < 0.05).

CONCLUSION: The above result statistically shows significant improvements in dexterity, functional ability, and life quality of sub-acute stroke subjects.

Timosaponin B-II attenuates cerebral ischemia injury by enhancing Parkin-mediated mitophagy

 

Sounds important for our recovery. Do you really think your incompetent? doctor and hospital will ensure human testing gets done? Competent entities would do that!

Timosaponin B-II attenuates cerebral ischemia injury by enhancing Parkin-mediated mitophagy


https://doi.org/10.1016/j.phymed.2025.157580Get rights and content

Abstract

Background

Ischemic stroke (IS) is linked to dysregulated mitophagy. Timosaponin B-II (TBII), a complex furostan steroid saponin extracted from Anemarrhena asphodeloides Bunge, has been demonstrated to play a crucial role in regulating autophagy. However, whether TBII exerts therapeutic effects in cerebral ischemia through the regulation of autophagy, particularly Parkin-dependent pathways remained unexplored.

Purpose

The present study investigated whether TBII can alleviate cerebral ischemic injury by enhancing Parkin-dependent mitophagy.

Methods

We evaluated TBII’s effects on cerebral ischemic injury using permanent middle cerebral artery occlusion (pMCAO) in mice and oxygen-glucose deprivation (OGD)-treated neurons. Mitophagy and mitochondrial function were assessed by Western blot, transmission electron microscopy (TEM), and immunofluorescence techniques. Parkin knockdown (shPrkn lentivirus) and the mitophagy inhibitor Mdivi-1 were employed to validate TBII’ mechanisms.

Results

Intragastrical (i.g.) administration of TBII (10, 20, 40 mg/kg) for 7 days significantly reduced cerebral infarction volume, brain water content, and neurological deficits in pMCAO mice, while attenuating neuronal death in vivo and in vitro. Molecular docking, cellular thermal shift assays (CETSA), drug affinity responsive target stability (DARTS), and molecular dynamics simulations confirmed that TBII specifically binds and stabilizes to Parkin, suggesting its potential to enhance mitophagy. TBII mitigated the impairment of mitophagy by upregulating Parkin and p-Parkin (Ser65), promoting the ubiquitination of mitochondria, the degradation of autophagy substrate SQSTM1 and damaged mitochondria after IS. TBII also preserved mitochondrial membrane potential (MMP), suppressed oxidative stress, and restored mitochondrial function and ultrastructure. These benefits were reversed by the mitophagy inhibitor Mdivi-1 and Parkin knockdown.

Conclusion

The present study demonstrates that TBII reduces oxidative stress, preserves mitochondrial function, and ultimately attenuates ischemic brain injure by enhancing Parkin-dependent mitophagy. Our study provides the first evidence supporting TBII as a promising therapeutic agent for IS.

Regaining movement and independence following a stroke: Is physical rehabilitation effective?

 Effective to stroke survivors would be 100% recovery; so at 10% full recovery I'd say it is almost completely ineffective! Would you hire anyone for anything if they said they'd only be able to complete 10% of your requirements?

Regaining movement and independence following a stroke: Is physical rehabilitation effective?

The Bottom Line

  • Worldwide, about 1 in 4 people will experience a stroke in their lifetime.
  • Stroke is the leading cause of disability across the globe.
  • In adults who have had a stroke, physical rehabilitation may(NOT WILL!) have the potential to enhance leg movement, balance, and walking speed, as well as the ability to perform daily activities independently.
  • People who have had a stroke should develop a tailored rehabilitation plan with their healthcare team.

Do you know what BE FAST represents? From doctors to commercials, we’ve been exposed to this acronym for years. BE FAST stands for balance, eyes, face, arms, speech, and time. This popular public awareness campaign teaches the signs of stroke and when to seek help. In more detail, these signs include loss of balance, vision changes, face drooping, weakness in the arms and legs, and trouble speaking, and indicate it’s time to call 911 (1).


Globally, it's estimated that 1 in 4 people are at risk of having a stroke at one point in their life (2). So, it’s easy to understand why enormous effort is placed on stroke education. In fact, in countries like Canada, around 80% of people now survive strokes, partly because the signs are recognized early (3). Unfortunately, about 66% of survivors have trouble moving or controlling certain parts of their body—like their arms or legs—right after their stroke, with some impairments continuing in the longer term or even permanently (4). This isn’t surprising when we consider that stroke is the top cause of disability across the globe (2).


For people who survive a stroke, these impairments can impact their ability to complete essential daily activities on their own—like showering, getting dressed, and feeding oneself. Physical rehabilitation, generally delivered by a physiotherapist, aims to help survivors recover movement and function, so they can regain independence. But is it effective? Let’s look at a recent systematic review for answers (4).


What the research tells us

The review found that in adults who have had a stroke, physical rehabilitation may(NOT WILL!) provide long-term improvements in leg movement and the ability to perform essential daily activities independently. These benefits are seen when comparing physical rehabilitation to no physical rehabilitation. Potential shorter-term enhancements in balance and walking speed may(NOT WILL!) also be possible.


The good news doesn’t end there! Seemingly, going above and beyond the usual amount of physical rehabilitation may provide even greater benefits for all the outcomes noted above. However, we’re uncertain whether the benefits of extra physical rehabilitation last long term.


When we know something is potentially effective, we want to learn what variation of it will help us reap the most rewards. In other words, what type of physical rehabilitation is optimal. Here, we see that physical rehabilitation focused on regaining a specific movement by allowing people to practice through real-life activities may be most beneficial for some outcomes.


Overall, these findings are generally based on low certainty evidence, meaning future research may show different results for some outcomes (4).


In the meantime, it’s important that people who have had a stroke, and their caregivers, discuss rehabilitation options with their healthcare team and develop a tailored rehabilitation plan that addresses their wants, needs, and concerns.   

Corticomuscular coupling study for post-stroke rehabilitation: a scoping review

 Maybe this will help explain it, since I have no clue. Nothing here even suggests that this will get survivors recovered; so, what the fuck was it done for?

The latest here:

Corticomuscular coupling study for post-stroke rehabilitation: a scoping review


Abstract

The challenge of post-stroke rehabilitation lies in the difficulty of quantifying the dynamic process of neural remodeling using traditional assessment methods. Corticomuscular coupling (CMC), as an emerging neurophysiological index, offers a novel perspective for quantifying this dynamic process of neural remodeling following a stroke and optimizing rehabilitation interventions. This paper systematically reviews the research advancements in CMC within stroke rehabilitation through a scoping review, focusing on four primary areas: mechanisms, analytical methods, experimental paradigms, and interventions. Studies indicate that CMC can assess('Assessments' DO NOTHING towards recovery; you need EXACT REHAB PROTOCOLS! And this provided none of that, so useless!) the neural mechanisms underlying motor dysfunction and guide personalized rehabilitation strategies by analyzing the dynamic information transfer between the brain and muscles. However, current studies encounter challenges such as technical calibration difficulties, insufficient sample sizes, and the heterogeneity of experimental paradigms. Moving forward, it is essential to promote large-sample multicenter studies, standardize the analytical processes, and explore the synergistic application of CMC with brain-computer interfaces and other technologies to facilitate the paradigm shift from experience-driven to data-driven stroke rehabilitation.

Neural Ultrasound Boosts Learning in 60 Seconds

 Would this help stroke recovery? Or doesn't your incompetent? stroke doctor even follow any research at all? My definition of competence is following AND applying all research that helps stroke recovery! Is your doctor's definition just following what was learned in medical school? So, NOTHING NEW AT ALL?

Neural Ultrasound Boosts Learning in 60 Seconds

Summary: Researchers have successfully altered human reward learning using non-invasive transcranial ultrasound stimulation directed at a deep brain structure linked to motivation. After brief stimulation, participants learned faster from positive feedback and repeated rewarding choices more consistently.

The effects mirrored key aspects of surgical deep brain stimulation but without implants or incisions. The findings suggest ultrasound could become a safer, personalized tool for reshaping faulty reward circuits in mental health disorders.

Key Facts

  • Deep Brain Targeting: Ultrasound successfully modulated the nucleus accumbens without surgery.
  • Faster Reward Learning: Participants showed increased sensitivity to positive outcomes after stimulation.
  • Therapeutic Potential: The technique may one day aid treatment for addiction, depression, and eating disorders.

Source: University of Plymouth

The nucleus accumbens is a tiny element of the human brain triggered when we experience something enjoyable, and used to help us learn behaviours that lead to rewards.

A new study has shown for the first time that its influence on human behaviour can be altered using transcranial ultrasound stimulation (TUS).

Applying the technique for just over a minute at a time, researchers were able to influence how people learned the links between certain cues and rewards.

The result was that they were more likely to repeat a choice that had previously paid off, their learning rates following positive outcomes increased and they were more likely to make positive choices more quickly.

Up to this point, such outcomes have only been achieved through surgical procedures such as deep brain stimulation (DBS), which involves electrodes being directly attached to areas within a person’s brain.

However, those involved in the current study say their findings could signal that TUS has the potential to be used as an equally beneficial – and non-invasive – alternative to help those impacted by neurological or psychiatric disorders including addictions, depression and eating disorders.

The study is published in the journal Nature Communications and was led by researchers from the University of Plymouth. It also involved the University of Oxford, John Radcliffe Hospital, University Hospitals Plymouth NHS Trust, Brown University, and the VA Providence Healthcare System.

Professor Elsa Fouragnan, Director of the Centre for Therapeutic Ultrasound and the Brain Research and Imaging Centre (BRIC) at the University of Plymouth, led the research.

She said: “For decades, the nucleus accumbens has sat at the centre of theories of motivation and reinforcement learning. It is the hub where dopamine signals and limbic inputs converge to shape how strongly rewards pull our choices.

“We were able to pinpoint a clear link between a specific learning trait, tied to impulsivity, and a structure that until now could not be reached without surgery. The fact that we can now modulate this area non-invasively, and in a personalised manner, opens extraordinary possibilities for clinical translation.”

The study forms part of ongoing and pioneering research taking place at the University of Plymouth into the benefits of TUS for conditions including anxiety and depression, addiction and other neurological or psychiatric disorders.

In this project, the researchers recruited 26 healthy participants who visited the BRIC facility four times – once to plan their TUS intervention, followed by three sessions where TUS was applied to different parts of their brain.

Roughly 10 minutes after the ultrasound intervention, participants were placed in the scanner to perform a series of tasks over the space of an hour while the research team monitored changes in their behaviour and brain activity.

The participants’ performance in the tasks was also cross-checked against that of patients with bilateral deep brain stimulation electrodes targeted to the nucleus accumbens as part of therapies for treatment-resistant anorexia nervosa.

The results showed that while DBS often normalises reward-seeking behaviour, TUS had an opposite and excitatory effect – however, both result in people’s learning and reward sensitivity being altered.

Professor Fouragnan added: “This study is the most significant I have had the privilege to lead so far. We uncovered a clear link between a specific cognitive process and a deep-brain structure that, until now, was beyond reach without surgery. It marks a turning point for neurotechnology, showing that a non-invasive ultrasound approach can influence behaviour and may one day help restore mental balance.”

Key Questions Answered:

Q: What part of the brain did scientists influence with ultrasound?

A: A deep reward center called the nucleus accumbens that guides motivation and learning.

Q: What changed after stimulation?

A: People learned faster from positive outcomes and repeated rewarding choices more often.

Q: How is this different from past methods?

A: Similar effects previously required invasive brain surgery.

Editorial Notes:

  • This article was edited by a Neuroscience News editor.
  • Journal paper reviewed in full.
  • Additional context added by our staff.

About this neurotech and learning research news

Author: Alan Williams
Source: University of Plymouth
Contact: Alan Williams – University of Plymouth
Image: The image is credited to Neuroscience News