Deans' stroke musings: Cognitive reserve and risk of poststroke cognitive impairment in acute ischaemic stroke: post hoc analysis of CATIS-2

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there. Did your doctor somehow miss the recovery protocol that Pedro Bach-y-Rita used to recover fully back in 1958 with only a partial brain?

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, October 26, 2026

Cognitive reserve and risk of poststroke cognitive impairment in acute ischaemic stroke: post hoc analysis of CATIS-2

You incompetently didn't give us EXACT PROTOCOLS to rebuild cognitive reserve post stroke! What the fuck good did this research do?

Cognitive reserve and risk of poststroke cognitive impairment in acute ischaemic stroke: post hoc analysis of CATIS-2

Abstract

Background The impact of cognitive reserve (CR) on poststroke cognitive impairment (PSCI) remains unclear. This study aimed to investigate the association between CR proxy scores derived from an education-residence proxy index and PSCI.

Methods We conducted a post hoc analysis of the China Acute Ischemic Stroke Hypotension Trial II cohort including acute ischaemic stroke (AIS) patients without prior dementia who completed 3-month cognitive assessment. A CR proxy score was constructed using principal component analysis based on education and residential location. PSCI was defined as Montreal Cognitive Assessment <25. Logistic regression and restricted cubic spline (RCS) analyses were used to examine associations between CR and PSCI.

Results PSCI occurred in 1019 of 1682 patients (60.6%). Higher CR proxy scores were associated with lower odds of PSCI (OR=0.88; 95% CI 0.81 to 0.96; p=0.01), with similar findings in the fully adjusted model (OR=0.89; 95% CI 0.81 to 0.98; p=0.02). RCS analyses showed a linear inverse association between CR proxy scores and PSCI (P overall=0.001; P non-linear=0.35). Component analyses suggested that educational attainment was the predominant contributor to the observed association.

Conclusions The education-residence-based CR proxy score was associated with lower odds of PSCI after AIS. The observed associations require cautious interpretation and further validation using comprehensive CR measures.

Trial registration number NCT03479554.