Deans' stroke musings: The association of high-sensitivity C-reactive protein-triglyceride glucose index with functional outcome in elderly patients with acute ischemic stroke undergoing intravenous thrombolysis

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, September 21, 2026

The association of high-sensitivity C-reactive protein-triglyceride glucose index with functional outcome in elderly patients with acute ischemic stroke undergoing intravenous thrombolysis

'Associations' don't get you recovered, or are you too fucking stupid to see that? What prevents post stroke cognitive impairment is the needed research, not this crapola!

The association of high-sensitivity C-reactive protein-triglyceride glucose index with functional outcome in elderly patients with acute ischemic stroke undergoing intravenous thrombolysis

Pengyu Gong 1†
Gang Chen 2†
Shuaiyu Chen 3
Y
Yaya Fei 1
Y
Yuye Jiang 1
Y
Yiyang Zhang 1
J
Jiajie Lu 1
J
Jianhua Song 4
Y
Yuechun Wang 1*

1. Department of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China
2. Department of Neurology, Haimen Hospital Affiliated to Nantong University, Nantong, Jiangsu, China

Abstract

Background and purpose:

High-sensitivity C-reactive protein-triglyceride-glucose index (CTI) is an innovative biomarker of insulin resistance and inflammation. The objective of this study was to explore the association of high-sensitivity CTI with functional outcome in elderly patients with acute ischemic stroke (AIS) undergoing intravenous thrombolysis (IVT).

Methods:

Elderly AIS patients treated with IVT were enrolled in three centers. Unfavorable functional outcome was defined as Modified Rankin Scale score ranging from 3–6. Logistic regression models were used to calculate the odds ratio (OR) and 95% confidence interval (95% CI) for the association between high-sensitivity CTI and 3-month functional outcome. Restricted cubic splines (RCS) were performed to explore the shape of this association. Receiver operating characteristic curve was applied to evaluate the discriminatory capacity of high-sensitivity CTI. Furthermore, subgroup and sensitivity analyses were performed to examine the consistency of the observed association.

Results:

A total of 708 elderly patients were enrolled, among whom 231 (32.6%) developed unfavorable functional outcome at 3 month follow up. In Model 3, higher continuous high sensitivity CTI levels were independently associated with 3 month unfavorable functional outcome among elderly AIS patients receiving IVT (OR = 1.64; 95% CI, 1.28–2.11). Taking the first quartile of high sensitivity CTI as the reference group, patients in the fourth quartile exhibited the highest risk of unfavorable functional outcome in Model 3 (OR = 2.62, 95% CI, 1.48–4.64). RCS revealed a significant overall association between high sensitivity CTI and unfavorable functional outcome, with no statistically significant nonlinear component (P for overall < 0.001; P for nonlinearity = 0.743). Subgroup and sensitivity analyses demonstrated consistent directions of associations.

Conclusion:

High-sensitivity CTI was independently associated with functional outcome at 3 months in elderly AIS patients treated with IVT.