Deans' stroke musings: Elevated C-reactive protein-to-albumin ratio is associated with early neurological deterioration in acute ischemic stroke: a retrospective cohort study

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there. Did your doctor somehow miss the recovery protocol that Pedro Bach-y-Rita used to recover fully back in 1958 with only a partial brain?

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, October 26, 2026

Elevated C-reactive protein-to-albumin ratio is associated with early neurological deterioration in acute ischemic stroke: a retrospective cohort study

Describing a problem with NO solution is a fireable offense in any business!

Elevated C-reactive protein-to-albumin ratio is associated with early neurological deterioration in acute ischemic stroke: a retrospective cohort study

1. Department of Hematology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China
2. Department of Neurosurgery, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China

Abstract

Background:

Early neurological deterioration (END) is a frequent complication of acute ischemic stroke (AIS) that contributes to poor clinical outcomes. The C-reactive protein-to-albumin ratio (CAR) reflects systemic inflammation relative to albumin levels and may be associated with END. We evaluated the association between log₂-transformed CAR and END in patients with AIS.

Methods:

We retrospectively analyzed 1,766 patients with AIS admitted between September 2016 to September 2022. END was defined as an increase of ≥2 points in the NIHSS motor item or total score within 72 h of admission. Associations between log₂-CAR and END were assessed using a multivariable logistic regression analysis. Generalized additive and two-piecewise regression models were used as exploratory analyses to assess potential non-linearity. ROC curves were used to compare CAR with established biomarkers and the A2DS2 score.

Conclusion:

Higher CAR was independently associated with END in this cohort. CAR’s strongest predictive advantage was observed when compared with the A2DS2 clinical score, whereas superiority over CRP alone was not demonstrated. The possible threshold at a raw CAR of approximately 0.020 is exploratory and requires independent validation.