Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, October 22, 2026

Neuroplasticity Biomarkers and Neurotransmitter Modulation in Post-Ischemic Stroke Rehabilitation: A Narrative Review

You know nothing about how to make neuroplasticity repeatable on demand, so a useless word salad!

When your incompetent? doctor/researcher uses this word ask them to EXPLAIN EXACTLY what needs to happen for a neuron to drop a current task and take on a neighbors!

NO explanation; PURE FUCKING INCOMPETENCE! Not knowing that makes neuroplasticity non repeatable on demand!

Neuroplasticity Biomarkers and Neurotransmitter Modulation in Post-Ischemic Stroke Rehabilitation: A Narrative Review

-Ischemic Stroke Rehabilitation: A Narrative Review

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Department of Neurology, Dr. K. Jonscher Muncipal Medical Centre in Lodz, Milionowa 14, 93-113 Łódź, Poland

Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Łódź, Poland

Department of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, 93-113 Łódź, Poland

Authors to whom correspondence should be addressed.

J. Clin. Med.2026, 15(20), 8091;https://doi.org/10.3390/jcm15208091

This article belongs to the Special Issue Cerebrovascular Disease: Symptoms, Diagnosis and Current Treatment—Second Edition

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Abstract

Background/Objectives:

Recovery after stroke is a complex process involving structural and functional reorganization of the nervous system. Neuroplasticity plays a key role in functional recovery, while biomarkers and neurotransmitter systems may reflect or modulate the biological processes underlying rehabilitation and adaptation after stroke. The aim of this review was to summarize the current evidence regarding biomarkers of neuroplasticity and neurotransmitter modulation in post-stroke rehabilitation, with a particular focus on their potential importance for functional recovery and rehabilitation outcomes.

Methods:

This narrative review synthesized evidence identified through searches of PubMed/MEDLINE, Scopus, and Web of Science, supplemented by reference-list screening. The literature was qualitatively analyzed according to the main themes of the review.

Results:

Current data point to BDNF, VEGF, and MMPs as promising biomarkers associated with post-stroke neuroplasticity and functional recovery. Neurotransmitter modulation, particularly involving GABA, glutamate, dopamine, and serotonin, may influence neuronal excitability, synaptic plasticity, and motor learning after stroke. The combination of biomarker assessment and rehabilitation-based modulation of these pathways may provide a more comprehensive approach to understanding and monitoring post-stroke recovery.

Conclusions:

Current evidence supports the role of neuroplasticity-related biomarkers and neurotransmitter modulation as potential tools for understanding biological responses to post-stroke rehabilitation. However, their clinical relevance and usefulness in guiding individualized rehabilitation require further validation in future clinical studies.