Deans' stroke musings: Association of serum uric acid with early post-stroke cognitive impairment after acute minor ischemic stroke and transient ischemic attack

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, September 21, 2026

Association of serum uric acid with early post-stroke cognitive impairment after acute minor ischemic stroke and transient ischemic attack

'Associations' don't get you recovered, or are you too fucking stupid to see that? What prevents post stroke cognitive impairment is the needed research, not this crapola!

Association of serum uric acid with early post-stroke cognitive impairment after acute minor ischemic stroke and transient ischemic attack

Scientific Reports (2026) Cite this article

Abstract

Serum uric acid (SUA) is associated with cognitive impairment, but relevant studies are controversial, and studies on SUA and cognitive impairment after acute minor ischemic stroke and transient ischemic attack (TIA) are scarce. This exploratory study included 543 patients with mild ischemic stroke and TIA who were admitted to the First Hospital of Jilin University from April 2019 to March 2022. Demographic, imaging, hematological data and comprehensive cognitive scale assessment were collected. Early Post-Stroke cognitive impairment was defined as a Montreal Cognitive Assessment score < 22 points, assessed at 7–10 days after acute minor ischemic stroke or TIA. The association between SUA and early PSCI was assessed using multivariable logistic regression, adjusting for both clinically relevant variables and those significant in univariate analysis. Sensitivity analysis was performed by excluding the 5 participants with the highest serum SUA values. A restricted cubic spline was employed to evaluate potential nonlinear relationships, followed by segmented regression and stratified analysis by age (< 65 years) and sex. SUA showed a nonlinear association with early PSCI, with the lowest estimated risk observed at approximately 409 µmol/L. For every 1 µmol/L increase between 256.87 and 408.99 µmol/L, the risk of early PSCI decreased by 0.7% (OR 0.993, 95% CI 0.989–0.997, P < 0.001). In cognitive domain analyses, SUA also showed nonlinear associations with memory and executive function. Similar findings were observed after exclusion of extreme high SUA values. The association between SUA and early PSCI was generally consistent across sex and age subgroups. SUA showed a nonlinear association with early cognitive impairment after acute minor ischemic stroke and TIA. These findings are hypothesis-generating and require confirmation in larger longitudinal studies.