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Innovative Approaches and Therapies to Enhance Neuroplasticity and Promote Recovery in Patients with Neurological Disorders: A Narrative Review
Published: July 15, 2023
DOI: 10.7759/cureus.41914
Cite this article as: Kumar J, Patel T, Sugandh F, et al. (July 15, 2023) Innovative Approaches and Therapies to Enhance Neuroplasticity and Promote Recovery in Patients with Neurological Disorders: A Narrative Review. Cureus 15(7): e41914. doi:10.7759/cureus.41914
Abstract
Brain rehabilitation and recovery for people with neurological disorders, such as stroke, traumatic brain injury (TBI), and neurodegenerative diseases, depend mainly on neuroplasticity, the brain's capacity to restructure and adapt. This literature review aims to look into cutting-edge methods and treatments that support neuroplasticity and recovery in these groups. A thorough search of electronic databases revealed a wide range of research and papers investigating several neuroplasticity-targeting methods, such as cognitive training, physical activity, non-invasive brain stimulation, and pharmaceutical interventions. The results indicate that these therapies can control neuroplasticity and improve motor, mental, and sensory function. In addition, cutting-edge approaches, such as virtual reality (VR) and brain-computer interfaces (BCIs), promise to increase neuroplasticity and foster rehabilitation. However, many issues and restrictions still need to be resolved, including the demand for individualized treatments and the absence of defined standards. In conclusion, this review emphasizes the significance of neuroplasticity in brain rehabilitation. It identifies novel strategies and treatments that promise to enhance recovery in patients with neurological illnesses. Future studies should concentrate on improving these therapies and developing evidence-based standards to direct clinical practice and enhance outcomes for this vulnerable population.
Introduction & Background
In the fields of neuroscience and rehabilitation, there has been a significant increase in interest regarding neuroplasticity, which refers to the brain's extraordinary ability to undergo changes and reorganization. It speaks to the ability of the brain to adapt its form and function in response to outside stimuli, knowledge, and experience. Neuroplasticity is crucial to brain rehabilitation to recover and regain function following neurological insults, such as stroke, traumatic brain injury (TBI), or neurodegenerative illnesses [1]. This in-depth narrative review explores cutting-edge methods and treatments that support neuroplasticity and encourage recovery in people with these neurological illnesses.
A key factor underlying brain adaptability and resilience is neuroplasticity. The brain's ability to alter was once thought to be restricted to crucial stages of development. However, recent studies have revealed that neuroplasticity lasts throughout a person's life [2]. This newfound knowledge has completely changed how brain rehabilitation is practiced by opening new doors for treatment and recovery. It is impossible to overestimate the significance of neuroplasticity in brain recovery. Following a brain injury or illness, it is the foundation for functional recovery and remodeling [2,3]. By rerouting neuronal pathways, creating new connections, and enlisting alternate regions to carry out disrupted duties, neuroplasticity enables the brain to make up for damaged areas. Individuals with neurological diseases may experience amazing healing if neuroplasticity is harnessed and enhanced through focused therapies.
Stroke is a neurological condition that can be treated using neuroplasticity-based methods. Blood flow to the brain is disrupted during a stroke, which causes damage to brain tissues, and is one of the leading causes of disability globally. Motor, linguistic, cognitive, and sensory processing deficits are common in stroke survivors [4]. By promoting healing and functional restoration, neuroplasticity is essential to stroke rehabilitation. Neuroplasticity can be tapped into through a variety of treatments, including virtual reality (VR), transcranial magnetic stimulation (TMS), constraint-induced movement therapy (CIMT), and pharmaceutical interventions. Another neurological illness for which neuroplasticity-based treatment strategies have shown promise is TBI. TBI happens when an outside force damages the brain, which results in cognitive, behavioral, and physical problems; the capacity of the brain to heal and remodel itself after TBI is supported by neuroplasticity [4,5]. To activate neuroplastic changes and advance rehabilitation in people with TBI, cognitive training programs and neuromodulation methods, including repetitive TMS (rTMS) and transcranial electrical stimulation (TES), and pharmaceutical therapies are used. These treatments focus on particular brain circuits, encourage synaptic plasticity, and improve cognitive abilities [5].
Neuroplasticity-based treatments are also advantageous for neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. These conditions cause the progressive degradation of brain tissues, which worsens cognitive function, impairs movement, and causes other distressing symptoms [5]. Emerging research reveals that the brain retains some degree of plasticity even in pathology, even though neurodegenerative disorders are frequently characterized by neuroplasticity impairment. Modulating neuroplasticity, halting disease development, and easing symptoms have all been proven possible with pharmaceutical therapies, cognitive training, physical exercise, and non-invasive brain stimulation techniques (e.g., TMS and tDCS) [5,6].
Finally, neuroplasticity is a crucial component of brain rehabilitation in people with neurological conditions, such as stroke, TBI, and neurodegenerative illnesses. Understanding the mechanisms and principles of neuroplasticity lays the groundwork for creating novel strategies and treatments to speed healing and encourage functional recovery [6]. Neuroplasticity-based therapies give people with neurological illnesses hope and promise by taking advantage of the brain's extraordinary capacity to rearrange itself. The mechanics, effectiveness, and potential future directions in neuroplasticity and brain rehabilitation will all be examined in this narrative review, which will delve deeply into these cutting-edge methods and treatments [7].
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