Deans' stroke musings: Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, November 5, 2023

Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke

Well shit, we've known of the blood brain barrier disruption post stroke for a long time. Why did you do this research?

Blood-Brain Barrier Integrity Suffers Days After Ischemic Stroke Leading To Serious Complications May 2013

The latest unnecessary work here:

Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke

Cell & Bioscience volume 13, Article number: 196 (2023) Cite this article

57 Accesses
Metrics details

Abstract

The blood-brain barrier (BBB) serves as a defensive line protecting the central nervous system, while also maintaining micro-environment homeostasis and inhibiting harmful materials from the peripheral blood. However, the BBB’s unique physiological functions and properties make drug delivery challenging for patients with central nervous system diseases. In this article, we briefly describe the cell structure basis and mechanism of action of the BBB, as well as related functional proteins involved. Additionally, we discuss the various mechanisms of BBB damage following the onset of an ischemic stroke, and lastly, we mention several therapeutic strategies accounting for impairment mechanisms. We hope to provide innovative ideas for drug delivery research via the BBB.

Introduction

Paul Ehrlich [1] made the initial discovery that the dyestuff, when injected into the blood vessels, did not color brain parenchyma. Later, his student Edwin Goldmann [2] made additional observations that showed that the same dyestuff would stain brain tissue if injected into the cerebrospinal fluid. This led to the development of the vague concept of biological barriers between the blood and the brain parenchyma [3]. After conducting extensive research, Dr. Lena Stern presented the term “Barrière hématoencéphalique” to the faculty of Medicine in Geneva [4]. Furthermore, she has published a conceptual article on the topic of the BBB. Following the concrete conceptualization of the BBB, which was developed by Paul Ehrlich, Edwin Goldmann, and Lena Stern, extensive and ongoing studies have been conducted on its morphology, molecular composition, and physiological properties [5]. The BBB maintains the steady-state of the neural system and is therefore considered to be an important structure. Numerous studies have investigated the function of the BBB. Ischemic stroke is a common cause of death worldwide. With the aging of the population, the global burden of stroke is expected to increase [6]. When ischemic stroke occurs, the BBB can be disrupted, resulting in a number of impairments that can worsen the disease’s impact. Currently, maintaining the integrity of the BBB is regarded as an effective treatment strategy for stroke [7].