Deans' stroke musings: Attention-deficit/hyperactivity disorder and ischemic stroke: A Mendelian randomization study

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, July 10, 2022

Attention-deficit/hyperactivity disorder and ischemic stroke: A Mendelian randomization study

Until your stroke researchers actually do their job of preventing this risk, you'll just not have to have ADHD.

Attention-deficit/hyperactivity disorder and ischemic stroke: A Mendelian randomization study

Show all authors

Runming Du

, Yi Zhou, Chong You, ...

First Published July 6, 2022 Research Article Find in PubMed

Abstract

Background:

Observational studies have found an association between attention-deficit/hyperactivity disorder (ADHD) and ischemic stroke.

Aims:

The purpose of this study was to investigate whether genetic liability to ADHD has a causal effect on ischemic stroke and its subtypes.

Methods:

In this two-sample Mendelian randomization (MR) study, genetic variants (nine single-nucleotide polymorphisms; P < 5 × 10^-8) using as instrumental variables for the analysis was obtained from a genome-wide association study of ADHD with 19,099 cases and 34,194 controls. The outcome datasets for stroke and its subtypes were obtained from the MEGASTROKE consortium, with 40,585 cases and 406,111 controls. MR inverse variance-weighted method was conducted to investigate the effect of genetic liability to ADHD on ischemic stroke and its subtypes. Sensitivity analyses (median-based methods, MR-Egger, MR-robust adjusted profile scores, MR-pleiotropy residual sum and outlier) were also utilized to assess horizontal pleiotropy and remove outliers. Multivariable MR (MVMR) analyses were conducted to explore potential mediators.

Results:

Genetically determined ADHD (per 1 SD) was significantly associated with a higher risk of any ischemic stroke (AIS) (odds ratio (OR) = 1.15, 95% confidence interval (CI) = 1.05–1.25, P = 0.002) and large-artery atherosclerotic stroke (LAS) (OR = 1.40, 95% CI = 1.10–1.76, P = 0.005). The significant association was also found in sensitivity analyses and MVMR analyses.

Conclusions:

Genetic liability to ADHD was significantly associated with an increased risk of AIS, especially LAS. The association between ADHD and LAS was independent of age of smoking initiation but mediated by coronary artery disease.

Keywords

Attention-deficit/hyperactivity disorder, ischemic stroke, Mendelian randomization