Thromboinflammation in Brain Ischemia: Recent Updates and Future Perspectives

 Your doctor will need to read this and see if these new updates require changing stroke protocols in use at their hospital.

Thromboinflammation in Brain Ischemia: Recent Updates and Future Perspectives

Simon F. De Meyer

,

Friederike Langhauser

,

Steffen Haupeltshofer

,

Christoph Kleinschnitz

and

Ana I. Casas

Originally published1 Apr 2022https://doi.org/10.1161/STROKEAHA.122.038733Stroke. 2022;0:10.1161/STROKEAHA.122.038733

Abstract

Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal damage following the ischemic event. Hence, we here review the most recent updates on thromboinflammatory-dependent mediators relevant after stroke focusing on recent discoveries on platelet modulation, a potential regulation of the innate and adaptive immune system in thromboinflammation, utterly providing a thorough up-to-date overview of all therapeutic approaches currently undergoing clinical trial.

Footnotes

*C. Kleinschnitz and A.I. Casas contributed equally.

For Sources of Funding and Disclosures, see page xxx.

Correspondence to: Ana I. Casas, PhD, Department of Neurology of University Hospital Essen, Germany. Email anaisabel.casasguijarro@uk-essen.de