Deans' stroke musings: Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, April 24, 2024

Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis

Ask you competent? doctor if you need myelin repair post stroke, and don't accept not knowing as an answer. YOUR FUCKING DOCTOR IS SUPPOSED TO BE COMPETENT! Only over a decade for your doctor to become competent in myelin!

In here is both myelin repair topics and whether stroke causes myelin damage.

myelin (73 posts to April 2011)

Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis

Published:April 22, 2024DOI:https://doi.org/10.1016/j.neuron.2024.03.026

Highlights

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GH treatment promotes myelin repair and functional recovery after hypoxia
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GHR is selectively expressed by a subpopulation of pericytes
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GHR-positive pericyte-tip cells lead blood vessel bridging and branching
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GHR-positive pericytes modulate angiogenesis and govern myelination indirectly

Summary

White matter injury (WMI) causes oligodendrocyte precursor cell (OPC) differentiation arrest and functional deficits, with no effective therapies to date. Here, we report increased expression of growth hormone (GH) in the hypoxic neonatal mouse brain, a model of WMI. GH treatment during or post hypoxic exposure rescues hypoxia-induced hypomyelination and promotes functional recovery in adolescent mice. Single-cell sequencing reveals that Ghr mRNA expression is highly enriched in vascular cells. Cell-lineage labeling and tracing identify the GHR-expressing vascular cells as a subpopulation of pericytes. These cells display tip-cell-like morphology with kinetic polarized filopodia revealed by two-photon live imaging and seemingly direct blood vessel branching and bridging. Gain-of-function and loss-of-function experiments indicate that GHR signaling in pericytes is sufficient to modulate angiogenesis in neonatal brains, which enhances OPC differentiation and myelination indirectly. These findings demonstrate that targeting GHR and/or downstream effectors may represent a promising therapeutic strategy for WMI.