Will your competent? doctor and hospital GUARANTEE THAT FOLLOWUP RESEARCH WILL OCCUR THAT STOPS THIS PROBLEM!
Can't do that? PURE INCOMPETENCE AND A FIREABLE OFFENSE!
MRI Study Links Tightness of High-Convexity Sulci to Higher Risk of Cognitive Decline in Older Adults
Tightness of the high-convexity sulci (THC) on brain MRI was associated with nearly threefold higher odds of cognitive decline over five to seven years of follow-up, according to a new prospective study involving over 2,100 community-dwelling senior citizens.
Emerging brain MRI research suggests that tightness of the high-convexity sulci (THC) is associated with significantly elevated risks for long-term cognitive decline.
For the prospective study, recently published in
The researchers found that 46.3 percent of the cohort had incomplete DESH (defined as one or two of the aforementioned DESH features) and only 1.7 percent of the cohort had complete DESH (all three of the aforementioned features). There were no DESH features on baseline MRI for 51.9 percent of the cohort, according to the study authors.
Here one can see brain MRI scans revealing ventricular enlargement and different features of disproportionately enlarged subarachnoid space hydrocephalus (DESH), including an Evans index > 0.3 (A), a focally enlarged sulci (B), temporal horn enlargement (> 6 mm) (C), a reduced callosal angle (< 90o) (D) and periventricular hyperintensity with correspondence to Fazekas grade 3 (E). (Images courtesy of Radiology.)
However, the presence of THC on baseline MRI was associated with a nearly threefold higher risk for cognitive decline within five to seven years. The researchers noted the elevated risk was evident in the entire cohort as well as those deemed to be cognitively normal in baseline testing.
“These findings suggest that careful assessment of THC may aid early risk stratification. Future studies incorporating longitudinal imaging will be needed to clarify the mechanisms underlying THC and to establish its role in early risk stratification for cognitive decline,” noted lead study author Kana Saito, MD, who is affiliated with the Department of Radiology at the Hirosaki University Graduate School of Medicine in Hirosaki, Japan, and colleagues.
Three Key Takeaways
• Tightness of the high-convexity sulci (THC) on brain MRI may be a useful early warning sign. In this prospective study of 2,133 community-dwelling older adults (median age 69), THC at baseline was linked to a nearly threefold higher risk of cognitive decline over five to seven years. The association held in participants who were cognitively normal at baseline, which suggests the finding could help with risk stratification before symptoms appear.
• THC combined with Sylvian fissure enlargement may be more informative than traditional DESH criteria. People who had both THC and enlarged Sylvian fissures (ESF) were 83 percent more likely to have long-term cognitive decline. The authors suggest this pairing may be a more clinically meaningful marker than the Evans index or complete DESH. Complete DESH was rare in the cohort (1.7 percent), while incomplete DESH was common (46.3 percent). This supports assessing individual DESH features rather than only the full triad.
• The findings are promising but not yet ready for routine use. Cognitive outcomes were based on clinical diagnosis of MCI or dementia rather than standardized neuropsychological testing. The cohort was also limited to older Japanese adults from a single region, which may restrict generalizability. The authors call for longitudinal imaging studies to clarify how THC develops and to confirm its role in early risk stratification.
No comments:
Post a Comment