Deans' stroke musings: Exosomes: From Non- Invasive Detection to Engineered Targeted Therapy

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, February 15, 2026

Exosomes: From Non- Invasive Detection to Engineered Targeted Therapy

Your competent? doctor should have had exosomes on the follow research list ever since it was found that exosomes are the reason stem cell therapy works. Oh, your doctor doesn't know that? And that doctor is still employed because the board of directors is so fucking incompetent that they know nothing about stroke research and what is needed for recovery!

But why go thru all the trouble of stem cells if exosomes are the reason for the benefits? Which must be why no one seems to be monitoring stem cell survival.

Application of stem cell-derived exosomes in ischemic diseases: opportunity and limitations

The latest here:

Exosomes: From Non- Invasive Detection to Engineered Targeted Therapy

Mingming Sun 1 |

Hang Hu 1 |

Yi Gong 1,2

1 School of Life Sciences, Nanchang University, Nanchang, China |

2 Key Laboratory for Aquatic Germplasm Innovation and Utilization of Jiangxi Province, Nanchang University, Nanchang, China

Correspondence: Yi Gong (gongyi@ncu.edu.cn) Received: 18 November 2025 | Revised: 21 January 2026 | Accepted: 2 February 2026

Keywords: engineering strategies | exosome | non- invasive diagnosis

ABSTRACT

Exosomes are naturally occurring nanovesicles present in a variety of bodily fluids that facilitate the transport of proteins and nucleic acids. Characterized by their low immunogenicity and high biocompatibility, exosomes can efficiently navigate through biological barriers. This review summarizes the applications of exosomes in disease diagnosis and treatment, emphasizing their roles as biomarkers for non- invasive detection, as well as engineered vehicles for drug delivery and vaccine development. Additionally, this review also discusses recent technological advancements in exosome engineering, including genetic modification techniques and chemical modifications aimed at optimizing targeted delivery systems and enhancing immunomodulation strategies. Notably, it highlights the significant potential of exosomes to transform non-invasive diagnostics while promoting the development of sophisticated therapeutic carriers