Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin

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• irisin (8 posts to October 2013)

 

Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin

• Hao Wu
• , 
• Qian Zhang
• , 
• Pu Xu
• , 
• Jiepeng Chen
• , 
• Lili Duan
• , 
• Feng Xu*
• , and 
• Fengjiao Zhang*
• 
  

Cite this: J. Agric. Food Chem. 2023, XXXX, XXX, XXX-XXX

Publication Date:July 19, 2023

https://doi.org/10.1021/acs.jafc.2c08718

© 2023 American Chemical Society

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Supporting Info (1)»Supporting Information

Journal of Agricultural and Food Chemistry

Abstract

The therapeutic potential of treatments for post-stroke cognitive impairment (PSCI) is severely limited by the autonomic regeneration capacity of the adult brain. Nattokinase (NK), a serine protease from the traditional food natto, has many beneficial effects on the cardiovascular system by modulating the blood system. While the role of blood factors in neurogenesis and cognition is well-established, it remains unclear whether NK can serve as an anti-PSCI agent through these factors. Our study demonstrates that NK protects against acute ischemic stroke and impressively promotes neurogenesis in rat models by increasing peripheral blood irisin, leading to improved cognitive functions. Our findings demonstrate NK to be a promising candidate for treating PSCI, and we also highlight irisin as a novel target of NK, suggesting its potential role in the peripheral blood-to-brain axis.

KEYWORDS:

• post-stroke cognitive impairment
• nattokinase
• irisin
• hippocampal neurogenesis

Supporting Information

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The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jafc.2c08718.

• Passive avoidance test and the Y-maze test (Figure S1), neurogenesis in the CA1 area of the hippocampus (Figure S2), hippocampal neurogenesis in the non-occlusion lateral brain (Figure S3), hippocampal neurogenesis in 14 days after IS (Figure S4), effects of NK on the level of specific blood factors (Figure S5), and effect of NK on the expression of FDNC5 in rat tissues with or without FNDC5 knockdown (Figure S6) (PDF)